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Current views on HIV-1 latency, persistence, and cure
Folia Microbiologica, 2016HIV-1 infection cannot be cured as it persists in latently infected cells that are targeted neither by the immune system nor by available therapeutic approaches. Consequently, a lifelong therapy suppressing only the actively replicating virus is necessary.
Zora, Melkova +3 more
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β-catenin regulates HIV latency and modulates HIV reactivation
PLoS Pathogens, 2022Hannah Barbian +2 more
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On HIV-1 latency and viral reservoirs
2015HIV-1 establishes a latent infection that is inaccessible to treatment in cellular and anatomical reservoirs. This thesis concerns several problematic issues of HIV-1 persistence, including ways to measure and monitor both the virus at low viral concentrations and the depletion of the reservoir.
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Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy
Nature, 2012, Mary F Kearney
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NF-κB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation
EMBO Journal, 2006Warner Greene +2 more
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