Results 101 to 110 of about 29,994,236 (203)

Mathematical modeling and mechanisms of HIV latency for personalized anti latency therapies

npj Systems Biology and Applications
Combination antiretroviral therapy controls human immunodeficiency virus-1 (HIV) but cannot eradicate latent proviruses in immune cells, which reactivate upon treatment interruption.
Gianmarco Rasi, Elena Emili, Jessica M. Conway, Nicola Cotugno, Paolo Palma   +4 more
doaj   +1 more source

Latency Reversing Agents and the Road to an HIV Cure

Pathogens
HIV-1 infection cannot be cured due to the presence of HIV-1 latently infected cells. These cells do not produce the virus, but they can resume virus production at any time in the absence of antiretroviral therapy. Therefore, people living with HIV (PLWH)
Louis Tioka, Rafael Ceña Diez, Anders Sönnerborg, Maarten A. A. van de Klundert   +3 more
doaj   +1 more source

Chromatin maturation of the HIV-1 provirus in primary resting CD4+ T cells.

PLoS Pathogens, 2020
Human immunodeficiency virus type 1 (HIV-1) infection is a chronic condition, where viral DNA integrates into the genome. Latently infected cells form a persistent, heterogeneous reservoir that at any time can reactivate the integrated HIV-1.
Birgitta Lindqvist, Sara Svensson Akusjärvi, Anders Sönnerborg, Marios Dimitriou, J Peter Svensson   +4 more
doaj   +1 more source

Regulating critical technologies: National security and intellectual property

The Journal of World Intellectual Property, EarlyView.
Abstract In recent years, claims of ‘national security’ have surged internationally to protect various security interests including public health, economic security and cybersecurity. National industrial strategies for building critical technologies challenge the scope of ‘national security’ in international intellectual property (IP) protection ...
Phoebe Li, Atilla Kasap
wiley   +1 more source

Patterns of Drug Resistance, Drug Resistance Conferring Mutations and Genomic DNA Methylation Revealed in Mycobacterium tuberculosis From South Africa

Tropical Medicine &International Health, EarlyView.
ABSTRACT Tuberculosis remains a major public health threat globally, with drug‐resistant strains undermining treatment efficacy. We analyzed 126 Mycobacterium tuberculosis (M. tuberculosis) isolates with diverse drug resistance spectra and selected 35 for whole genome sequencing (WGS) using Illumina NextSeq, SMRT PacBio Onso and SMRT PacBio Revio ...
Unarine Matodzi, Awelani Mutshembele, Eric Mensah, Dillon Muzondiwa, Ndivhuho A. Makhado, Oleg N. Reva   +5 more
wiley   +1 more source

Polyomavirus Drives Cerebellar Lesions in AIDS Monkeys With Ataxia

MedComm, Volume 7, Issue 11, November 2026.
Chronic SIV‐infected macaques with ataxia develop severe cerebellar lesions driven by simian polyomavirus 40 (SV40) infection. SV40 preferentially infects cerebellar granule cells, inducing pyroptosis and an aberrant proliferative state. Pyroptotic neuronal injury promotes microglial recruitment and activation, amplifying local neuroinflammation and ...
Tian‐Zhang Song, Li‐Rong Zhang, Yun‐Mei Wang, Yan Hu, Qing Li, Ren‐Rong Tian, Liu‐Meng Yang, Si‐Dong Xiong, Dong‐Dong Wu, Yong‐Tang Zheng   +9 more
wiley   +1 more source

Multiple Sclerosis and Viruses: « Liaisons Dangereuses »

Reviews in Medical Virology, Volume 36, Issue 6, November 2026.
ABSTRACT Multiple sclerosis (MS) is a complex, multifactorial neurodegenerative disease with an aetiology that is still partially elusive. Several risk factors are associated with MS development including genetic predisposition and various environmental stressors; however, recently, viral infections have gained significant attention as a crucial ...
Samanta Plavina, Daniela Malakovska, Jolanta Kalnina, Ilva Trapina, Elina Leonova, Mohammed Habib, Susanne Schifmann, Jegors Paramonovs, Nikolajs Sjakste, Yegor Vassetzky, Emmanuel Drouet, Natalia Paramonova   +11 more
wiley   +1 more source

Interleukin-2 is a potent latency reversal agent in people with treated HIV-1

Science Advances
Eliciting HIV-1 expression from latently infected CD4 + T cells allows these rare reservoir cells to become targets of the immune system and may also result in death of reservoir cells via virus-induced cytopathy.
Michael L. Freeman, Brian M. Clagett, Konstantin Leskov, Daniela Moisi, George A. Yendewa, Scott F. Sieg, Gregory M. Laird, Jonathan Karn, Jeffrey M. Jacobson, Benigno Rodriguez, Michael M. Lederman   +10 more
openaire   +3 more sources

THE ROLE OF VPR IN HIV-1 LATENCY [PDF]

Although antiretroviral therapy (ART) has dramatically improved the clinical prognosis for people with HIV and prevents transmission, ART is not a cure. This is because of a latent reservoir that persists in long-lived cells such as central memory CD4+ T
Lewis, Cat
core   +1 more source

Latency reversal agents modulate HIV antigen processing and presentation to CD8 T cells

, 2020
Latency reversal agents (LRA) variably induce HIV re-expression in CD4 T cells but reservoirs are not cleared. Whether HIV epitope presentation is similar between latency reversal and initial infection of CD4 T cells is unknown yet crucial to define ...
Jishnu Das (673243), Jishnu Das, Sylvie Le Gall, Neelambari Joshi, Neelambari Joshi (8605278), Julie Boucau (848832), Sylvie Le Gall (265951), Julie Boucau   +7 more
core   +1 more source