Results 121 to 130 of about 4,485 (189)

Ansellone J, a Potent in Vitro and ex Vivo HIV‑1 Latency Reversal Agent Isolated from a Phorbas sp. Marine Sponge [PDF]

Five new minor sesterterpenoids, ansellones H (4), I (5), J (6), and K (7) and phorone C (8), have been isolated from a Phorbas sp. marine sponge collected in British Columbia. Their structures have been elucidated by detailed analysis of NMR and MS data.
Raymond J. Andersen (155984), Silven Read (3915155), Karam Mounzer (5408), Amanda Sciorillo (12511258), Nicole de Voogd (12511273), David E. Williams (155960), Kwasi Gyampoh (12511264), Guorui Zu (12511267), Ian Tietjen (140813), Meng Wang (124646), Donya Naz Divsalar (12511261), Luis J. Montaner (12511270), Zhe Yuan (306523)   +12 more
core   +1 more source

Glucose-Fueled Histone Modifications Drive HIV-1 Latency Reversal at Hypoxia

Abstract The major barrier to curing HIV-1 infection is the persistence of a latent reservoir in CD4 T cells within tissues which readily fuel viral rebound upon antiretroviral therapy (ART) interruption. Clinical trials aimed at purging these viral reservoirs with latency reversal agents (LRAs) have been unsuccessful
Kayode, Yetunde I., Clemmer, Deanna C., Owolabi, Adebola A., AlShaheeb, AbdulKareem A., McMahon, Elyse K., Tangiyan, Anna, Clark, Lauren, Simmons, Glenn E., Bosque, Alberto, McReynolds, Melanie R., Taylor, Harry E.   +10 more
openaire   +2 more sources

Nuclear retention of unspliced HIV-1 RNA as a reversible post-transcriptional block in latency

Nature Communications
Abstract HIV-1 latency is mainly characterized at transcriptional level, and little is known about post-transcriptional mechanisms and their contribution to reactivation. The viral protein Rev controls the nucleocytoplasmic export of unspliced and singly-spliced RNA that is central to proviral replication-competence and is therefore a ...
Agnieszka Dorman, Maryam Bendoumou, Aurelija Valaitienė, Jakub Wadas, Haider Ali, Antoine Dutilleul, Paolo Maiuri, Lorena Nestola, Monika Bociaga-Jasik, Gilbert Mchantaf, Coca Necsoi, Stéphane De Wit, Véronique Avettand-Fenoël, Alessandro Marcello, Krzysztof Pyrc, Alexander O. Pasternak, Carine Van Lint, Anna Kula-Pacurar   +17 more
openaire   +7 more sources

Reanalysis of Gene Expression Profiles of CD4+ T Cells Treated with HIV-1 Latency Reversal Agents. [PDF]

Microorganisms, 2020
Campos Coelho AV, Moura RR, Crovella S.
europepmc   +1 more source

The African natural product knipholone anthrone and its analogue anthralin (dithranol) enhance HIV-1 latency reversal. [PDF]

J Biol Chem, 2020
Richard K, Schonhofer C, Giron LB, Rivera-Ortiz J, Read S, Kannan T, Kinloch NN, Shahid A, Feilcke R, Wappler S, Imming P, Harris M, Brumme ZL, Brockman MA, Mounzer K, Kossenkov AV, Abdel-Mohsen M, Andrae-Marobela K, Montaner LJ, Tietjen I.   +19 more
europepmc   +1 more source

24 Thalidomide reverses latency of HIV-1 provirus

Journal of Virus Eradication, 2016
S. Samer, T. Oshiro, T. Vergara, J. Gakinskas, S. Tenori, M.C. Sucupira, A. Duarte, R.S. Diaz   +7 more
openaire   +2 more sources

Integrated Assessment of Viral Transcription, Antigen Presentation, and CD8⁺ T Cell Function Reveals Multiple Limitations of Class I-Selective Histone Deacetylase Inhibitors during HIV-1 Latency Reversal. [PDF]

J Virol, 2020
Mota TM, McCann CD, Danesh A, Huang SH, Magat DB, Ren Y, Leyre L, Bui TD, Rohwetter TM, Kovacs CM, Benko E, MacLaren L, Wimpelberg A, Cannon CM, Hardy WD, Safrit JT, Jones RB.   +16 more
europepmc   +1 more source

Traditional Medicine Extracts of <i>Gnidia sericocephala</i> and Product Nkabinde in HIV-1 Latency Reversal: Insights from J-Lat Subtype B and J-Lat Subtype C Models. [PDF]

Int J Mol Sci
Mngomezulu K, Khathi SP, Nkabinde SA, Nkabinde M, Ngcobo M, Gqaleni N.   +5 more
europepmc   +1 more source

Optimisation of Smac mimetics as HIV-1 latency reversing agents

Journal of Virus Eradication, 2019
L. Pache, P. Teriete, M.D. Marsden, A.M. Spivak, D. Heimann, A.J. Portillo, V. Planelles, J.A. Zack, N.D.P. Cosford, S.K. Chanda   +9 more
openaire   +2 more sources

HIV-1 latency reversal and immune enhancing activity of IL-15 is not influenced by sex hormones. [PDF]

JCI Insight
Holmberg CS, Levinger C, Abongwa M, Ceriani C, Archin NM, Siegel M, Ghosh M, Bosque A.   +7 more
europepmc   +1 more source