Results 121 to 130 of about 29,994,236 (203)

BRD9 functions as an HIV-1 latency regulatory factor [PDF]

A major challenge for HIV type 1 (HIV-1) cure is the presence of viral latent reservoirs. The “Shock & Kill” strategy involves the combined use of latency reversal agents (LRA) and antiretroviral treatment (ART) to reactivate HIV-1 latent reservoirs ...
Zhou, Runhong, Chen, Zhiwei, Huang, Huarong, Yim, Lok-Yan, Zhao, Meiqing, Lau, Thomas Tsz-Kan, Chan, Jasper Fuk-Woo, Cheng, Alfred Sze-Lok, Huang, Xiner, Yuen, Kwok-Yung, Chu, Hin, Dai, Jie, Luk, Tsz-Yat, Lui, Grace Chung-Yan, Mo, Yufei   +14 more
core   +1 more source

UltRaSoUnd‐guided evaLuAtion of metabolic health in a cohort of midlife women with HIV: The URSULA study

HIV Medicine, Volume 27, Issue 10, Page 1650-1662, October 2026.
Abstract Objectives We aimed to determine the prevalence of metabolic disorders, liver steatosis and metabolic dysfunction‐associated steatotic liver disease (MASLD) in a cohort of middle‐aged women with HIV (WoWH) and to explore associations between liver steatosis, visceral fat depots and carotid atherosclerosis.
Mariacristina Poliseno, Davide Capruzzi, Antonio Cianciaruso, Nicola Colavito, Felicia Dalitto, Vincenzo Giliberti, Vittoria Lobalsamo, Giuliana Metrangolo, Marica Noviello, Alessandra Vigna, Maurizio Zarcone, Francesco Di Gennaro, Vincenzo Ostilio Palmieri, Annalisa Saracino   +13 more
wiley   +1 more source

Entering the Age of Specificity in T Cell Immunity

Immunological Reviews, Volume 343, Issue 1, October 2026.
ABSTRACT The discovery of MHC restriction, the resolution of peptide–MHC structure, and the identification of the T cell receptor gene quickly centered epitope‐level specificity as a core concern of T cell biology. Epitope mapping culminated in functional peptide‐based stimulation assays and tetramer staining, which together provide exquisite ...
Paul G. Thomas
wiley   +1 more source

Validation of Health Belief Model and Theory of Planned Behaviour Constructs for Predicting Malaria Vaccine Acceptance in Ghana: A Partial Least Squares Structural Equation Modelling Approach

Tropical Medicine &International Health, Volume 31, Issue 10, Page 1443-1452, October 2026.
ABSTRACT Aim This study examines the predictive power of constructs from the health belief model (HBM) and theory of planned behaviour (TPB) in explaining malaria vaccine acceptance in Ghana in the post‐COVID‐19 era, while also assessing the reliability of these constructs within this context.
Michael Sarfo, Michael Snowden, Jamie P. Halsall   +2 more
wiley   +1 more source

Metabolic Reprogramming during HIV latency reversal in pre-monocytic latent model

Despite advancements in antiviral therapy, HIV-1 remains a significant global health issue. The viral reservoirs are the main obstacle to identifying a functional cure.
Poznakovs, Sofja Sofia
core   +1 more source

The ENL-USP7 complex regulates HIV latency through BRD4 protein stabilization

Cell Reports
Summary: HIV persistence in CD4 + T cells and brain microglia is maintained by host mechanisms that enforce viral latency. We identify ENL and the deubiquitinase USP7 as a host complex that sustains HIV latency.
Waqas Ahmed, Xiaoyi Li, Ciniso S. Shabangu, Hongjie Chen, Nikesh Katuwal, Jennifer Kirchherr, Wenshe R. Liu, Xin Li, Yongcheng Song, Kaixiu Luo, H. Umit Kaniskan, Jian Jin, Sara Gianella, David M. Margolis, Nancie M. Archin, Yuyang Tang, Guochun Jiang   +16 more
doaj   +1 more source

Peptide‐Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales, Ana Clara Lunardi Yagi, Túlio Custódio Reis, Jessica Ingrid Cazorla, Jade Rojas Villar, Marcia A. Graminha, Roxana Yesenia Pastrana Alta, Fernando Rogério Pavan   +7 more
wiley   +1 more source

Ethnopharmacological exploration and isolation of HIV-1 latency-reversing agents from Sudanese medicinal plants

Frontiers in Pharmacology
HIV-1 infection remains a major health challenge, especially in resource-limited settings such as Sudan, where traditional medicine is widely practiced for managing infectious diseases, including HIV/AIDS.
Khaled M. Elamin, Naoki Kishimoto, Naoki Kishimoto, Teppei Kawahara, Sara Mustafa Idris Elbashir, Tae Yasutake, Mikiyo Wada, Yuki Hitora, Maha Kordofani, Wadah Osman, Wadah Osman, Mustafa Idris Elbashir, Shogo Misumi, Shogo Misumi   +13 more
doaj   +1 more source

Glucose-Fueled Histone Modifications Drive HIV-1 Latency Reversal at Hypoxia

Abstract The major barrier to curing HIV-1 infection is the persistence of a latent reservoir in CD4 T cells within tissues which readily fuel viral rebound upon antiretroviral therapy (ART) interruption. Clinical trials aimed at purging these viral reservoirs with latency reversal agents (LRAs) have been unsuccessful
Kayode, Yetunde I., Clemmer, Deanna C., Owolabi, Adebola A., AlShaheeb, AbdulKareem A., McMahon, Elyse K., Tangiyan, Anna, Clark, Lauren, Simmons, Glenn E., Bosque, Alberto, McReynolds, Melanie R., Taylor, Harry E.   +10 more
openaire   +2 more sources

Nuclear retention of unspliced HIV-1 RNA as a reversible post-transcriptional block in latency

Nature Communications
Abstract HIV-1 latency is mainly characterized at transcriptional level, and little is known about post-transcriptional mechanisms and their contribution to reactivation. The viral protein Rev controls the nucleocytoplasmic export of unspliced and singly-spliced RNA that is central to proviral replication-competence and is therefore a ...
Agnieszka Dorman, Maryam Bendoumou, Aurelija Valaitienė, Jakub Wadas, Haider Ali, Antoine Dutilleul, Paolo Maiuri, Lorena Nestola, Monika Bociaga-Jasik, Gilbert Mchantaf, Coca Necsoi, Stéphane De Wit, Véronique Avettand-Fenoël, Alessandro Marcello, Krzysztof Pyrc, Alexander O. Pasternak, Carine Van Lint, Anna Kula-Pacurar   +17 more
openaire   +7 more sources