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2018
In eukaryotes, the genome is organized into a complex nucleoprotein structure called chromatin. Despite the simplicity of its monomer, DNA and two copies of four histones, the existence of histone variants opens possibilities of multiple chromatin landscapes and fine-tune regulation of molecular mechanisms for the regulation of gene expression and ...
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In eukaryotes, the genome is organized into a complex nucleoprotein structure called chromatin. Despite the simplicity of its monomer, DNA and two copies of four histones, the existence of histone variants opens possibilities of multiple chromatin landscapes and fine-tune regulation of molecular mechanisms for the regulation of gene expression and ...
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H 1 histone and histone variants in Trypanosoma cruzi
Experimental Cell Research, 1988Trypanosoma cruzi chromatin is not condensed in chromosomes during mitosis. In previous studies a characteristic H 1 was not found in SDS or in acid-urea-PAGE. Consequently, it was proposed that the particular behavior of T. cruzi chromatin in dividing cells was due to the absence of an H 1 histone. In the present work, histones from this parasite were
G C, Toro, N, Galanti
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[Histone variants and histone exchange].
Yi chuan = Hereditas, 2009Histones, as the basic components of nucleosome, are essential to chromatin structure and function. To adapt to various states of chromatin, corresponding histone variants are incorporated in nucleosome, and certain modifications also occur on the variants' tails.
Nan, Wu, Jian-Fang, Gui
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Histone Variants and Transcription Regulation
2012Histones are the protein components of chromatin and are important for its organization and compaction. Although core histones are exclusively expressed during S phase of the cell cycle, there exist variants of canonical histones that are expressed throughout the cell cycle.
Cindy, Law, Peter, Cheung
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Histone Variants in Development and Diseases
Journal of Genetics and Genomics, 2013Eukaryotic genomic DNA is highly packaged into chromatin by histones to fit inside the nucleus. Other than the bulk packaging role of canonical histones with an expression peak at S phase and replication-coupled deposition, different histone variants have evolved distinct regulatory mechanisms for their expression, deposition and functional ...
Ping, Chen, Jicheng, Zhao, Guohong, Li
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Histone variants: nuclear function and disease
Current Opinion in Genetics & Development, 2016Histone variants have emerged as important contributors to the regulation of chromatin structure and therefore of almost all DNA-based processes. Hence, these specialized proteins play important roles in transcriptional regulation, cell cycle progression, DNA repair, chromatin stability, chromosome segregation and apoptosis.
Lisa-Maria, Zink, Sandra B, Hake
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Analysis of Histones and Histone Variants in Plants
2011Histone proteins are the major protein components of chromatin - the physiologically relevant form of the genome (or epigenome) in all eukaryotic cells. For many years, histones were considered passive structural components of eukaryotic chromatin. In recent years, it has been demonstrated that dynamic association of histones and their variants to the ...
Ila, Trivedi +7 more
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Histone variants in plant transcriptional regulation
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2017Chromatin based organization of eukaryotic genome plays a profound role in regulating gene transcription. Nucleosomes form the basic subunits of chromatin by packaging DNA with histone proteins, impeding the access of DNA to transcription factors and RNA polymerases.
Danhua, Jiang, Frédéric, Berger
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2004
Publisher Summary The structure of the nucleosome can be adapted to specialized functions by altering its histone composition. In higher eukaryotes, all of the core histones except H4 exist in multiple variant forms that have different primary structures.
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Publisher Summary The structure of the nucleosome can be adapted to specialized functions by altering its histone composition. In higher eukaryotes, all of the core histones except H4 exist in multiple variant forms that have different primary structures.
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The modification and variants of histone
Molecular Biology, 2007The modification of histone plays a crucial role in regulating chromatin states that conserve transcription programs and provide a mechanism for chromatin states to be maintained as cells proliferate. A large number of factors and protein complexes are now known to be involved in regulating the dynamic states of the modification and variants of histone.
Changjun, Mu +2 more
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