Results 71 to 80 of about 56,319 (181)
EMBO Molecular Medicine, 2021 HIV‐1 infects lymphoid and myeloid cells, which can harbor a latent proviral reservoir responsible for maintaining lifelong infection. Glycolytic metabolism has been identified as a determinant of susceptibility to HIV‐1 infection, but its role in the ...
Iart Luca Shytaj +22 more
doaj +1 more source
Are BET Inhibitors yet Promising Latency-Reversing Agents for HIV-1 Reactivation in AIDS Therapy?
Viruses, 2021 AIDS first emerged decades ago; however, its cure, i.e., eliminating all virus sources, is still unachievable. A critical burden of AIDS therapy is the evasive nature of HIV-1 in face of host immune responses, the so-called “latency.” Recently, a ...
Thanarat Salahong +2 more
doaj +1 more source
Selective cell death of latently HIV-infected CD4+ T cells mediated by autosis inducing nanopeptides. [PDF]
, 2019 Despite significant advances in the treatment of human immunodeficiency virus type-1 (HIV) infection, antiretroviral therapy only suppresses viral replication but is unable to eliminate infection. Thus, discontinuation of antiretrovirals results in viral
Campbell, Grant R +6 more
core
MicroRNA-29 family expression and its relation to antiviral immune response and viro-immunological markers in HIV-1-infected patients [PDF]
, 2015 BACKGROUND: Several in vitro studies suggested the microRNA-29 (miRNA-29) family is involved in regulating HIV-1 and modulating the expression of interleukin (IL)-32, an anti-HIV-1 cytokine.
ANTONELLI, Guido +9 more
core +2 more sources
Epigenetic regulation of HIV-1 latency: focus on polycomb group (PcG) proteins
Clinical Epigenetics, 2018 HIV-1 latency allows the virus to persist until reactivation, in a transcriptionally silent form in its cellular reservoirs despite the presence of effective cART.
Sheraz Khan +4 more
doaj +1 more source
Low-Level HIV-I Replication and the Dynamics of the Resting CD4(+) T Cell Reservoir for HIV-I in the Setting of HAART [PDF]
, 2008 In the setting of highly active antiretroviral therapy (HAART), plasma levels of human immunodeficiency type-I (HIV-I) rapidly decay to below the limit of detection of standard clinical assays.
Sedaghat, Ahmad R. +2 more
core +1 more source
[Molecular basis of HIV-1 latency - Part II: HIV-1 reactivation and therapeutic implications].
Medecine sciences : M/S, 2010 La constitution de réservoirs pour le VIH-1 intégré de manière latente s’établit très précocement au cours de l’infection et constitue un obstacle majeur à son éradication. Celle-ci n’est ainsi envisageable que si une purge de ces réservoirs est associée à une multithérapie active.
Cherrier, Thomas +6 more
openaire +2 more sources
PLoS Pathogens, 2020 Recent efforts have been paid to identify previously unrecognized HIV-1 latency-promoting genes (LPGs) that can potentially be targeted for eradication of HIV-1 latent reservoirs. From our earlier orthologous RNAi screens of host factors regulating HIV-1
Weili Kong +6 more
doaj +1 more source
Viral dynamics of acute HIV-1 infection. [PDF]
, 1999 Viral dynamics were intensively investigated in eight patients with acute HIV infection to define the earliest rates of change in plasma HIV RNA before and after the start of antiretroviral therapy. We report the first estimates of the basic reproductive
Havlir, DV +4 more
core
Regulation of HIV-1 latency by T-cell activation [PDF]
Cytokine, 2007 HIV-infected patients harbor approximately 10(5)-10(6) memory CD4 T-cells that contain fully integrated but transcriptionally silent HIV proviruses. While small in number, these latently infected cells form a drug-insensitive reservoir that importantly contributes to the life-long persistence of HIV despite highly effective antiviral therapy. In tissue
Samuel A, Williams, Warner C, Greene
openaire +2 more sources