Results 11 to 20 of about 67,934 (145)

Histopathological growth patterns of neuroendocrine tumor liver metastases. [PDF]

Clin Exp Metastasis, 2023
AbstractHistopathological growth patterns (HGPs) of liver metastases represent a potential biomarker for prognosis after resection. They have never been studied in neuroendocrine tumor liver metastases (NETLM). This study evaluated if distinct HGPs can be observed in resected NETLM and if they have prognostic value.
Meyer Y, Bohlok A, Olthof P, Donckier V, Doukas M, Lucidi V, Vermeulen P, Grünhagen D, Verhoef C.   +8 more
europepmc   +11 more sources

Histopathological Growth Patterns and Survival After Resection of Colorectal Liver Metastasis: An External Validation Study. [PDF]

JNCI Cancer Spectr, 2021
Abstract Background After resection of colorectal cancer liver metastases (CRLM), 2 main histopathological growth patterns can be observed: a desmoplastic and a nondesmoplastic subtype. The desmoplastic subtype has been associated with superior survival. These findings require external validation.
Höppener DJ, Galjart B, Nierop PMH, Buisman FE, van der Stok EP, Coebergh van den Braak RRJ, van Amerongen MJ, Balachandran VP, Jarnagin WR, Kingham TP, Doukas M, Shia J, Nagtegaal ID, Vermeulen PB, Koerkamp BG, Grünhagen DJ, de Wilt JHW, D'Angelica MI, Verhoef C.   +18 more
europepmc   +10 more sources

Differentiation of histopathological growth patterns of colorectal liver metastases by MRI features. [PDF]

Quant Imaging Med Surg, 2022
It is necessary to develop an accurate non-invasive method to determine the histopathological growth pattern (HGP) of colorectal liver metastasis (CRLM) before surgery. The present study aimed to identify various HGPs of CRLM by magnetic resonance imaging (MRI) features.This retrospective study included 53 chemo-naïve patients with CRLM between ...
Li WH, Wang S, Liu Y, Wang XF, Wang YF, Chai RM.   +5 more
europepmc   +5 more sources

Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights. [PDF]

Br J Cancer, 2022
The first consensus guidelines for scoring the histopathological growth patterns (HGPs) of liver metastases were established in 2017. Since then, numerous studies have applied these guidelines, have further substantiated the potential clinical value of the HGPs in patients with liver metastases from various tumour types and are starting to shed light ...
Latacz E, Höppener D, Bohlok A, Leduc S, Tabariès S, Fernández Moro C, Lugassy C, Nyström H, Bozóky B, Floris G, Geyer N, Brodt P, Llado L, Van Mileghem L, De Schepper M, Majeed AW, Lazaris A, Dirix P, Zhang Q, Petrillo SK, Vankerckhove S, Joye I, Meyer Y, Gregorieff A, Roig NR, Vidal-Vanaclocha F, Denis L, Oliveira RC, Metrakos P, Grünhagen DJ, Nagtegaal ID, Mollevi DG, Jarnagin WR, D'Angelica MI, Reynolds AR, Doukas M, Desmedt C, Dirix L, Donckier V, Siegel PM, Barnhill R, Gerling M, Verhoef C, Vermeulen PB.   +43 more
europepmc   +8 more sources

Histopathological Growth Pattern in Colorectal Liver Metastasis and The Tumor Immune Microenvironment [PDF]

Cancers, 2022
Almost half of all patients with colorectal cancer present with or eventually develop metastasis, most frequently in the liver. Understanding the histopathological growth patterns and tumor immune microenvironment of colorectal liver metastases may help determine treatment strategies and assess prognosis.
Claudia Zaharia, Torhild Veen, Dordi Lea, Arezo Kanani, Marina Alexeeva, Kjetil Søreide   +5 more
openaire   +5 more sources

International consensus guidelines for scoring the histopathological growth patterns of liver metastasis. [PDF]

