Results 241 to 250 of about 30,551,261 (265)

Unravelling HIV-1 Latency, One Cell at a Time

Trends in Microbiology, 2017
A single virus is capable of infecting and replicating in a single cell. Recent advances across single-cell omics technologies - genomics, epigenomics, transcriptomics, epitranscriptomics, proteomics, and metabolomics - will offer unprecedented opportunities to gain more insights into the various aspects of the life cycle of viruses and their impact on
Kok, Yik Lim, Ciuffi, Angela, Metzner, Karin J   +2 more
openaire   +4 more sources

Current views on HIV-1 latency, persistence, and cure

Folia Microbiologica, 2016
HIV-1 infection cannot be cured as it persists in latently infected cells that are targeted neither by the immune system nor by available therapeutic approaches. Consequently, a lifelong therapy suppressing only the actively replicating virus is necessary.
Zora, Melkova, Prakash, Shankaran, Michaela, Madlenakova, Josef, Bodor   +3 more
openaire   +2 more sources

Role of Mirna in HIV-1 Latency

Future HIV Therapy, 2008
Postintegration latency of HIV-1 is achieved when host cells contain integrated provirus but viral particles are not being produced. When the cells are activated, infectious viruses can be produced from the cells. Latent infection is one of the important characteristics for all HIV-1 strains to survive in vivo.
openaire   +1 more source

β-catenin regulates HIV latency and modulates HIV reactivation

PLoS Pathogens, 2022
Hannah J Barbian, Beverly E. Sha, Lena Al-Harthi   +2 more
exaly  

HIV-1 Latency and Viral Reservoirs: Existing Reversal Approaches and Potential Technologies, Targets, and Pathways Involved in HIV Latency Studies

Cells, 2021
Sushant Khanal, Madison Schank, Zhi Q Yao   +2 more
exaly  

CD8+ T cells promote HIV latency by remodeling CD4+ T cell metabolism to enhance their survival, quiescence, and stemness

Immunity, 2023
Deanna A Kulpa
exaly  

THE ROLE OF VPR IN HIV-1 LATENCY

Although antiretroviral therapy (ART) has dramatically improved the clinical prognosis for people with HIV and prevents transmission, ART is not a cure. This is because of a latent reservoir that persists in long-lived cells such as central memory CD4+ T (TCM) cells.
openaire   +1 more source

Multiply spliced HIV RNA is a predictive measure of virus production ex vivo and in vivo following reversal of HIV latency

EBioMedicine, 2021
Thomas A. Rasmussen, Steven G Deeks, Rachel Pascoe   +2 more
exaly  

On HIV-1 latency and viral reservoirs

2015
HIV-1 establishes a latent infection that is inaccessible to treatment in cellular and anatomical reservoirs. This thesis concerns several problematic issues of HIV-1 persistence, including ways to measure and monitor both the virus at low viral concentrations and the depletion of the reservoir.
openaire   +1 more source

The mTOR Complex Controls HIV Latency

Cell Host and Microbe, 2016
Michael C Bassik, Erik Verschueren, Warner C Greene   +2 more
exaly