Results 101 to 110 of about 100,216 (309)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Assessment of historical thinking in secondary schools

, 2021
Promoting the ability to think historically is one of the central domains in developing pupils’ historical understanding. Despite a sound body of research on theoretical framework of historical thinking and teaching to think historically, a commonly ...
Karatas, Emre
core  

Historiology: Outline of a theory of historiology

Memoria y Civilización, 2012
The article analyzes historical thinking and emphasizes its specific form of historical studies. It explicates historical thinking as a mental and spiritual process of making sense of time by referring to the experience of the past.
Jörn Rüsen
doaj  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

salient features of chinese historical thinking

, 2006
Imbued with profound historical consciousness, the Chinese people are Homo Historiens in every sense of the term. To be human in China, to a very large extent, is to be historical which means to live up to the paradigmatic past today.
Huang, chun-chieh
core  

Historical Thinking and the Human

, 2020
Tamm M, Simon ZB, eds. Historical Thinking and the Human. Journal of the Philosophy of History.
Tamm, Marek, Simon, Zoltán Boldizsár ; https://orcid.org/   +1 more
core  

Enhancing historical thinking in school. An integrated model (content, categories, skills) for identifying and assessing learning objectives

Ricerche di Pedagogia e Didattica
The question of history learning at school and its improvement has long been a subject of discussion, but it continues to present unresolved critical issues due to pupils’ difficulties in understanding this discipline, difficulties in defining clear and ...
Valentina Della Gala, Antonio Calvani
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Thinking about historical thinking in the Australian Curriculum: History [PDF]

, 2012
© 2012 Gerard Francis MartinThis study analyses and evaluates the approach to historical thinking in the Australian Curriculum: History. This research study adopts interpretative discipline based pedagogy, with a document content analysis method.
Martin, Gerard Francis
core