Results 91 to 100 of about 34,307 (290)

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Structural Insights into the Mechanisms of Action of Short-Peptide HIV-1 Fusion Inhibitors Targeting the Gp41 Pocket

Frontiers in Cellular and Infection Microbiology, 2018
The deep hydrophobic pocket of HIV-1 gp41 has been considered a drug target, but short-peptides targeting this site usually lack potent antiviral activity.
Xiujuan Zhang, Xiujuan Zhang, Yuanmei Zhu, Hao Hu, Senyan Zhang, Pengfei Wang, Huihui Chong, Jinsheng He, Xinquan Wang, Yuxian He   +9 more
doaj   +1 more source

Design of Novel HIV-1/2 Fusion Inhibitors with High Therapeutic Efficacy in Rhesus Monkey Models

, 2018
T-20 remains the only membrane fusion inhibitor available for the treatment of viral infection, but its relatively low anti-HIV activity and genetic barrier for drug resistance have significantly limited its clinical application.
Zhe Cong, Qiang Wei, Ting Chen, Chuan Qin, Jing Xue, Yuanmei Zhu, Yuxian He, Yan Guo, Yusen Zhou, Huihui Chong   +9 more
core   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

HIV-1 Entry, Inhibitors, and Resistance

Viruses, 2010
Entry inhibitors represent a new class of antiretroviral agents for the treatment of infection with HIV-1. While resistance to other HIV drug classes has been well described, resistance to this new class is still ill defined despite considerable clinical
Michael A. Lobritz, Annette N. Ratcliff, Eric J. Arts   +2 more
doaj   +1 more source

Covalent fusion inhibitors targeting HIV-1 gp41 deep pocket

, 2013
Covalent inhibitors form covalent adducts with their target, thus permanently inhibiting a physiological process. Peptide fusion inhibitors, such as T20 (Fuzeon, enfuvirtide) and C34, interact with the N-terminal heptad repeat of human immunodeficiency ...
Bi, Shuangyu, Qiu, Jiayin, Liu, Keliang, Liu, Shuwen, Bai, Yu, Cai, Lifeng, Lai, Luhua, Xue, Huifang, Wang, Kun, Cheng, Maosheng   +9 more
core   +1 more source

Surfactant protein D inhibits HIV-1 infection of target cells via interference with gp120-CD4 interaction and modulates pro-inflammatory cytokine production [PDF]

, 2014
© 2014 Pandit et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Al-Mozaini, MA, Pandit Hrishikesh, Yadav Ajit Kumar, Gopal, S, Idicula-Thomas, S, Uday Kishore (504246), Al-Mozaini Maha Ahmed, Vijay Kulkarni, Himangi Warke, Gopal Sandhya, Asif S Qaseem, Sonawani, A, Kulkarni, V, Warke Himangi, Hrishikesh Pandit, Patil, A, Himangi Warke (504243), Idicula-Thomas Susan, Anushree Patil (600836), Gajbhiye, R, Yadav, AK, Sandhya Gopal (600833), Kulkarni Vijay, Archana Sonawani (413679), Warke, H, Susan Idicula-Thomas, Taruna Madan, Sonawani Archana, Asif S. Qaseem, Maha Ahmed Al-Mozaini, Archana Sonawani, Hrishikesh Pandit (504240), Ajit Kumar Yadav (600834), Rahul Gajbhiye (600837), Qaseem, AS, Madan, T, Madan Taruna, Sandhya Gopal, Ajit Kumar Yadav, Qaseem Asif S., Gajbhiye Rahul, Rahul Gajbhiye, Patil Anushree, Pandit, H, Asif S. Qaseem (600835), Kishore Uday, Anushree Patil, Vijay Kulkarni (600838), Maha Ahmed Al-Mozaini (600839), Kishore, U, Taruna Madan (504241), Susan Idicula-Thomas (318974), Uday Kishore   +52 more
core   +1 more source

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

ADS-J21 is a novel HIV-1 entry inhibitor targeting gp41

Current Research in Microbial Sciences
HIV-1 envelope glycoprotein gp41 mediates fusion between HIV-1 and host cell membranes, making inhibitors of gp41 attractive anti-HIV drugs. We previously reported an efficient HIV-1 fusion inhibitor, ADS-J1, with a Y-shaped structure.
Ruiying Liang, Dou Dou, Chunying Wang, Shanshan Huo, Yang Wu, Juan Wang, Zhengsen Yu, Shuomin Zhang, Jingjing Xu, Yue Liu, Peng Liu, Shibo Jiang, Fei Yu   +12 more
doaj   +1 more source

N-Substituted Pyrrole Derivative 12m Inhibits HIV-1 Entry by Targeting Gp41 of HIV-1 Envelope Glycoprotein

Frontiers in Pharmacology, 2019
The combination of three or more antiviral agents that act on different targets is known as highly active antiretroviral therapy (HAART), which is widely used to control HIV infection. However, because drug resistance and adverse effects occur after long-
Jiayin Qiu, Jiayin Qiu, Jiayin Qiu, Taizhen Liang, Junyan Wu, Fei Yu, Fei Yu, Xiaoyang He, Yuanxin Tian, Lan Xie, Shibo Jiang, Shuwen Liu, Lin Li   +12 more
doaj   +1 more source