Results 81 to 90 of about 4,485 (189)

Identification of novel cellular factors involved in HIV-1 latency [PDF]

, 2020
Despite ongoing efforts, HIV-1 (the causative agent of AIDS) remains an unresolved health threat. Even though current therapy approaches efficiently block ongoing viral replication they cannot cure the infection due to the presence of a latent reservoir.
Borch, Alexandra
core   +1 more source

Distinct chromatin functional states correlate with HIV latency reactivation in infected primary CD4+ T cells

eLife, 2018
Human immunodeficiency virus (HIV) infection is currently incurable, due to the persistence of latently infected cells. The ‘shock and kill’ approach to a cure proposes to eliminate this reservoir via transcriptional activation of latent proviruses ...
Emilie Battivelli, Matthew S Dahabieh, Mohamed Abdel-Mohsen, J Peter Svensson, Israel Tojal Da Silva, Lillian B Cohn, Andrea Gramatica, Steven Deeks, Warner C Greene, Satish K Pillai, Eric Verdin   +10 more
doaj   +1 more source

Pharmacological Activation of Non-canonical NF-κB Signaling Activates Latent HIV-1 Reservoirs In Vivo

Cell Reports Medicine, 2020
Summary: “Shock and kill” strategies focus on purging the latent HIV-1 reservoir by treating infected individuals with therapeutics that activate the latent virus and subsequently eliminating infected cells.
Lars Pache, Matthew D. Marsden, Peter Teriete, Alex J. Portillo, Dominik Heimann, Jocelyn T. Kim, Mohamed S.A. Soliman, Melanie Dimapasoc, Camille Carmona, Maria Celeridad, Adam M. Spivak, Vicente Planelles, Nicholas D.P. Cosford, Jerome A. Zack, Sumit K. Chanda   +14 more
doaj   +1 more source

Validation of an UHPLC–MS/MS Assay for the Quantification of Isoniazid and Four Major Metabolites in Human Plasma

Biomedical Chromatography, Volume 40, Issue 9, September 2026.
ABSTRACT Isoniazid (INH) is a key component of tuberculosis treatment regimens but is also associated with hepatotoxicity. This toxicity is mediated in part by its metabolites, but some degrade rapidly in plasma. A rapid freeze/thaw process with a methanol protein precipitation extraction was developed to slow the rapid degradation of acetylisoniazid ...
David Nerguizian, Brandon Klein, Farah Abdelmawla, Joe Gomez, Peter L. Anderson, Lane Bushman, Kristina M. Brooks   +6 more
wiley   +1 more source

Coloring hidden viruses

eLife, 2018
An improved dual-color reporter reveals how the fate of latent HIV-1 depends on where it integrates in the human genome.
Marina Lusic
doaj   +1 more source

Delineating gender/sex‐related studies through bibliometric analysis

Journal of the Association for Information Science and Technology, Volume 77, Issue 8, Page 1015-1031, August 2026.
Abstract The multidisciplinary and socially grounded nature of Women's/Gender/Feminist Studies poses unique challenges for bibliometric analysis, as it extends beyond conventional disciplinary boundaries. This paper makes three key contributions: (1) We propose a novel retrieval method for constructing a corpus of scholarly documents in research areas ...
Natsumi S. Shokida, Diego Kozlowski, Vincent Larivière   +2 more
wiley   +1 more source

The latency-reversing agent HODHBt synergizes with IL-15 to enhance cytotoxic function of HIV-specific T cells

JCI Insight, 2023
IL-15 is under clinical investigation toward the goal of curing HIV infection because of its abilities to reverse HIV latency and enhance immune effector function. However, increased potency through combination with other agents may be needed.
Dennis C. Copertino Jr., Carissa S. Holmberg, Jared Weiler, Adam R. Ward, J. Natalie Howard, Callie Levinger, Alina P.S. Pang, Michael J. Corley, Friederike Dündar, Paul Zumbo, Doron Betel, Rajesh T. Gandhi, Deborah K. McMahon, Ronald J. Bosch, Noemi Linden, Bernard J. Macatangay, Joshua C. Cyktor, Joseph J. Eron, John W. Mellors, Colin Kovacs, Erika Benko, Alberto Bosque, R. Brad Jones, for the AIDS Clinical Trials Group (ACTG) A5321 Team   +23 more
doaj   +1 more source

Design, Synthesis, and Biological Evaluation of Chiral Urea and Thiourea Derivatives as Multitarget‐Directed Anti‐Alzheimer Agents

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A series of novel chiral urea and thiourea compounds were designed as multitarget‐directed ligands for Alzheimer's disease and evaluated against hAChE, hBChE, and hMAO‐B, with exploratory assessment of HSD10. These chiral compounds were synthesized and fully characterized, and their enantiopurity was confirmed via HPLC.
Sule Erol Gunal, Senel Teke Tuncel, İlke Demir, İpek Baysal, Gökçen Telli, Safiye Sag Erdem, Gulberk Ucar, Michaela Hanzlova, Kamil Musilek, İlknur Dogan, Nesrin Gokhan Kelekci   +10 more
wiley   +1 more source

Strong‐Ties and Weak‐Ties Rationalities: Predicting Public Stigma, Support Networks, and Health Behaviours During the COVID‐19 Pandemic Across Four Societies

International Journal of Psychology, Volume 61, Issue 4, August 2026.
ABSTRACT In this study, we test the theory of strong‐ties and weak‐ties rationalities (STWTR) (Sundararajan 2020) and the criterion validity of its measures using strong‐ties rationality and weak‐ties rationality scales to predict COVID‐19 related perceptions and behaviours.
Rachel Sing‐Kiat Ting, Jane Terpstra‐Tong, May Kyi Zay Hta, Zhong‐Yao Xie, Yi‐Fan Chen, Michael Harris Bond, Kuang‐Hui Yeh, Louise Sundararajan   +7 more
wiley   +1 more source

HIV-1 has a sweet tooth: glucose metabolism drives the multistep process of HIV-1 latency reversal [PDF]

The major barrier to a cure for HIV-1 is the establishment of latency in long-lived CD4+ T cells within lymphoid tissues which readily fuel viral rebound upon antiretroviral therapy (ART) interruption.
Kayode, Yetunde
core