Results 61 to 70 of about 36,030 (253)

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, Volume 15, Issue 6, 9 February 2026.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Specific binding of HIV-1 envelope protein gp120 to the structural membrane proteins ezrin and moesin

Virus Research, 1997
The observation that HIV in vitro can infect CD4- and Gal-C-negative brain cell lines has stimulated this study to identify alternative gp120-binding proteins on brain cells. HIV-1 gp120 binding proteins of the CD4-negative and Gal-C-negative, non-productively infectable human glioblastoma cell line D54 were purified by affinity chromatography over a ...
Hecker, Claudia, Weise, Christoph, Schneider-Schaulies, Jürgen, Holmes, Harvey C, ter Meulen, Volker   +4 more
openaire   +2 more sources

Insights from the interfaces of HIV-1 envelope (ENV) trimer viral protein GP160 (GP120-GP41)

International Journal of Research in Pharmaceutical Sciences, 2021
The Human Immunodeficiency Virus (HIV-1) type 1 viral protein is a life threatening virus causing HIV/AIDS in infected humans. The HIV-1 envelope (ENV) trimer glycoprotein GP160 (GP120-GP41) is gaining attention in recent years as a potential vaccine candidate for HIV-1/AIDS.
null Christina Nilofer, null Arumugam Mohanapriya   +1 more
openaire   +1 more source

Glycosylation of the core of the HIV-1 envelope subunit protein gp120 is not required for native trimer formation or viral infectivity

Journal of Biological Chemistry, 2017
The gp120 subunit of the HIV-1 envelope (Env) protein is heavily glycosylated at ∼25 glycosylation sites, of which ∼7–8 are located in the V1/V2 and V3 variable loops and the others in the remaining core gp120 region.
Ujjwal Rathore, Piyali Saha, S. Kesavardhana, A. Kumar, R. Datta, Sivasankar Devanarayanan, R. Das, J. Mascola, R. Varadarajan   +8 more
semanticscholar   +1 more source

Direct interaction of HIV gp120 with neuronal CXCR4 and CCR5 receptors induces cofilin-actin rod pathology via a cellular prion protein- and NOX-dependent mechanism

PLoS ONE, 2021
Nearly 50% of individuals with long-term HIV infection are affected by the onset of progressive HIV-associated neurocognitive disorders (HAND). HIV infiltrates the central nervous system (CNS) early during primary infection where it establishes ...
L. K. Smith, Isaac W Babcock, L. Minamide, A. Shaw, J. Bamburg, T. Kuhn   +5 more
semanticscholar   +1 more source

Slit2/Robo4 signaling modulates HIV-1 gp120-induced lymphatic hyperpermeability.

PLoS Pathogens, 2012
Dissemination of HIV in the host involves transit of the virus and virus-infected cells across the lymphatic endothelium. HIV may alter lymphatic endothelial permeability to foster dissemination, but the mechanism is largely unexplored.
Xuefeng Zhang, Jinlong Yu, Paula M Kuzontkoski, Weiquan Zhu, Dean Y Li, Jerome E Groopman   +5 more
doaj   +1 more source

Surfactant Protein D modulates HIV infection of both T-cells and dendritic cells.

PLoS ONE, 2013
Surfactant Protein D (SP-D) is an oligomerized C-type lectin molecule with immunomodulatory properties and involvement in lung surfactant homeostasis in the respiratory tract.
Jens Madsen, Gaurav D Gaiha, Nades Palaniyar, Tao Dong, Daniel A Mitchell, Howard W Clark   +5 more
doaj   +1 more source

A mechanistic understanding of allosteric immune escape pathways in the HIV-1 envelope glycoprotein. [PDF]

PLoS Computational Biology, 2013
The HIV-1 envelope (Env) spike, which consists of a compact, heterodimeric trimer of the glycoproteins gp120 and gp41, is the target of neutralizing antibodies. However, the high mutation rate of HIV-1 and plasticity of Env facilitates viral evasion from
Anurag Sethi, Jianhui Tian, Cynthia A Derdeyn, Bette Korber, S Gnanakaran   +4 more
doaj   +1 more source

Broad and potent cross clade neutralizing antibodies with multiple specificities in the plasma of HIV-1 subtype C infected individuals. [PDF]

, 2017
Broadly Cross clade Neutralizing (BCN) antibodies are recognized as potential therapeutic tools and leads for the design of a vaccine that can protect human beings against various clades of Human Immunodeficiency Virus (HIV).
Ashokkumar, Manickam, Babu, Hemalatha, Buddolla, Viswanath, Chandrasekaran, Padmapriyadarsini, Cheedarla, Narayanaiah, Hanna, Luke Elizabeth, Kailasam, Nandagopal, Precilla, K Lucia, Ramanathan, VD, Sundaramurthi, Jagadish Chandrabose, Swaminathan, Soumya, Vaniambadi, S Kalyanaraman, Vijayan, KK Vidya   +12 more
core   +3 more sources

Accelerate the Highly Efficient Development of mRNA Vaccines Through Advanced Computational Methods

MedComm, Volume 7, Issue 2, February 2026.
This review explores the recent advancements in applying computational methods to optimize mRNA vaccines, with a primary focus on improvements in sequence design and delivery systems. ABSTRACT mRNA medicine is an emerging therapeutic approach that utilizes messenger RNA to synthesize functional proteins directly within target cells.
Ruichu Gu, Duanmiao Si, Dingwei Lei, Xiaoxue Xie, Yongge Li, Han Wen   +5 more
wiley   +1 more source