Results 231 to 240 of about 30,551,261 (265)

Underlying mechanisms of HIV-1 latency

Virus Genes, 2017
Similarly to other retroviruses, HIV-1 integrates its genome into the cellular chromosome. Expression of viral genes from the integrated viral DNA could then be regulated by the host genome. If the infected cell suppresses viral gene expression, the virus will undergo latency.
Bizhan Romani, Elham Allahbakhshi
openaire   +2 more sources

The multifactorial nature of HIV-1 latency

Trends in Molecular Medicine, 2004
HIV-1 can avoid host immune responses and antiretroviral drugs through the latent infection of resting memory CD4(+) T cells. Recently, latent viral genomes have been shown to reside within the introns of active host genes. Therefore, latency is not simply due to an inaccessibility of the integrated proviruses to the transcriptional machinery.
Kara, Lassen, Yefei, Han, Yan, Zhou, Janet, Siliciano, Robert F, Siliciano   +4 more
openaire   +2 more sources

Experimental approaches to the study of HIV-1 latency

Nature Reviews Microbiology, 2007
Viral latency is a reversibly non-productive state of infection that allows some viruses to evade host immune responses. As a consequence of its tropism for activated CD4(+) T cells, HIV-1 can establish latent infection in resting memory CD4(+) T cells, which are generated when activated CD4(+) T cells return to a quiescent state. Latent HIV-1 persists
Yefei, Han, Megan, Wind-Rotolo, Hung-Chih, Yang, Janet D, Siliciano, Robert F, Siliciano   +4 more
openaire   +2 more sources

HIV-1 Latency Is Maintained by the Estrogen Receptor

Trends in Microbiology, 2018
Persistence of the latent reservoir remains a challenge to curing HIV infection. Using shRNA screening, new insights into the molecular mechanisms underlying latency regulation indicate that the estrogen receptor is a potent repressor of proviral reactivation and may serve as a promising therapeutic target in combination with other latency-reversing ...
Alexis J, Bick, Janet P, Hapgood
openaire   +2 more sources

Molecular mechanisms of HIV-1 proviral latency

Expert Review of Anti-infective Therapy, 2005
While great strides have been made in the treatment of HIV infection with highly active antiretroviral therapy, an actual cure remains out of grasp. One confounding factor is the persistence of a small population of infected cells containing transcriptionally silent but reactivatable HIV proviruses.
Dwayne, Bisgrove, Mary, Lewinski, Frederic, Bushman, Eric, Verdin   +3 more
openaire   +2 more sources

The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo

PLoS Pathogens, 2015
Pharmacologically-induced activation of replication competent proviruses from latency in the presence of antiretroviral treatment (ART) has been proposed as a step towards curing HIV-1 infection. However, until now, approaches to reverse HIV-1 latency in humans have yielded mixed results.
Thomas A. Rasmussen, Martin Tolstrup, Ole Schmeltz Søgaard   +2 more
exaly   +9 more sources

Humanized Mouse Models of HIV-1 Latency

Current HIV Research, 2011
The existence of long-lasting cellular reservoirs of HIV-1 is one of the major hurdles in developing effective anti-retroviral therapies. These latently infected cells and tissues efficiently evade immune responses and remain dormant until activated, upon which they can generate a productive HIV-1 infection.
Duyne, Rachel V, Narayanan, Aarthi, K-Hall, Kylene, Saifuddin, Mohammed, Shultz, Leonard D, Kashanchi, Fatah   +5 more
openaire   +2 more sources

Reversal of Latency as Part of a Cure for HIV-1

Trends in Microbiology, 2016
Here, the use of pharmacological agents to reverse HIV-1 latency will be explored as a therapeutic strategy towards a cure. However, while clinical trials of latency-reversing agents LRAs) have demonstrated their ability to increase production of latent HIV-1, such interventions have not had an effect on the size of the latent HIV-1 reservoir ...
Rasmussen, Thomas Aagaard; id_orcid 0000-0001-5354-2442, Tolstrup, Martin; id_orcid 0000-0001-7020-5173, Søgaard, Ole Schmeltz   +2 more
openaire   +3 more sources

Therapeutics for HIV-1 reactivation from latency

Current Opinion in Virology, 2013
Intensive combined antiretroviral therapy successfully suppresses HIV-1 replication and AIDS disease progression making infection manageable, but it is unable to eradicate the virus that persists in long-lived, drug-insensitive and immune system-insensitive reservoirs thus asking for life-long treatments with problems of compliance, resistance ...
Marco, Sgarbanti, Angela, Battistini
openaire   +2 more sources

Roles of microRNAs in HIV-1 Replication and Latency

MicroRNA, 2016
MicroRNAs (miRNAs) are non-coding RNA molecules, with sequence length of 19-24 nucleotides, which can induce mRNA degradation and regulate protein translation repression. Recently plenty of reports showed that miRNAs increase or decrease in the serum (circulating miRNAs) and in PBMC of Human immunodeficiency virus type 1 (HIV-1) infected individuals to
Sun, Binlian, Yang, Rongge, MALLARDO, MASSIMO   +2 more
openaire   +3 more sources