Results 81 to 90 of about 29,994,236 (203)
Cell Reports Medicine, 2020 Summary: “Shock and kill” strategies focus on purging the latent HIV-1 reservoir by treating infected individuals with therapeutics that activate the latent virus and subsequently eliminating infected cells.
Lars Pache +14 more
doaj +1 more source
Sickle Cell Disease: Historical Overview and Current Therapies
Prenatal Diagnosis, EarlyView.ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde +4 more
wiley +1 more source
JCI Insight, 2023 IL-15 is under clinical investigation toward the goal of curing HIV infection because of its abilities to reverse HIV latency and enhance immune effector function. However, increased potency through combination with other agents may be needed.
Dennis C. Copertino Jr. +23 more
doaj +1 more source
HIV-1 has a sweet tooth: glucose metabolism drives the multistep process of HIV-1 latency reversal [PDF]
The major barrier to a cure for HIV-1 is the establishment of latency in long-lived CD4+ T cells within lymphoid tissues which readily fuel viral rebound upon antiretroviral therapy (ART) interruption.
Kayode, Yetunde
core
Using a CRISPR-based screen to study individual and combination molecular mechanisms of HIV-1 latency [PDF]
, 2022 Thesis (Ph.D.)--University of Washington, 2022Long-lived immune cells harboring transcriptionally silenced, latent Human Immunodeficiency Virus Type 1 (HIV-1) proviruses continues to pose a barrier to HIV-1 cure.
Hsieh, Emily
core
Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux +6 more
wiley +1 more source
Concurrent sexual partnerships and HIV prevalence in five urban communities of sub-Saharan Africa. [PDF]
, 2001 OBJECTIVE: To estimate parameters of concurrent sexual partnerships in five urban populations in sub-Saharan Africa and to assess their association with levels of HIV infection and other sexually transmitted infections (STI).
Lagarde, E. +24 more
core +1 more source
The Mitigating Role of Managerial Ability in ESG Decoupling
Sustainable Development, EarlyView.ABSTRACT Does managerial competence widen or bridge the gap between environmental, social, and governance (ESG) disclosures and actual performance? This paper explores the relationship between CEO ability and corporate decoupling regarding sustainability issues.
Isabel‐María García‐Sánchez +3 more
wiley +1 more source
Smart Molecules, EarlyView.AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin +10 more
wiley +1 more source
Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo
JCI Insight, 2023 TGF-β plays a critical role in maintaining immune cells in a resting state by inhibiting cell activation and proliferation. Resting HIV-1 target cells represent the main cellular reservoir after long-term antiretroviral therapy (ART).
Sadia Samer +24 more
doaj +1 more source