Results 11 to 20 of about 36,030 (253)
Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120 [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance Significant heterogeneity exists in the structure and antigenicity of HIV-1 envelope protein (Env) gp120 due, in part, to various posttranslational modifications. Using glycan and antigenic analysis, we show that the signal peptide (SP) of HIV Env can impact the glycan profile of gp120, which in turn impacts antigenicity of the ...
Yolitz, Jason +8 more
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M‐tropic HIV envelope protein gp120 exhibits a different neuropathological profile than T‐tropic gp120 in rat striatum [PDF]
European Journal of Neuroscience, 2010 AbstractMost early human immunodeficiency virus type 1 (HIV‐1) strains are macrophage (M)‐tropic HIV variants and use the chemokine receptor CCR5 for infection. Neuronal loss and dementia are less severe among individuals infected with M‐tropic strains.
Alessia, Bachis +2 more
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Journal of General Virology, 2005 The envelope protein (gp120) of human immunodeficiency virus (HIV) contains highly conserved mannosylated oligosaccharides. These glycoconjugates contribute to resistance to antibody neutralization, and binding to cell surface lectins on macrophages and dendritic cells. Mannose-binding lectin (MBL) binds to gp120 and plays a role in defence against the
Meschi, Joseph +9 more
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Learning impairment following intracerebral administration of the HIV envelope protein gp120 or a VIP antagonist [PDF]
Brain Research, 1992 The external envelope glycoprotein (gp120) of the human immunodeficiency virus (HIV) has been shown to be toxic to neurons in culture. To further investigate the neurological effects of gp120, the involvement of this protein with the acquisition of spatial discrimination was assessed.
J R, Glowa +5 more
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HIV-1 Envelope Protein gp120 Promotes Proliferation and the Activation of Glycolysis in Glioma Cell [PDF]
Cancers, 2018 Patients infected with human immunodeficiency virus (HIV) are more prone to developing cancers, including glioblastomas (GBMs). The median survival for HIV positive GBM patients is significantly shorter than for those who are uninfected, despite the fact that they receive the same treatments.
Gabriel Valentín-Guillama +11 more
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Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.
The Journal of Immunology, 1988 Abstract The CD4 molecule is functionally involved in the class II MHC-restricted T cell response to Ag. CD4 is also the receptor for HIV-1, the major etiologic agent of AIDS. We have assessed whether the interaction of the HIV-1 envelope protein with the CD4 molecule might interfere with the normal function of CD4, thereby contributing ...
D C, Diamond +5 more
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Amelioration of Neurotoxic Effects of HIV Envelope Protein gp120 by Fibroblast Growth Factor: A Strategy for Neuroprotection [PDF]
Journal of Neuropathology & Experimental Neurology, 2001 Approximately two thirds of patients with human immunodeficiency virus encephalitis (HIVE) show cognitive impairment and neurodegeneration, while one third are cognitively unimpaired and their neuronal populations are preserved. Thus, it is possible that these individuals might have the capacity to produce neurotrophic factors capable of protecting ...
Everall, I P +5 more
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Positive In Vivo Selection of the HIV‐1 Envelope Protein gp120 Occurs at Surface‐Exposed Regions [PDF]
The Journal of Infectious Diseases, 2007 The rapid evolution of human immunodeficiency virus (HIV) envelope represents a major challenge to vaccine and drug development, particularly because the underlying mechanisms are not completely understood. To explore whether distinct patterns of positive selection within the envelope glycoprotein (gp) 120 exist and are associated with functionally ...
Joos, B +8 more
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HIV‐1 Envelope Protein gp120 Is Present at High Concentrations in Secondary Lymphoid Organs of Individuals with Chronic HIV‐1 Infection [PDF]
The Journal of Infectious Diseases, 2009 The envelope protein of human immunodeficiency virus type 1 (HIV-1)--glycoprotein 120 (gp120)--has been demonstrated to dysregulate T cell function in vitro. We obtained autopsy tissues from individuals with chronic HIV-1 infection to determine whether there was enough gp120 in lymphoid tissues and/or blood to elicit these effects.
Santosuosso M +4 more
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