Results 111 to 120 of about 36,030 (253)

Lewis‐X‐Containing Triterpenoid Saponins Inhibit DC‐SIGN‐ and L‐SIGN‐Mediated Transfer of HIV‐1 Infection

Chemistry – A European Journal, Volume 31, Issue 32, June 6, 2025.
The convergent synthesis of Lewis‐X‐containing betulinic acid and echinocystic acid saponins (1 and 2) is presented. The synthetic saponins were shown to inhibit, at the low micromolar range, the DC‐SIGN‐ and L‐SIGN‐mediated transfer of HIV‐1 infection to CD4‐positive cells, whereas free Lewis‐X, aglycones, and structurally similar triterpenoid ...
Oscar Javier Gamboa Marin, Kurtis Ng, Nitish Verma, Assi Gérard Flavien Yapi, Ralph Pantophlet, Charles Gauthier   +5 more
wiley   +1 more source

Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design [PDF]

, 2014
Includes bibliographical references.Inducing broadly neutralizing antibodies targeting the HIV-1 envelope is thought to be crucial for developing an effective vaccine.
Jacob, Rajesh Abraham
core  

Envelope-receptor interactions in Nipah virus pathobiology. [PDF]

, 2007
Nipah (NiV) and Hendra (HeV) viruses are members of the newly defined Henipavirus genus of the Paramyxoviridae. Nipah virus (NiV) is an emergent paramyxovirus that causes fatal encephalitis in up to 70% of infected patients, and there is increasing ...
Lee, Benhur
core   +1 more source

Generation and Characterization of a Bivalent HIV-1 Subtype C gp120 Protein Boost for Proof-of-Concept HIV Vaccine Efficacy Trials in Southern Africa.

PLoS ONE, 2016
The viral envelope glycoprotein (Env) is the major target for antibody (Ab)-mediated vaccine development against the Human Immunodeficiency Virus type 1 (HIV-1).
Carlo Zambonelli, Antu K Dey, Susan Hilt, Samuel Stephenson, Eden P Go, Daniel F Clark, Mark Wininger, Celia Labranche, David Montefiori, Hua-Xin Liao, Ronald I Swanstrom, Heather Desaire, Barton F Haynes, Andrea Carfi, Susan W Barnett   +14 more
doaj   +1 more source

Discrete partitioning of HIV-1 Env forms revealed by viral capture [PDF]

, 2015
BACKGROUND: The structure of HIV-1 envelope glycoprotein (Env) is flexible and heterogeneous on whole virions. Although functional Env complexes are thought to require trimerization of cleaved gp41/gp120 heterodimers, variable processing can result in ...
Aldon, Y, King, DF, Klein, K, Mckay, PF, Shattock, RJ, Stieh, DJ   +5 more
core   +3 more sources

Detection of antibody-dependent complement mediated inactivation of both autologous and heterologous virus in primary HIV-1 infection [PDF]

, 2005
Specific CD8 T-cell responses to human immunodeficiency virus type 1 (HIV-1) are induced in primary infection and make an important contribution to the control of early viral replication.
Aasa-Chapman, M.M.I., Aubin, K., Borrow, P., Cornforth, D., Holuigue, S., Jones, N.A., McKnight, A., Newton, P., Pellegrino, P., Williams, I., Wong, M.   +10 more
core  

Heterologous prime-boost-boost immunisation of Chinese cynomolgus macaques using DNA and recombinant poxvirus vectors expressing HIV-1 virus-like particles [PDF]

, 2011
Background: There is renewed interest in the development of poxvirus vector-based HIV vaccines due to the protective effect observed with repeated recombinant canarypox priming with gp120 boosting in the recent Thai placebo-controlled trial.
Anson, Donald S., Blanchard, Thomas, Blanchard, Tom J., Bridge, Simon H., Dennis, Mike J., Dowall, Stuart D., Getty, Brian, Sharpe, Sally A., Skinner, Michael A., Stewart, James P.   +9 more
core   +4 more sources

Glycoform Analysis of Recombinant and Human Immunodeficiency Virus Envelope Protein gp120 via Higher Energy Collisional Dissociation and Spectral-Aligning Strategy

Analytical Chemistry, 2014
Envelope protein gp120 of human immunodeficiency virus (HIV) is armored with a dense glycan shield, which plays critical roles in envelope folding, immune-evasion, infectivity, and immunogenicity.
Weiming Yang, Punit Shah, S. Eshghi, Shuang Yang, Shisheng Sun, Minghui Ao, A. Rubin, J. B. Jackson, J. B. Jackson, Hui Zhang   +9 more
semanticscholar   +1 more source

Immunogenicity and protection mediated by dmLT and alum adjuvants for an HIV-1 vaccine

Frontiers in Immunology
The development of an effective HIV-1 vaccine is of paramount importance to global health. Here, we compared the influence of two adjuvants, Escherichia coli double-mutant heat-labile toxin (dmLT) and alum, on the protective immunity induced by a ...
Kasey Stokdyk, Kasey Stokdyk, Anusmita Sahoo, Anusmita Sahoo, Sailaja Gangadhara, Sailaja Gangadhara, LaTonya D. Williams, LaTonya D. Williams, Tiffany M. Styles, Tiffany M. Styles, Caleb A. Hellman, Caleb A. Hellman, Lu Zhang, Lu Zhang, Ahmad J. Odeh, Ahmad J. Odeh, Shelby Flaherty, Xiaoying Shen, Mohammad Arif Rahman, Elizabeth B. Norton, Genoveffa Franchini, David Montefiori, Pamela A. Kozlowski, Georgia D. Tomaras, Georgia D. Tomaras, Rama Rao Amara, Rama Rao Amara   +26 more
doaj   +1 more source

Reversal of Cognitive Impairment in gp120 Transgenic Mice by the Removal of the p75 Neurotrophin Receptor

Frontiers in Cellular Neuroscience, 2019
Activation of the p75 neurotrophin receptor (p75NTR), by the proneurotrophin brain-derived neurotrophic factor (proBDNF), triggers loss of synapses and promotes neuronal death.
Andrew Speidell, Gino Paolo Asuni, Valeria Avdoshina, Serena Scognamiglio, Patrick Forcelli, Italo Mocchetti   +5 more
doaj   +1 more source