Results 101 to 110 of about 56,319 (181)

HIV-1 Transcription and Latency in the Spotlight

Viruses
At every integrated HIV-1 genome, there is a transcriptional cycle that ultimately shapes proviral fate [...]
openaire   +3 more sources

HIV-1 accessory protein Vpr possesses a cryptic p300-dependent transcription-promoting activity that is blocked by histone deacetylases in CD4+ T cells.

PLoS Pathogens
Antiretroviral therapy (ART) has dramatically improved the clinical prognosis for people with HIV and prevents HIV transmission. However, ART does not cure HIV infection because of a persistent, latent viral reservoir in long-lived cells such as central ...
Catherine A Lewis, David M Margolis, Edward P Browne   +2 more
doaj   +1 more source

Transcriptional Stochasticity as a Key Aspect of HIV-1 Latency. [PDF]

Viruses, 2023
Damour A, Slaninova V, Radulescu O, Bertrand E, Basyuk E.   +4 more
europepmc   +1 more source

Lithium attenuates HIV-1 latency reversal in an autophagy-independent way. [PDF]

iScience
Abdalla AL, Guajardo-Contreras G, Chau BA, Niu M, Murooka T, Mouland AJ.   +5 more
europepmc   +1 more source

Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activity. [PDF]

Eur J Med Chem, 2023
Ishii T, Kobayakawa T, Matsuda K, Tsuji K, Ohashi N, Nakahata S, Noborio A, Yoshimura K, Mitsuya H, Maeda K, Tamamura H.   +10 more
europepmc   +1 more source

The crosstalk between ubiquitination and GlcNAcylation of CHAF1A regulates HIV-1 latency and reactivation. [PDF]

J Virol
Yang T, Chen M, Zhou M, Deng X, Huang P, Xie S, Zeng J, Luo J, Zhang Y, Ma X, Sun L, Liu J, Zhang H, Li L, Liu B, Qin J, Pan T.   +16 more
europepmc   +1 more source

PRMT2 promotes HIV-1 latency by preventing nucleolar exit and phase separation of Tat into the Super Elongation Complex. [PDF]

Nat Commun, 2023
Jin J, Bai H, Yan H, Deng T, Li T, Xiao R, Fan L, Bai X, Ning H, Liu Z, Zhang K, Wu X, Liang K, Ma P, Gao X, Hu D.   +15 more
europepmc   +1 more source

BRD9 functions as an HIV-1 latency regulatory factor. [PDF]

Proc Natl Acad Sci U S A
Luk TY, Yim LY, Zhou R, Mo Y, Huang H, Zhao M, Dai J, Lau TT, Huang X, Lui GC, Yuen KY, Chan JF, Cheng AS, Chen Z, Chu H.   +14 more
europepmc   +1 more source

AP-1/c-Fos supports SIV and HIV-1 latency in CD4 T cells infected in vivo. [PDF]

iScience, 2023
Cobos Jiménez V, Geretz A, Tokarev A, Ehrenberg PK, Deletsu S, Machmach K, Mudvari P, Howard JN, Zelkoski A, Paquin-Proulx D, Del Prete GQ, Subra C, Boritz EA, Bosque A, Thomas R, Bolton DL.   +15 more
europepmc   +1 more source

Targeted bacteriophage T4 nanoparticles reverse HIV-1 latency in human T cell line models. [PDF]

iScience
Batra H, Zhu J, Jain S, Ananthaswamy N, Mahalingam M, Tao P, Lange C, Hill S, Zhong C, Kearney MF, Hu H, Maldarelli F, Rao VB.   +12 more
europepmc   +1 more source