Results 151 to 160 of about 30,666,235 (182)
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The role of the viral glycoprotein in HIV-1 persistence
Immunology Letters, 1999The study of the immunological defects which arise from HIV infection has led to a deeper understanding both of the normal immune system and of the mechanisms by which it is damaged in disease. The interactions between viral and host factors during the early stages of HIV infection leads to a post-seroconversion steady state or 'set point' of viral RNA
J A, McKeating, P, Balfe
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Current views on HIV-1 latency, persistence, and cure
Folia Microbiologica, 2016HIV-1 infection cannot be cured as it persists in latently infected cells that are targeted neither by the immune system nor by available therapeutic approaches. Consequently, a lifelong therapy suppressing only the actively replicating virus is necessary.
Zora, Melkova +3 more
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CNS Persistence of HIV-1 in Children: the Untapped Reservoir
Current HIV/AIDS Reports, 2018The central nervous system (CNS) represents a potential HIV-1 reservoir that may need to be specifically targeted by remission strategies. Perinatally HIV-1-infected children and youth are exposed to HIV-1 at a critical period of brain development. This review summarizes the current literature regarding HIV-1 and the CNS in perinatal infection.HIV-1 ...
Ann, Chahroudi +2 more
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HIV-1 Reservoir Persistence and Decay: Implications for Cure Strategies
Current HIV/AIDS Reports, 2022Despite suppressive antiretroviral therapy (ART), a viral reservoir persists in individuals living with HIV that can reignite systemic replication should treatment be interrupted. Understanding how HIV-1 persists through effective ART is essential to develop cure strategies to induce ART-free virus remission.The HIV-1 reservoir resides in a pool of CD4-
Edward F. Kreider, Katharine J. Bar
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Unraveling the root causes of HIV-1 persistence
Current Opinion in HIV and AIDSPurpose of review Although ART suppresses HIV-1 viral loads to undetectable levels and frequently enables a near-normal life expectancy for persons living with HIV, a reservoir of infected cells persists lifelong and cannot be eliminated with currently available therapeutic strategies.
Weiwei, Sun, Mathias, Lichterfeld
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Follicular T helper cells: hotspots for HIV-1 persistence
Nature Medicine, 2016Reservoirs of virally infected cells that are resistant to standard antiretroviral therapy make HIV-1 infection an incurable disease. A new study shows that follicular T helper cells in lymph node germinal centers are prime niches for HIV-1 persistence during antiviral therapy.
Mirko, Paiardini, Mathias, Lichterfeld
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Integration Sites in the Persistence of Latent HIV-1
2022A thesis presented to the faculty of The Rockefeller University in partial fulfillment of the requirements for the degree of Doctor of ...
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Extrachromosomal HIV-1 DNA in Persistently Infected U937 Cells
AIDS Research and Human Retroviruses, 1990Persistent human immunodeficiency virus type 1 (HIV-1) infection of U937 monocytic cells resulted in the accumulation of novel forms of extrachromosomal viral DNA. These DNA species are larger than the genome size of HIV-1 and persist indefinitely. The extrachromosomal viral DNA species (E-DNA) were shown to be structurally stable by subcloning of ...
C D, Pauza, M K, Singh
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HIV-1 Myeloid Reservoirs — Contributors to Viral Persistence and Pathogenesis
Current HIV/AIDS ReportsHIV reservoirs are the main barrier to cure. CD4+ T cells have been extensively studied as the primary HIV-1 reservoir. However, there is substantial evidence that HIV-1-infected myeloid cells (monocytes/macrophages) also contribute to viral persistence and pathogenesis.Recent studies in animal models and people with HIV-1 demonstrate that myeloid ...
Edna A, Ferreira +2 more
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Persistent inapparent HIV-1 infection of human neuroblastoma cells
Archives of Virology, 1991We have studied human immunodeficiency virus type 1 (HIV-1) infection in three different human neuroblastoma cell lines; SK-N-MC, IMR-32 and SH-SY5Y. In all of these cell lines the infection became productive. However, the virus expression was different as determined by the p24 antigen capture assays from culture supernatants and immunochemical (APAAP)
M, Vesanen, T, Linna, A, Vaheri
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