Results 101 to 110 of about 34,307 (290)

Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design

, 2014
Includes bibliographical references.Inducing broadly neutralizing antibodies targeting the HIV-1 envelope is thought to be crucial for developing an effective vaccine.
Jacob, Rajesh Abraham
core  

Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors [PDF]

, 2016
Background: HIV-1 typically develops resistance to any single antiretroviral agent. Combined anti-retroviral therapy to reduce drug-resistance development is necessary to control HIV-1 infection.
Maruta, Yasuhiro, Matsuoka, Masao, Masaru Yokoyama, Fujii, Nobutaka, Matsushita, Shuzo, Shinya Oishi, Yasuhiro Maruta, Ramirez Valdez, Kristel Paola, Oishi, Shinya, Takeo Kuwata, Sato, Hironori, Kristel Paola Ramirez Valdez, Yokoyama, Masaru, Kazuya Shimura, Nobutaka Fujii, Shimura, Kazuya, Shuzo Matsushita, Kuwata, Takeo, Tanaka, Kazuki, Kazuki Tanaka, Alam, Muntasir, Masao Matsuoka, Muntasir Alam, Hironori Sato   +23 more
core   +1 more source

Lithium Diisopropylamide‐Mediated Ring‐Opening of Tetrahydrofuran in the Synthesis of Polyhydroxylated Indolizidines

European Journal of Organic Chemistry, EarlyView.
Chiral tri‐ and pentahydroxy spirocyclopentane‐indolizidines were synthesized using lithium diisopropylamide “LDA” promoted diallylation and tetrahydrofuran “THF” ring‐opening in a one‐pot procedure as a key step. The sequence leading to the targeted hydroxy‐spiroindolizidines was achieved by cis‐dihydroxylation followed by reduction of the enamine and
Paula Fraňová, Peter Šafář, Marchalín Štefan, Petra Pažitná, Ivana Žídeková, Ján Moncol, Adam Daïch   +6 more
wiley   +1 more source

Twenty-six years of HIV science: an overview of anti-HIV drugs metabolism

Brazilian Journal of Pharmaceutical Sciences, 2011
From the identification of HIV as the agent causing AIDS, to the development of effective antiretroviral drugs, the scientific achievements in HIV research over the past twenty-six years have been formidable.
Carolina Horta Andrade, Lenis Medeiros de Freitas, Valéria de Oliveira   +2 more
doaj   +1 more source

Development of Pentaplex Reverse Transcription Droplet Digital PCR Assay for Simultaneous Detection and Absolute Quantification of HIV‐1, HIV‐2, HCV, and HBV With Internal Control

ELECTROPHORESIS, EarlyView.
Development of Pentaplex reverse transcription droplet digital PCR assay for simultaneous detection and absolute quantification of HIV‐1, HIV‐2, HCV, and HBV with internal control. The channel‐resolved multiplex strategy enables high sensitivity, robust quantification, and scalable digital PCR workflows across platforms.
Soo Yeon Lim, Un Na Koh, Ah Leum Kim, Yebin Kim, Ga Eun Kim, Si‐Keun Lim   +5 more
wiley   +1 more source

Autographa californica Multicapsid Nucleopolyhedrovirus efficiently infects Sf9 cells and transduces mammalian cells via direct fusion with the plasma membrane at low pH

, 2010
The budded virus (BV) of the Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) infects insect cells and transduces mammalian cells mainly through the endocytosis pathway.
F. Deng, M. Wang, Dong, S., Vlak, J.M., Deng, F., S. Dong, Wang, M., Qiu, Z., Z. Hu, Hu, Z.H., J. M. Vlak, H. Wang, Z. Qiu, Wang, H.L.   +13 more
core   +1 more source

Nanophotonic Biosensors and the Paradigm of Trans‐Scale Autonomous Bio‐Integrated Diagnostics for Addressing Health Complexities

Electron, EarlyView.
Physics‐driven advances in optical nanobiosensors for rapid, miniaturized, and point‐of‐care diagnostics for next‐generation decentralized and personalized healthcare based on sensor intelligence. ABSTRACT Public health emergencies and the escalating burden of chronic diseases necessitate a paradigm shift from centralized laboratory testing to rapid ...
Vishal Chaudhary, Harsh Sable, Sonu Sonu, Lakshita Phor, Reddicherla Umapathi, Pradeep Bhadola   +5 more
wiley   +1 more source

Investigating the role of a conserved hydrophobic pocket of gp41 in the anti-HIV activity of fusion inhibitors. [PDF]

Protein Sci
Abstract Membrane fusion between HIV and host cells requires interaction between the N‐terminal and C‐terminal repeat regions (NHR and CHR) of the gp41 envelope subunit. A deep hydrophobic pocket (HP) on the surface of NHR is considered crucial in this interaction.
Polo-Megías D, Cano-Muñoz M, Sánchez-Martínez L, Lestani S, Moog C, Decoville T, Salinas-García MC, Gavira JA, Cámara-Artigas A, Conejero-Lara F.   +9 more
europepmc   +2 more sources

Inhibitory activities of fusion inhibitors against divergent HIV-1 subtypes^a.

, 2019
Inhibitory activities of fusion inhibitors against divergent HIV-1 subtypesa.
Ting Chen (15205), Jing Xue (170229), Qiang Wei (187077), Chuan Qin (235858), Zhe Cong (452962), Yuanmei Zhu (4497892), Huihui Chong (330720), Yuxian He (277042)   +7 more
core   +1 more source

Inhibitory activities of fusion inhibitors against replication-competent HIV-1 isolates^a.

, 2019
Inhibitory activities of fusion inhibitors against replication-competent HIV-1 isolatesa.
Ting Chen (15205), Jing Xue (170229), Qiang Wei (187077), Chuan Qin (235858), Zhe Cong (452962), Yuanmei Zhu (4497892), Huihui Chong (330720), Yuxian He (277042)   +7 more
core   +1 more source