Results 71 to 80 of about 1,357,671 (290)

Remnants of the past, history and the present. [PDF]

, 2004
The article interprets that it is hardly surprising then that philosophers of history point to the slender relationship between the raw facts of the past and understanding the past.
Booth, Douglas
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Thinking historically about public health

Medical Humanities, 2007
This paper argues that analysing past public health policies calls for scholarship that integrates insights not just from medical history but from a broad range of historical fields. Recent studies of historic infectious disease management make this evident: they confirm that prior practices inhere in current perceptions and policies, which, like their
Bashford, A., Strange, C.
openaire   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Do Curricula inspire historical thinking? [PDF]

Public History Weekly, 2014
In recent years, German-speaking history didactics has once again focused on curricula and syllabuses (after a lengthy lull in the 1990s). The Swiss “Lehrplan 21” project has demonstrated how controversial curricular issues remain to this day. In post-PISA Germany, many new curricula have also been developed, frequently aiming high by trying to outline
openaire   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Fatal attraction: a critique of Carl Schmitt's international political and legal theory [PDF]

, 2011
The ongoing Schmitt revival has extended Carl Schmitt's reach over the fields of international legal and political theory. Neo-Schmittians suggest that his international thought provides a new reading of the history of international law and order, which ...
Agamben, Anderson, Anderson, Balakrishnan, Bendersky, Benno Gerhard Teschke, Bonney, Brenner, Brewer, Brewer, Brown, Cocker, Colas, De Benoist, Diner, Diner, Downing, Fisch, Gowan, Habermas, Habermas, Haggenmacher, Hardt, Holmes, Joerges, Kelsen, Kervégan, Kunisch, Körner, Lilla, Marx, Mehring, Miller, Mouffe, Mouffe, Mouffe, Müller, O'Brien, Odysseos, Odysseos, Odysseos, Ojakangas, Opitz, Parker, Petito, Rasch, Repgen, Rüthers, Rüthers, Scheuerman, Scheuerman, Scheuerman, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmoeckel, Schroeder, Shapiro, Smith, Stirk, Stirk, Teschke, Tilly, Tooze, Wehler, Wolf, Wood, Wood, Wright, Zolo, Zolo, Žižek   +78 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

An assessment of 4th and 7th grade social studies instruction in terms of historical thinking skills [PDF]

, 2005
The latest approach to history education requires that students should be educated not as passive recipients of encyclopedic knowledge but as empowered individuals playing an active role in the knowledge generation process.
Caydas, Erinc, Iflazoglu, Ayten
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