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In and out: histone variant exchange in chromatin
Trends in Biochemical Sciences, 2005Alterations in nucleosome structure affect the accessibility of the DNA and can generate specialized domains of chromatin in the genome. Such changes can be introduced by posttranslational modifications of histones, by chromatin remodeling, or by the incorporation of variants of H2A and H3 into nucleosomes.
Jingji, Jin +6 more
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Histone variants in mouse centromeric chromatin
Molecular and Cellular Biochemistry, 1989Highly purified centromeric heterochromatin was isolated from mouse liver nuclei and the pattern of core histone variants was analyzed. In comparison with total chromatin, the centromeric heterochromatin of young animals was characterized by (1) enrichment in the replication-dependent variants H2A1, H2B2 and H3(2), (2) reduced amount of the minor ...
V, Russanova +3 more
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Environmental responses mediated by histone variants
Trends in Cell Biology, 2014Fluctuations in the ambient environment can trigger chromatin disruptions, involving replacement of nucleosomes or exchange of their histone subunits. Unlike canonical histones, which are available only during S-phase, replication-independent histone variants are present throughout the cell cycle and are adapted for chromatin repair.
Paul B, Talbert, Steven, Henikoff
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2004
Publisher Summary The structure of the nucleosome can be adapted to specialized functions by altering its histone composition. In higher eukaryotes, all of the core histones except H4 exist in multiple variant forms that have different primary structures.
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Publisher Summary The structure of the nucleosome can be adapted to specialized functions by altering its histone composition. In higher eukaryotes, all of the core histones except H4 exist in multiple variant forms that have different primary structures.
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Histone variants: The architects of chromatin
Seminars in Cell & Developmental Biology, 2023openaire +2 more sources
Experimental Approaches Toward Histone Acetyltransferase Modulators as Therapeutics
Medical Epigenetics, 2021exaly
Critical Role of the HP1-Histone Methyltransferase Pathways in Cancer Epigenetics
Medical Epigenetics, 2013Gwen Lomberk +2 more
exaly