Results 101 to 110 of about 3,675 (177)

Immune endotypes in tuberculosis: Keys to decoding disease complexity

Journal of Internal Medicine, Volume 299, Issue 6, Page 670-693, June 2026.
Abstract Tuberculosis (TB) remains a major global health challenge, with multi‐drug antibiotic regimens as the current standard of care. While effective at killing Mycobacterium tuberculosis, these treatments do not resolve persistent inflammation, prevent lung damage, or reverse immune dysregulation that contribute to poor outcomes and disease ...
Shamila D. Alipoor, Julia Guthrie, Lina Davies Forsman, Andrew R. Di Nardo, Susanna Brighenti   +4 more
wiley   +1 more source

Croton oligandrus Pierre & Hutch (Euphorbiaceae) Extracts and Isolated Compounds Reverse HIV-1 Latency

Journal of Experimental Pharmacology
Chantal Emade Nkwelle,1,2 Smith B Babiaka,3,4 Clovis S Metuge,2,3 Kimberly Liang,5 Unique Stephens,5 Seraphine Nkie Esemu,1 David S Zuzga,5 Kristy Shuda McGuire,5 Luis J Montaner,5 Roland N Ndip,1 Ian Tietjen,5 Fidele Ntie-Kang2,3,6 1Department of ...
Emade Nkwelle C, Babiaka SB, Metuge CS, Liang K, Stephens U, Esemu SN, Zuzga DS, Shuda McGuire K, Montaner LJ, Ndip RN, Tietjen I, Ntie-Kang F   +11 more
doaj  

A novel HIV-1 latency reversing bromodomain inhibitor

, 2015
Trabajo presentado en la VII Spanish Drug Discovery Network Meeting, celebrada en Barcelona, España, del 12 al 13 de noviembre de ...
Jordan, Albert, Abner, Erik
openaire   +1 more source

Ethnopharmacological exploration and isolation of HIV-1 latency-reversing agents from Sudanese medicinal plants

Frontiers in Pharmacology
HIV-1 infection remains a major health challenge, especially in resource-limited settings such as Sudan, where traditional medicine is widely practiced for managing infectious diseases, including HIV/AIDS.
Khaled M. Elamin, Naoki Kishimoto, Naoki Kishimoto, Teppei Kawahara, Sara Mustafa Idris Elbashir, Tae Yasutake, Mikiyo Wada, Yuki Hitora, Maha Kordofani, Wadah Osman, Wadah Osman, Mustafa Idris Elbashir, Shogo Misumi, Shogo Misumi   +13 more
doaj   +1 more source

HIV-1 latency reversing agents converge on phosphoregulation of nuclear protein complexes

ABSTRACT Despite the success of antiretroviral therapy (ART), HIV-1 persists in latently infected cells, posing a central barrier to a cure. “Shock-and-kill” strategies using latency-reversing agents (LRAs) have shown some promise in reactivating viral gene expression ex vivo , but ...
Ni, Jocelyn J., Kaushal, Prashant, Sharma, Shipra, Makanani, Sara K., Delgado, Yennifer, Blanc, Sophie F., Olwal, Charles Ochieng, Ashley, Immy A., Winters, Declan M., Yang, Vivian, Phung, Callie N., Alba, Kareem, Wynn, Evan, Johnson, Jeffrey R., Hultquist, Judd F., Fregoso, Oliver I., Bouhaddou, Mehdi   +16 more
openaire   +2 more sources

Evaluation of HIV-1 latency reversal and antibody-dependent viral clearance by quantification of singly spliced HIV-1 vpu/env mRNA. [PDF]

J Virol, 2021
Gao H, Ozantürk AN, Wang Q, Harlan GH, Schmitz AJ, Presti RM, Deng K, Shan L.   +7 more
europepmc   +1 more source

Glucose-Fueled Histone Modifications Drive HIV-1 Latency Reversal at Hypoxia

Abstract The major barrier to curing HIV-1 infection is the persistence of a latent reservoir in CD4 T cells within tissues which readily fuel viral rebound upon antiretroviral therapy (ART) interruption. Clinical trials aimed at purging these viral reservoirs with latency reversal agents (LRAs) have been unsuccessful
Kayode, Yetunde I., Clemmer, Deanna C., Owolabi, Adebola A., AlShaheeb, AbdulKareem A., McMahon, Elyse K., Tangiyan, Anna, Clark, Lauren, Simmons, Glenn E., Bosque, Alberto, McReynolds, Melanie R., Taylor, Harry E.   +10 more
openaire   +2 more sources

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Reanalysis of Gene Expression Profiles of CD4+ T Cells Treated with HIV-1 Latency Reversal Agents. [PDF]

Microorganisms, 2020
Campos Coelho AV, Moura RR, Crovella S.
europepmc   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source