Results 81 to 90 of about 100,216 (309)
A situated approach to historical thinking in the Australian Curriculum : History
, 2012 This paper focuses on the importance of foregrounding an emphasis on the development of historical thinking in the implementation of the Australian Curriculum: History as a way of making the study of history meaningful for their students. In doing so, it
Henderson, Deborah J.
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Popular uses of violent pasts and historical thinking ( Los usos populares de los pasados violentos y el razonamiento histórico ) [PDF]
, 2020 María Grever, Karel Van Nieuwenhuyse
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Problems of Formation of Historical Memory and Historical Thinking in the Mind of Youth
, 2022 This article is a socio-philosophical study of the historical thinking of young people, the development of proposals and recommendations aimed at developing the historical thinking and historical memory of the youth of our ...
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Resilience and higher order thinking
, 2010 To appreciate, understand, and tackle chronic global social and environmental problems, greater appreciation of the importance of higher order thinking is required.
Fazey, Ioan Raymond Albert
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Questions Vives, 2016 Researches in history education has developed partly by comparison with science education. Learning historical thinking has thus been an epistemological way to figure out how to handle critical and civic aims of history teaching, and what is history’s ...
Sylvain Doussot, Anne Vézier
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