Results 41 to 50 of about 56,272 (257)

Thinking With Universal Designing in Historical Environment

Iconarp International J. of Architecture and Planning, 2018
All sorts of values which are regarded as world heritage such as natural fields, monuments and sites under protection on a local scale are pieces of cultural identity and they are irreplaceable. The environment especially consists of historical structures have significant place in protection policies since they generally host daily life activities ...
Tutal, Osman, Topçu, Mehmet
openaire   +5 more sources

Intercultural Historical Thinking and its Sense in the History of Civilization

História da Historiografia
This article explores the importance of intercultural historical thinking in the age of globalization and its significance to the historical study of civilization. The article points out that in the context of globalization, human beings are still faced
Yu Peiyun
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Implementation of Experiential Learning to Enhance Students' Historical Thinking Skills

Qalamuna
This study explores the implementation of Experiential Learning in enhancing students' historical thinking skills. Historical thinking is a critical competency that enables students to analyze, interpret, and critically evaluate historical events ...
Haris Firmansyah, Astrini Eka Putri, Hadi Wiyono   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A systematic review of pedagogical interventions on the learning of historical literacy in schools

History Education Research Journal, 2023
Over the past thirty years, there has been a growing body of research investigating the efficacy of pedagogical interventions to enhance the historical literacy skills of primary and secondary school students.
doaj   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Formation of Artistic Historicism in the Early Work of I. I. Lazhechnikov

Научный диалог, 2020
The article is devoted to the formation of artistic historicism in the work of Lazhechnikov. The relevance of the study is associated with the need for a deeper study of the early work of the writer.
S. M. Isupova
doaj   +1 more source