Results 101 to 110 of about 1,367,711 (304)

Project strategies of political thought: meta-scientific dominants [PDF]

, 2015
This paper deals with the problem of philosophical and scientific (epistemological) reflection of the value assumptions in political thinking. The authors of the paper use the concept of civic consciousness to demonstrate the relationship of historical ...
Olkhov, P. A., Polukhin, O. N.
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Exploring the Educational Potential of a Video-Interview with a Shoah Survivor

Genocide Studies and Prevention: An International Journal, 2017
This article aims to establish what the education potential is of video-interviews with Shoah survivors that have been made available as historical sources for learners in secondary schools.
Katalin Eszter Morgan
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Enhancing historical thinking in school. An integrated model (content, categories, skills) for identifying and assessing learning objectives

Ricerche di Pedagogia e Didattica
The question of history learning at school and its improvement has long been a subject of discussion, but it continues to present unresolved critical issues due to pupils’ difficulties in understanding this discipline, difficulties in defining clear and ...
Valentina Della Gala, Antonio Calvani
doaj   +1 more source

Memory on Parade: The Gallipoli Centenary and Anzac Day Commemoration

, 2015
On April 25, 2015, record crowds were drawn from across Australia and New Zealand to the annual Anzac Day celebrations. This year’s commemoration was extra special, for it marked the one hundredth anniversary of the First World War’s Gallipoli campaign ...
Lavery, Kevin P.
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Future long-range transports: Prospects for improved fuel efficiency [PDF]

A status report is provided on current thinking concerning potential improvements in fuel efficiency and possible alternate fuels. Topics reviewed are: (1) historical trends in airplane efficiency; (2) technological opportunities including supercritical ...
Alford, W. J., Jr., Dugan, J. F., Jr., Nagel, A. L.   +2 more
core   +1 more source

The material origin of numbers: Insights from the archaeology of the Ancient Near East [PDF]

, 2019
What are numbers, and where do they come from? A novel answer to these timeless questions is proposed by cognitive archaeologist Karenleigh A. Overmann, based on her groundbreaking study of material devices used for counting in the Ancient Near East ...
Overmann, Karenleigh Anne
core