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Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

The Chaperone NASP Contributes to de Novo Deposition of the Centromeric Histone Variant CENH3 in Arabidopsis Early Embryogenesis. [PDF]

Plant Cell Physiol
Takeuchi H, Nagahara S, Higashiyama T, Berger F.   +3 more
europepmc   +1 more source

Role of the histone variant H2A.Z.1 in memory, transcription, and alternative splicing is mediated by lysine modification. [PDF]

Neuropsychopharmacology
Reda A, Hategan LA, McLean TAB, Creighton SD, Luo JQ, Chen SES, Hua S, Winston S, Reeves I, Padmanabhan A, Dahi TA, Ramzan F, Brimble MA, Murphy PJ, Walters BJ, Stefanelli G, Zovkic IB.   +16 more
europepmc   +1 more source

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Histone Variants and Histone Modifications in Neurogenesis

Trends in Cell Biology, 2020
During embryonic brain development, neurogenesis requires the orchestration of gene expression to regulate neural stem cell (NSC) fate specification. Epigenetic regulation with specific emphasis on the modes of histone variants and histone post-translational modifications are involved in interactive gene regulation of central nervous system (CNS ...
Mengtian Zhang, Jinyue Zhao, Yuqing Lv, Wenwen Wang, Chao Feng, Wenzheng Zou, Libo Su, Jianwei Jiao   +7 more
openaire   +2 more sources

The modification and variants of histone

Molecular Biology, 2007
The modification of histone plays a crucial role in regulating chromatin states that conserve transcription programs and provide a mechanism for chromatin states to be maintained as cells proliferate. A large number of factors and protein complexes are now known to be involved in regulating the dynamic states of the modification and variants of histone.
Changjun, Mu, Heng, Liu, Guo-Chang, Zheng   +2 more
openaire   +2 more sources

Primate-specific histone variants

Genome, 2021
Canonical histones (H2A, H2B, H3, and H4) are present in all eukaryotes where they package genomic DNA and participate in numerous cellular processes, such as transcription regulation and DNA repair. In addition to the canonical histones, there are many histone variants, which have different amino acid sequences, possess tissue-specific expression ...
Ding, Dongbo, Nguyen, Thi Thuy, Pang, Yu Hin, Ishibashi, Toyotaka   +3 more
openaire   +3 more sources

Histone variants and histone modifications: A structural perspective

Biochemistry and Cell Biology, 2001
In this review, we briefly analyze the current state of knowledge on histone variants and their posttranslational modifications. We place special emphasis on the description of the structural component(s) defining and determining their functional role. The information available indicates that this histone "variability" may operate at different levels:
J, Ausió, D W, Abbott, X, Wang, S C, Moore   +3 more
openaire   +2 more sources

Analysis of Histones and Histone Variants in Plants

2011
Histone proteins are the major protein components of chromatin - the physiologically relevant form of the genome (or epigenome) in all eukaryotic cells. For many years, histones were considered passive structural components of eukaryotic chromatin. In recent years, it has been demonstrated that dynamic association of histones and their variants to the ...
Ila, Trivedi, Krishan Mohan, Rai, Sunil Kumar, Singh, Verandra, Kumar, Mala, Singh, Amol, Ranjan, Niraj, Lodhi, Samir V, Sawant   +7 more
openaire   +2 more sources

Histone Variants in Development and Diseases

Journal of Genetics and Genomics, 2013
Eukaryotic genomic DNA is highly packaged into chromatin by histones to fit inside the nucleus. Other than the bulk packaging role of canonical histones with an expression peak at S phase and replication-coupled deposition, different histone variants have evolved distinct regulatory mechanisms for their expression, deposition and functional ...
Ping, Chen, Jicheng, Zhao, Guohong, Li
openaire   +2 more sources

Histone Variants Meet Their Match

Nature Reviews Molecular Cell Biology, 2005
A fascinating aspect of how chromatin structure impacts on gene expression and cellular identity is the transmission of information from mother to daughter cells, independently of the primary DNA sequence. This epigenetic information seems to be contained within the covalent modifications of histone polypeptides and the distinctive characteristics of ...
Danny Reinberg
exaly   +3 more sources