Results 91 to 100 of about 3,675 (177)

The Spatial Biology of HIV Transmission and Infection: Imaging the Female and Male Reproductive Tracts

American Journal of Reproductive Immunology, Volume 95, Issue 6, June 2026.
ABSTRACT HIV transmission through the female and male reproductive tracts is governed by spatially organized interactions between virions, epithelial barriers, and tissue‐resident immune cells. Imaging approaches have been central to defining these earliest events, progressing from classical histology and immunohistochemistry (IHC) to modern ...
Ann M. Carias, Claudia C. Stroupe, Thatiane Russo, Thomas J. Hope   +3 more
wiley   +1 more source

Noncanonical-NF-κB activation and DDX3 inhibition reduces the HIV-1 reservoir by elimination of latently infected cells ex-vivo

Microbiology Spectrum
Latency reversal and subsequent elimination of the human immunodeficiency virus-1 (HIV-1) reservoir using a combination of compounds with different mechanisms of action are considered a promising tool for HIV-1 cure.
Jade Jansen, Stefanie Kroeze, Shirley Man, Matteo Andreini, Jan-Willem Bakker, Claudio Zamperini, Alessia Tarditi, Neeltje A. Kootstra, Teunis B. H. Geijtenbeek   +8 more
doaj   +1 more source

Interleukin-2 is a potent latency reversal agent in people with treated HIV-1

Science Advances
Eliciting HIV-1 expression from latently infected CD4 + T cells allows these rare reservoir cells to become targets of the immune system and may also result in death of reservoir cells via virus-induced cytopathy.
Michael L. Freeman, Brian M. Clagett, Konstantin Leskov, Daniela Moisi, George A. Yendewa, Scott F. Sieg, Gregory M. Laird, Jonathan Karn, Jeffrey M. Jacobson, Benigno Rodriguez, Michael M. Lederman   +10 more
openaire   +3 more sources

The HIV Reservoir in the Female Reproductive Tract

American Journal of Reproductive Immunology, Volume 95, Issue 6, June 2026.
ABSTRACT Antiretrovirals can prevent the spread of replicating HIV within the host and decrease the virus in plasma to levels undetectable in clinical assays, and in genital secretions to untransmissible levels. However, during effective treatment with antiretrovirals, infectious HIV persists lifelong because the virus integrates into the host's DNA ...
Sean M. Hughes, Lisa M. Frenkel
wiley   +1 more source

Risk Factors for Pneumocystis Jirovecii Pneumonia Among Kidney Transplant Recipients in Southeast France: A 10 Years Case‐Control Study

Clinical Transplantation, Volume 40, Issue 6, June 2026.
ABSTRACT Background Pneumocystis jirovecii is an opportunistic fungus responsible for Pneumocystis pneumonia (PJP) in hosts with impaired cell‐mediated immunity, particularly solid organ transplant recipients. The aim of our study was to identify risk factors associated with PJP in kidney transplant recipients (KTRs).
Solenne Hulot, Raphaël Godefroy, Barbara Doudier, Léa Delorme, Sébastien Cortaredona, Catherine Sartor, Coralie L'Ollivier, Stéphane Burtey, Valérie Moal, Nadim Cassir   +9 more
wiley   +1 more source

Enhancing HIV-1 latency reversal through regulating the elongating RNA Pol II pause-release by a small-molecule disruptor of PAF1C. [PDF]

Sci Adv, 2023
Soliman SHA, Cisneros WJ, Iwanaszko M, Aoi Y, Ganesan S, Walter M, Zeidner JM, Mishra RK, Kim EY, Wolinsky SM, Hultquist JF, Shilatifard A.   +11 more
europepmc   +1 more source

The impact of accumulating immune adaptation in circulating strains of HIV‐1

HIV Medicine, Volume 27, Issue 6, Page 918-934, June 2026.
Abstract Background Mutations in human immunodeficiency virus type 1 (HIV‐1) enable the virus to evade recognition and killing by human leucocyte antigen (HLA)‐restricted T cells. These viral adaptations are specific to the HLA type of individuals and are therefore evident as HLA allele‐HIV sequence associations at the population level. Most studies of
Marwah Al‐kaabi, Alison Castley, Pooja Deshpande, Abha Chopra, David Nolan, Simon Mallal, Mina John, Silvana Gaudieri   +7 more
wiley   +1 more source

Catchet-MS identifies IKZF1-targeting thalidomide analogues as novel HIV-1 latency reversal agents. [PDF]

Nucleic Acids Res, 2022
Ne E, Crespo R, Izquierdo-Lara R, Rao S, Koçer S, Górska A, van Staveren T, Kan TW, van de Vijver D, Dekkers D, Rokx C, Moulos P, Hatzis P, Palstra RJ, Demmers J, Mahmoudi T.   +15 more
europepmc   +1 more source

The NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.
Bherouz Pourdad, Arash Pourdad
wiley   +1 more source

Targeted bacteriophage T4 nanoparticles reverse HIV-1 latency in human T cell line models

iScience
Summary: A major barrier for HIV-1 eradication is the latent virus reservoir containing stably integrated and silent proviruses in CD4+ T cells. Targeted reactivation and removal of this latent reservoir is a potential strategy for HIV-1 cure, but ...
Himanshu Batra, Jingen Zhu, Swati Jain, Neeti Ananthaswamy, Marthandan Mahalingam, Pan Tao, Camille Lange, Shawn Hill, Chaojie Zhong, Mary F. Kearney, Haitao Hu, Frank Maldarelli, Venigalla B. Rao   +12 more
doaj   +1 more source