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ASSEMBLY OF VARIANT HISTONES INTO CHROMATIN
Annual Review of Cell and Developmental Biology, 2005Chromatin can be differentiated by the deposition of variant histones at centromeres, active genes, and silent loci. Variant histones are assembled into nucleosomes in a replication-independent manner, in contrast to assembly of bulk chromatin that is coupled to replication.
Steven, Henikoff, Kami, Ahmad
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Nucleosome dynamics and histone variants
Essays in Biochemistry, 2010In eukaryotes, DNA is organized into chromatin, a dynamic structure that enables DNA to be accessed for processes such as transcription, replication and repair. To form, maintain or alter this organization according to cellular needs, histones, the main protein component of chromatin, are deposited, replaced, exchanged and post-translationally modified.
Dominique, Ray-Gallet +1 more
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Histone variants and epigenetic inheritance
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2012Nucleosome particles, which are composed of core histones and DNA, are the basic unit of eukaryotic chromatin. Histone modifications and histone composition determine the structure and function of the chromatin; this genome packaging, often referred to as "epigenetic information", provides additional information beyond the underlying genomic sequence ...
Gang, Yuan, Bing, Zhu
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Histone variants and lipid metabolism
Biochemical Society Transactions, 2014Within nucleosomes, canonical histones package the genome, but they can be opportunely replaced with histone variants. The incorporation of histone variants into the nucleosome is a chief cellular strategy to regulate transcription and cellular metabolism.
Borghesan, M. +5 more
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2018
In eukaryotes, the genome is organized into a complex nucleoprotein structure called chromatin. Despite the simplicity of its monomer, DNA and two copies of four histones, the existence of histone variants opens possibilities of multiple chromatin landscapes and fine-tune regulation of molecular mechanisms for the regulation of gene expression and ...
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In eukaryotes, the genome is organized into a complex nucleoprotein structure called chromatin. Despite the simplicity of its monomer, DNA and two copies of four histones, the existence of histone variants opens possibilities of multiple chromatin landscapes and fine-tune regulation of molecular mechanisms for the regulation of gene expression and ...
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[Histone variants and histone exchange].
Yi chuan = Hereditas, 2009Histones, as the basic components of nucleosome, are essential to chromatin structure and function. To adapt to various states of chromatin, corresponding histone variants are incorporated in nucleosome, and certain modifications also occur on the variants' tails.
Nan, Wu, Jian-Fang, Gui
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Novel histones and histone variant families in prokaryotes
2023Abstract Histones are important chromatin-organizing proteins in eukaryotes and archaea. They form superhelical structures around which DNA is wrapped. Recent studies have shown that some archaea and bacteria contain alternative histones that exhibit different DNA binding properties, in addition to highly divergent ...
Samuel Schwab +8 more
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H 1 histone and histone variants in Trypanosoma cruzi
Experimental Cell Research, 1988Trypanosoma cruzi chromatin is not condensed in chromosomes during mitosis. In previous studies a characteristic H 1 was not found in SDS or in acid-urea-PAGE. Consequently, it was proposed that the particular behavior of T. cruzi chromatin in dividing cells was due to the absence of an H 1 histone. In the present work, histones from this parasite were
G C, Toro, N, Galanti
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Monoclonal Autoantibodies Recognizing Histone Variants
Immunological Investigations, 1988Balb/c mice were immunized with affinity purified Ro(SS-A) from human origin in order to allow the preparation of monoclonal anti-Ro(SS-A) antibodies. After fusion of mouse myeloma cells (line Sp2/0 A914) with spleen cells from one of these mice, anti-Ro(SS-A) monoclonals were not obtained, but, instead, two IgM producing hybridomas reactive with ...
van Hemert, Formijn J. +5 more
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Histone Variants and Transcription Regulation
2012Histones are the protein components of chromatin and are important for its organization and compaction. Although core histones are exclusively expressed during S phase of the cell cycle, there exist variants of canonical histones that are expressed throughout the cell cycle.
Cindy, Law, Peter, Cheung
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