Results 71 to 80 of about 53,579 (243)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Historiology: Outline of a theory of historiology

Memoria y Civilización, 2012
The article analyzes historical thinking and emphasizes its specific form of historical studies. It explicates historical thinking as a mental and spiritual process of making sense of time by referring to the experience of the past.
Jörn Rüsen
doaj  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

What If I Were the Exile? Linking Past and Present for Democratic History Teaching with Pre-Service Educators

Education Sciences
The academic literature has fostered a debate in recent decades regarding the concept of historical empathy and the typology of activities that can help to treat and develop it, although there is no consensus as to the real effectiveness of narrative ...
María Belén San Pedro Veledo, María Luisa Zagalaz-Sánchez, Carmen González González de Mesa   +2 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Historical literacy and contradictory evidence in a Finnish high school setting: The Bronze Soldier of Tallinn

Historical Encounters: A Journal of Historical Consciousness, Historical Cultures, and History Education, 2016
This article revolves around three key issues. Firstly, Finnish national core curriculum fixes the focus of history teaching to students' critical and historical thinking skills and the traditional approach to history teaching as memorizing of facts and ...
Anna Veijola, Simo Mikkonen
doaj  

Pengaruh Penggunaan Media Pembelajaran Wordwall untuk Meningkatkan Minat Belajar dan Berpikir Sejarah Peserta Didik di SMA Negeri 7 Bandung

Fajar Historia: Jurnal Ilmu Sejarah dan Pendidikan
History learning is one of the subjects that students are less interested in because it discusses space and time in the past. With the lack of interest in learning history affects the historical thinking of students which can be seen from the low ...
Thalia Natasya Syarief, Tarunasena Tarunasena, Yeni Kurniawati   +2 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

THE OPERATIONAL COMPONENT AND THE FORMATION OF A HISTORICAL CULTURE [PDF]

Varela, 2018
The formation of a historical culture is a process by which the conscious appropriation of a conception allows to operate in the cognitive, attitudinal and evaluative areas is produced, illustrating in its context ...
Lainy Rodríguez Hurtado, Lorenzo Alonso Gallardo, Ileana María Echevarría Aldama   +2 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source