Results 101 to 110 of about 4,485 (189)

THE ROLE OF VPR IN HIV-1 LATENCY [PDF]

Although antiretroviral therapy (ART) has dramatically improved the clinical prognosis for people with HIV and prevents transmission, ART is not a cure. This is because of a latent reservoir that persists in long-lived cells such as central memory CD4+ T
Lewis, Cat
core   +2 more sources

Mathematical modeling and mechanisms of HIV latency for personalized anti latency therapies

npj Systems Biology and Applications
Combination antiretroviral therapy controls human immunodeficiency virus-1 (HIV) but cannot eradicate latent proviruses in immune cells, which reactivate upon treatment interruption.
Gianmarco Rasi, Elena Emili, Jessica M. Conway, Nicola Cotugno, Paolo Palma   +4 more
doaj   +1 more source

Machine Learning of Personal Repertoires From Public T Cell Receptors

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT The T‐cell receptor (TCR) repertoire records an individual's immunological history, but most unique CDR3 sequences in any one person are private and uninformative about anyone else. A small subset, however, recurs predictably across unrelated donors.
Or Malca, Alona Zilberberg, Sol Efroni
wiley   +1 more source

Long non-coding RNAs and latent HIV : a search for novel targets for latency reversal [PDF]

, 2019
The latent cellular reservoir of HIV is recognized as the major barrier to cure from HIV infection. Long non-coding RNAs (lncRNAs) are more tissue and cell type-specific than protein coding genes, and may represent targets of choice for HIV latency ...
Ward De Spiegelaere (116055), Christopher H Woelk, Steve Lefever (105018), Trypsteen, Wim, Bosque, Alberto, Beliakova-Bethell, Nadejda, Linos Vandekerckhove (105574), White, Cory H, Woelk, Christopher H, Nadejda Beliakova-Bethell (3367556), Cory H White, Alberto Bosque, Spina, Celsa A, Vicente Planelles, Christopher H. Woelk (195217), Planelles, Vicente, Linos Vandekerckhove, Wim Trypsteen (724114), Vicente Planelles (31768), Ward De Spiegelaere, Celsa A. Spina (7846787), Amey Mukim, Steve Lefever, Cory H. White (3367553), De Spiegelaere, Ward, Lefever, Steve, Mukim, Amey, Amey Mukim (5264588), Nadejda Beliakova-Bethell, Wim Trypsteen, Vandekerckhove, Linos, Celsa A Spina, Alberto Bosque (202328)   +32 more
core   +2 more sources

Corrigendum: Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency

Frontiers in Cellular and Infection Microbiology, 2023
Alexander O. Pasternak, Olivier Rohr, Olivier Rohr, Carine Van Lint, Anna Kula-Pacurar   +4 more
doaj   +1 more source

Latency Reversing Agents and the Road to an HIV Cure

Pathogens
HIV-1 infection cannot be cured due to the presence of HIV-1 latently infected cells. These cells do not produce the virus, but they can resume virus production at any time in the absence of antiretroviral therapy. Therefore, people living with HIV (PLWH)
Louis Tioka, Rafael Ceña Diez, Anders Sönnerborg, Maarten A. A. van de Klundert   +3 more
doaj   +1 more source

Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk.
Cynthiya Shrestha, Holly M. Weisfelder, Thanh D. Do   +2 more
wiley   +1 more source

Living Microbial Drugs

Chemistry – A European Journal, Volume 32, Issue 26, 11 July 2026.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

Neurotoxicity with high dose disulfiram and vorinostat used for HIV latency reversal [PDF]

, 2022
OBJECTIVE: To examine whether administering both vorinostat and disulfiram to people with HIV (PWH) on antiretroviral therapy (ART) is safe and can enhance HIV latency reversal.
Burger, D, Evans, VA, Heck, CJS, Lau, JSY, Zuck, P, Dantanarayana, A, Fisher, K, Rasmussen, TA, Wu, G, Zetterberg, HH, Lewin, SR, Tennakoon, S, Blennow, K, Hagenauer, M, Zerbato, JM, Mcmahon, JH, Howell, BJ, Gisslen, M, Palmer, S, Symons, J, Chang, J, Solomon, A, Lee, S, Bumpus, N   +23 more
core  

BRD9 functions as an HIV-1 latency regulatory factor [PDF]

A major challenge for HIV type 1 (HIV-1) cure is the presence of viral latent reservoirs. The “Shock & Kill” strategy involves the combined use of latency reversal agents (LRA) and antiretroviral treatment (ART) to reactivate HIV-1 latent reservoirs ...
Zhou, Runhong, Chen, Zhiwei, Huang, Huarong, Yim, Lok-Yan, Zhao, Meiqing, Lau, Thomas Tsz-Kan, Chan, Jasper Fuk-Woo, Cheng, Alfred Sze-Lok, Huang, Xiner, Yuen, Kwok-Yung, Chu, Hin, Dai, Jie, Luk, Tsz-Yat, Lui, Grace Chung-Yan, Mo, Yufei   +14 more
core   +1 more source