Results 71 to 80 of about 54,634 (147)

CD8 lymphocytes mitigate HIV-1 persistence in lymph node follicular helper T cells during hyperacute-treated infection. [PDF]

Nat Commun, 2022
Baiyegunhi OO, Mann J, Khaba T, Nkosi T, Mbatha A, Ogunshola F, Chasara C, Ismail N, Ngubane T, Jajbhay I, Pansegrouw J, Dong KL, Walker BD, Ndung'u T, Ndhlovu ZM.   +14 more
europepmc   +1 more source

HIV-1 persistence in the CNS: Mechanisms of latency, pathogenesis and an update on eradication strategies. [PDF]

Virus Res, 2021
Sonti S, Sharma AL, Tyagi M.
europepmc   +1 more source

Early pandemic HIV-1 integration site preferences differ across anatomical sites

Communications Medicine
Background HIV-1 persists in the body even when treatment suppresses viral replication. This persistence is due in part to the virus integrating into the DNA of infected cells.
Hinissan P. Kohio, Hannah O. Ajoge, Emile A. Barua, Neel R. Vajaria, Isaac K. F. Wu, Macon D. Coleman, Sean K. Tom, Frank van der Meer, John Gill, Deirdre Church, Paul Beck, Christopher Power, Guido van Marle, Stephen D. Barr   +13 more
doaj   +1 more source

Uncovering the impact of randomness in HIV hotspot formation: A mathematical modeling study.

PLoS Computational Biology
BackgroundHIV hotspots, regions with higher prevalence than surrounding areas, are observed across Africa, yet their formation and persistence mechanisms remain poorly understood.
Nao Yamamoto, Daniel T Citron, Samuel M Mwalili, Duncan K Gathungu, Diego F Cuadros, Anna Bershteyn   +5 more
doaj   +1 more source

The Clonal Expansion Dynamics of the HIV-1 Reservoir: Mechanisms of Integration Site-Dependent Proliferation and HIV-1 Persistence. [PDF]

Viruses, 2021
Yeh YJ, Yang K, Razmi A, Ho YC.
europepmc   +1 more source

Tracking HIV persistence across T cell lineages during early ART-treated HIV-1-infection using a reservoir-marking humanized mouse model

Nature Communications
Human immunodeficiency virus (HIV) infection depletes CD4 T-cells, and long-term persistence of latent virus prevents full clearance of HIV even in the presence of effective antiretroviral therapy (ART), Here we present the HIV-1-induced lineage tracing (
Namita Satija, Foramben Patel, Gerrit Schmidt, Donald V. Doanman, Manav Kapoor, Annalena La Porte, Ying-Chih Wang, Kenneth M. Law, Anthony M. Esposito, Kimaada Allette, Kristin G. Beaumont, Robert P. Sebra, Benjamin K. Chen   +12 more
doaj   +1 more source

Autologous HIV-specific T cell therapy targeting conserved epitopes is well-tolerated in six adults with HIV: an open-label, single-arm phase 1 study

Nature Communications
Novel cellular therapies may enable HIV control or cure. HIV-specific T cells targeting conserved immunogenic protein regions of HIV Gag/Pol and the entirety of HIV Nef, termed HST-NEETs, eliminate HIV infected cells in vitro.
Danielle K. Sohai, Michael D. Keller, Patrick J. Hanley, Fahmida Hoq, Divyesh Kukadiya, Anushree Datar, Emily Reynolds, Dennis C. Copertino, Christopher Lazarski, Chase D. McCann, Jay Tanna, Abeer Shibli, Haili Lang, Anqing Zhang, Pamela A. Chansky, Cecilia Motta, Tan T. Huynh, Bridget Dwyer, Andrew Wilson, Rebecca Lynch, Talia M. Mota, Winiffer D. Conce Alberto, Zabrina L. Brumme, Natalie N. Kinloch, Conrad Russell Y. Cruz, Lynsay MacLaren Ehui, Sarah Henn, R. Brad Jones, Catherine M. Bollard   +28 more
doaj   +1 more source

HIV-1 persistence during ART [PDF]

, 2016
openaire   +1 more source

HIV-1 Persistence and Chronic Induction of Innate Immune Responses in Macrophages. [PDF]

Viruses, 2020
Akiyama H, Gummuluru S.
europepmc   +1 more source

Transcription factor BACH2 shapes tissue-resident memory T cell programs to promote HIV-1 persistence. [PDF]

Immunity
Wei Y, Ma HK, Wong ME, Back H, Papasavvas E, Mounzer K, Aberra F, Morgenstern R, Tebas P, Konnikova L, Montaner LJ, Ho YC.   +11 more
europepmc   +1 more source