Results 251 to 260 of about 149,566 (304)

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Senescent Synovial Intimal Fibroblasts Aggravate Osteoarthritis by Regulating Macrophage Polarization and Chondrocyte Phenotype Through ANGPTL4‐α5β1 Axis

Advanced Science, EarlyView.
Senescent synovial intimal fibroblasts (SIF) are identified as key drivers of osteoarthritis. They promote M1 macrophage polarization and cartilage degeneration via the ANGPTL4–α5β1 axis, regulated by transcription factors EGR1 and ATF3. Pharmacological inhibition of this pathway alleviates disease, revealing SIF senescence as a promising therapeutic ...
Muhai Deng, Yunsheng Jiang, Zhiyu Chen, Kaiquan Chen, Na Cao, Yang Huang, Zhengxue Quan, Cheng Chen   +7 more
wiley   +1 more source

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Primate-specific histone variants

Genome, 2021
Canonical histones (H2A, H2B, H3, and H4) are present in all eukaryotes where they package genomic DNA and participate in numerous cellular processes, such as transcription regulation and DNA repair. In addition to the canonical histones, there are many histone variants, which have different amino acid sequences, possess tissue-specific expression ...
Ding, Dongbo, Nguyen, Thi Thuy, Pang, Yu Hin, Ishibashi, Toyotaka   +3 more
openaire   +3 more sources

Histone Variants and Histone Modifications in Neurogenesis

Trends in Cell Biology, 2020
During embryonic brain development, neurogenesis requires the orchestration of gene expression to regulate neural stem cell (NSC) fate specification. Epigenetic regulation with specific emphasis on the modes of histone variants and histone post-translational modifications are involved in interactive gene regulation of central nervous system (CNS ...
Mengtian Zhang, Jinyue Zhao, Yuqing Lv, Wenwen Wang, Chao Feng, Wenzheng Zou, Libo Su, Jianwei Jiao   +7 more
openaire   +2 more sources

Monoclonal Autoantibodies Recognizing Histone Variants

Immunological Investigations, 1988
Balb/c mice were immunized with affinity purified Ro(SS-A) from human origin in order to allow the preparation of monoclonal anti-Ro(SS-A) antibodies. After fusion of mouse myeloma cells (line Sp2/0 A914) with spleen cells from one of these mice, anti-Ro(SS-A) monoclonals were not obtained, but, instead, two IgM producing hybridomas reactive with ...
van Hemert, Formijn J., van Dam, Alje P., Jonk, Luigi J. C., Olivier, H. J., Destrée, J. T., Smeenk, Ruud J. T.   +5 more
openaire   +3 more sources

Nucleosome dynamics and histone variants

Essays in Biochemistry, 2010
In eukaryotes, DNA is organized into chromatin, a dynamic structure that enables DNA to be accessed for processes such as transcription, replication and repair. To form, maintain or alter this organization according to cellular needs, histones, the main protein component of chromatin, are deposited, replaced, exchanged and post-translationally modified.
Dominique, Ray-Gallet, Geneviève, Almouzni   +1 more
openaire   +2 more sources

Histone variants and epigenetic inheritance

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2012
Nucleosome particles, which are composed of core histones and DNA, are the basic unit of eukaryotic chromatin. Histone modifications and histone composition determine the structure and function of the chromatin; this genome packaging, often referred to as "epigenetic information", provides additional information beyond the underlying genomic sequence ...
Gang, Yuan, Bing, Zhu
openaire   +2 more sources

Histone variants meet their match

Nature Reviews Molecular Cell Biology, 2005
A fascinating aspect of how chromatin structure impacts on gene expression and cellular identity is the transmission of information from mother to daughter cells, independently of the primary DNA sequence. This epigenetic information seems to be contained within the covalent modifications of histone polypeptides and the distinctive characteristics of ...
Kavitha, Sarma, Danny, Reinberg
openaire   +2 more sources

Histone variants and lipid metabolism

Biochemical Society Transactions, 2014
Within nucleosomes, canonical histones package the genome, but they can be opportunely replaced with histone variants. The incorporation of histone variants into the nucleosome is a chief cellular strategy to regulate transcription and cellular metabolism.
Borghesan, M., Mazzoccoli, G., Sheedfar, F., Oben, J., Pazienza, V., Vinciguerra, M.   +5 more
openaire   +4 more sources

Histone variants and histone modifications: A structural perspective

Biochemistry and Cell Biology, 2001
In this review, we briefly analyze the current state of knowledge on histone variants and their posttranslational modifications. We place special emphasis on the description of the structural component(s) defining and determining their functional role. The information available indicates that this histone "variability" may operate at different levels:
J, Ausió, D W, Abbott, X, Wang, S C, Moore   +3 more
openaire   +2 more sources