Br J Cancer, 2017
Liver metastases present with distinct histopathological growth patterns (HGPs), including the desmoplastic, pushing and replacement HGPs and two rarer HGPs. The HGPs are defined owing to the distinct interface between the cancer cells and the adjacent normal liver parenchyma that is present in each pattern and can be scored from standard haematoxylin ...
van Dam PJ, van der Stok EP, Teuwen LA, Van den Eynden GG, Illemann M, Frentzas S, Majeed AW, Eefsen RL, Coebergh van den Braak RRJ, Lazaris A, Fernandez MC, Galjart B, Laerum OD, Rayes R, Grünhagen DJ, Van de Paer M, Sucaet Y, Mudhar HS, Schvimer M, Nyström H, Kockx M, Bird NC, Vidal-Vanaclocha F, Metrakos P, Simoneau E, Verhoef C, Dirix LY, Van Laere S, Gao ZH, Brodt P, Reynolds AR, Vermeulen PB.   +31 more
europepmc   +11 more sources

Histopathological growth patterns and positive margins after resection of colorectal liver metastases. [PDF]

HPB (Oxford), 2020
Histopathological growth patterns (HGPs) of colorectal liver metastases (CRLM) may be an expression of biological tumour behaviour impacting the risk of positive resection margins. The current study aimed to investigate whether the non-desmoplastic growth pattern (non-dHGP) is associated with a higher risk of positive resection margins after resection ...
Nierop PMH, Höppener DJ, van der Stok EP, Galjart B, Buisman FE, Balachandran VP, Jarnagin WR, Kingham TP, Allen PJ, Shia J, Vermeulen PB, Groot Koerkamp B, Grünhagen DJ, Verhoef C, D'Angelica MI.   +14 more
europepmc   +5 more sources

Histopathological growth patterns of colorectal liver metastasis exhibit little heterogeneity and can be determined with a high diagnostic accuracy. [PDF]

Clin Exp Metastasis, 2019
Colorectal liver metastases (CRLM) exhibit distinct histopathological growth patterns (HGPs) that are indicative of prognosis following surgical treatment. This study aims to assess the reliability and replicability of this histological biomarker. Within
Höppener DJ, Nierop PMH, Herpel E, Rahbari NN, Doukas M, Vermeulen PB, Grünhagen DJ, Verhoef C.   +7 more
europepmc   +4 more sources

Transcriptomic characterization of the histopathological growth patterns in breast cancer liver metastases. [PDF]

Clin Exp Metastasis, 2023
Abstract Metastatic breast cancer (mBC) remains incurable and liver metastases (LM) are observed in approximately 50% of all patients with mBC. In some cases, surgical resection of breast cancer liver metastases (BCLM) is associated with prolonged survival.
Leduc S, Nguyen HL, Richard F, Zels G, Mahdami A, De Schepper M, Maetens M, Pabba A, Jaekers J, Latacz E, Bohlok A, Vanderheyden E, Van Brussel T, Boeckx B, Schepers R, Lambrechts D, Dirix L, Larsimont D, Vankerckhove S, Lucidi V, Topal B, Bachir I, Donckier V, Floris G, Vermeulen P, Desmedt C.   +25 more
europepmc   +5 more sources

Histopathological growth patterns as biomarker for adjuvant systemic chemotherapy in patients with resected colorectal liver metastases. [PDF]

Clin Exp Metastasis, 2020
Adjuvant systemic chemotherapy (CTx) is widely administered in patients with colorectal liver metastases (CRLM). Histopathological growth patterns (HGPs) are an independent prognostic factor for survival after complete resection.
Buisman FE, van der Stok EP, Galjart B, Vermeulen PB, Balachandran VP, Coebergh van den Braak RRJ, Creasy JM, Höppener DJ, Jarnagin WR, Kingham TP, Nierop PMH, Sadot E, Shia J, Groot Koerkamp B, Grünhagen DJ, D'Angelica M, Verhoef C.   +16 more
europepmc   +4 more sources