Results 61 to 70 of about 100,216 (309)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Historical thinking skills with digital resources : causes, consequences, change and continuity
, 2023 As part of the topics dedicated to Travels and travellers: economic, social and cultural connections and Churches and Religion – historical paths of long duration and transversal to the content addressed in the traditional textbooks, in adherence to the ...
F. Galletti, M. Ghizzoni, B. Borghi
core +1 more source
Formation of Artistic Historicism in the Early Work of I. I. Lazhechnikov
Научный диалог, 2020 The article is devoted to the formation of artistic historicism in the work of Lazhechnikov. The relevance of the study is associated with the need for a deeper study of the early work of the writer.
S. M. Isupova
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Historical thinking competences education [PDF]
, 2013 Este artículo presenta una propuesta para la formación de competencias de pensamiento histórico. 1) La conciencia histórica-temporal relacionada con la temporalidad humana, el cambio y el poder sobre el tiempo futuro.
Santisteban Fernandez, Antoni
core
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
, 2023 In this article, the author reveals the structure of the formation of historical thinking in the future history teacher based on a comprehensive approach to the study of historical sciences.
Rimma Ramilevna Zamilova
core +1 more source
Stimulating historical thinking in a classroom discussion: The role of the teacher
Historical Encounters: A Journal of Historical Consciousness, Historical Cultures, and History Education, 2017 In this article we describe strategies history teachers use to guide student historical thinking in a classroom discussion. We focus on three challenges for the teacher: a) exploring several possible answers; b) stimulating the use of specialized ...
Harry Havekes +3 more
doaj +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source