Results 21 to 30 of about 36,030 (253)

The HIV-1 envelope protein gp120 is captured and displayed for B cell recognition by SIGN-R1+ lymph node macrophages

eLife, 2015
The HIV-1 envelope protein gp120 is both the target of neutralizing antibodies and a major focus of vaccine efforts; however how it is delivered to B cells to elicit an antibody response is unknown.
Chung Park, James Arthos, Claudia Cicala, John H Kehrl   +3 more
doaj   +2 more sources

Mechanism of Anti-HIV Activity of Negatively Charged Albumins: Biomolecular Interaction with the HIV-1 Envelope Protein gp120

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 1996
A novel class of polyanionic proteins with potent anti-human immunodeficiency virus type 1 activity, the negatively charged albumins (NCAs), have been reported previously. In vitro antiviral assays established that these compounds preferentially inhibit virus-cell fusion and syncytium formation and that virus-cell binding is less affected.
Kuipers, M. E., Huisman, J. G., Swart, P. J., de Béthune, M. P., Pauwels, R., Schuitemaker, H., de Clercq, E., Meijer, D. K.   +7 more
openaire   +5 more sources

Dual-acting stapled peptides target both HIV-1 entry and assembly [PDF]

, 2013
Background: Previously, we reported the conversion of the 12-mer linear and cell-impermeable peptide CAI to a cell-penetrating peptide NYAD-1 by using an i,i + 4 hydrocarbon stapling technique and confirmed its binding to the C-terminal domain (CTD ...
Bhargava, P., Cooper, A., Curreli, F., Debnath, A.K., Freed, E.O., Lee, S., Mehta, M., Mercredi, P.Y., Scacalossi, D., Summers, M.F., Tong, X., Waheed, A.A., Zhang, H.   +12 more
core   +2 more sources

Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding [PDF]

, 2016
The surface envelope glycoprotein (SU) of Human immunodeficiency virus type 1 (HIV-1), gp120SU plays an essential role in virus binding to target CD4+ T-cells and is a major vaccine target.
Bess, JW, Binet, D, Bouché, L, Canis, K, Chertova, E, Dell, A, Desrosiers, RC, Haslam, SM, Keele, BF, Lifson, JD, Morris, HR, North, SJ, O'Connor, MJ, Pang, PC, Panico, M, Rahman, D   +15 more
core   +1 more source

Novel peptides based on HIV-1 gp120 sequence with homology to chemokines inhibit HIV infection in cell culture.

PLoS ONE, 2011
The sequential interaction of the envelope glycoprotein of the human immunodeficiency virus type 1 (HIV-1) with CD4 and certain chemokine coreceptors initiates host cell entry of the virus.
Oleg Chertov, Ning Zhang, Xin Chen, Joost J Oppenheim, Jacek Lubkowski, Connor McGrath, Raymond C Sowder, Bruce J Crise, Anatoli Malyguine, Michele A Kutzler, Amber D Steele, Earl E Henderson, Thomas J Rogers   +12 more
doaj   +1 more source

Anti-HIV-1 activity of cellulose acetate phthalate: Synergy with soluble CD4 and induction of "dead-end" gp41 six-helix bundles [PDF]

, 2002
BACKGROUND: Cellulose acetate phthalate (CAP), a promising candidate microbicide for prevention of sexual transmission of the human immunodeficiency virus type 1 (HIV-1) and other sexually transmitted disease (STD) pathogens, was shown to inactivate HIV ...
A Nicholls, A Robert Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AS Dimitrov, Asim K Debnath, CE Parker, CH Chen, CM Carr, CM Carr, DC Chan, DC Chan, DL LeDuc, DR Littman, E de Rosny, EG Cormier, EG Cormier, GB Melikyan, H Deng, I Munoz-Barroso, J Bentz, J Chen, JA McKeating, JJ Skehel, K Tan, KH Manson, M Farzan, M Lu, M Thali, MK Gorny, Nathan Strick, P Lusso, PD Kwong, PL Jones, QJ Sattentau, QJ Sattentau, QJ Sattentau, R Wyatt, R Wyatt, RA Furuta, RL Willey, RW Doms, S Gartner, S Jiang, S Jiang, SA Gallo, Shibo Jiang, SL Orloff, SP Layne, T Gyotoku, T Kawamura, T Korte, T Weber, T-C Chou, TN Hart, U Moebius, VA Johnson, W Weissenhorn, W Weissenhorn, X-Z Pan, Y Kliger, Yun-Yao Li   +67 more
core   +3 more sources

Rescue of adult hippocampal neurogenesis in a mouse model of HIV neurologic disease

Neurobiology of Disease, 2011
The prevalence of central nervous system (CNS) neurologic dysfunction associated with human immunodeficiency virus (HIV) infection continues to increase, despite the use of antiretroviral therapy.
Myoung-Hwa Lee, Tongguang Wang, Mi-Hyeon Jang, Joseph Steiner, Norman Haughey, Guo-li Ming, Hongjun Song, Avindra Nath, Arun Venkatesan   +8 more
doaj   +1 more source

Surfactant protein D inhibits HIV-1 infection of target cells via interference with gp120-CD4 interaction and modulates pro-inflammatory cytokine production [PDF]

, 2014
© 2014 Pandit et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Al-Mozaini, MA, Gajbhiye, R, Gopal, S, Idicula-Thomas, S, Kishore, U, Kulkarni, V, Madan, T, Pandit, H, Patil, A, Qaseem, AS, Sonawani, A, Warke, H, Yadav, AK   +12 more
core   +3 more sources

Effect of naringin on gp120-induced injury mediated by P2X7 receptors in rat primary cultured microglia. [PDF]

PLoS ONE, 2017
Human immunodeficiency virus type-1 (HIV-1) envelope glycoprotein 120 has been shown to activate microglia, causing release of inflammatory and toxic factors.
Qiang Chen, Hui Wu, Jia Tao, Chenglong Liu, Zeyu Deng, Yang Liu, Guoqiao Chen, Baoyun Liu, Changshui Xu   +8 more
doaj   +1 more source

Binding of HIV-1 gp120 to DC-SIGN promotes ASK-1-dependent activation-induced apoptosis of human dendritic cells.

PLoS Pathogens, 2013
During disease progression to AIDS, HIV-1 infected individuals become increasingly immunosuppressed and susceptible to opportunistic infections. It has also been demonstrated that multiple subsets of dendritic cells (DC), including DC-SIGN⁺ cells, become
Yongxiong Chen, Shiuh-Lin Hwang, Vera S F Chan, Nancy P Y Chung, Shu-Rong Wang, Zhongye Li, Jing Ma, Chia-Wei Lin, Ya-Ju Hsieh, Kao-Ping Chang, Sui-Sum Kung, Yi-Chia Wu, Cheng-Wei Chu, Hsiao-Ting Tai, George F Gao, Bojian Zheng, Kazunari K Yokoyama, Jonathan M Austyn, Chen-Lung S Lin   +18 more
doaj   +1 more source