Results 141 to 150 of about 33,240 (248)

A Double-Edged Sword: Extracellular Serine Proteases as Facilitators of Infection and Mediators of Immunity. [PDF]

Molecules
Shagirova A, Allayarova M, Makhanova A, Bekturgan A, Burster T.   +4 more
europepmc   +1 more source

Lack of Differences in the Pharmacokinetics of Therapeutic Monoclonal Antibodies Between Japanese and Non‐Japanese Individuals

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Evaluation of the pharmacokinetics (PK) of new drugs in Japanese individuals is regularly requested by the Japanese regulatory agency prior to participation in global clinical trials or for bridging approaches for regulatory approval. However, the need for PK assessments in the Japanese population may be less compelling for monoclonal ...
Paridhi Gupta, Ashish Sharma, Bernd Meibohm   +2 more
wiley   +1 more source

HIV-1 Resistance to Dolutegravir in Benin: The Need to Improve and Strengthen Therapeutic Patient Education Strategies to Achieve the Third Objective 95 of UNAIDS 95-95-95 Target. [PDF]

Case Rep Infect Dis
Tchiakpe E, Diop-Ndiaye H, Osawe S, Toure-Kane C, Yessoufou A.   +4 more
europepmc   +1 more source

Downstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy, primarily affecting skeletal muscle and leading to premature death. Although the loss of dystrophin has long been recognised as the primary cause of the disease, no definitive cure is currently available. As a consequence, therapeutic efforts
Raffaele Epis, Gabriele Rovetta, Giulia Ferrari, Chiara Bonfanti, Giorgia Careccia, Graziella Messina   +5 more
wiley   +1 more source

From Envelope to Encephalopathy: How HIV-1 gp120 Drives Neurocognitive Decline. [PDF]

Viruses
Santerre M, Shrestha J, Allen CNS, Shcherbik N, Sawaya BE.   +4 more
europepmc   +1 more source

An Epstein‐Barr Virus Nuclear Antigen 1 (EBNA1) Serology Test Strip for Nasopharyngeal Carcinoma Risk Screening

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT Antibodies to Epstein‐Barr virus (EBV) proteins can predict nasopharyngeal carcinoma (NPC) risk. We previously defined a prototype EBNA1 protein panel and multiplex immunoblot assay that distinguishes NPC risk several years pre‐diagnosis.
Benjamin E. Warner, Japan Patel, Rebecca Satterwhite, Renwei Wang, Jennifer Adams‐Haduch, Woon‐Puay Koh, Jian‐Min Yuan, Kathy H. Y. Shair   +7 more
wiley   +1 more source

Transcriptional and epigenetic regulation of autophagy: mechanisms, disease relevance and therapeutic opportunities. [PDF]

Signal Transduct Target Ther
Seo J, Park SY, Lee DC, Yoo W, Yang YR, Seo HW, Park JL, Joo JY, Park KC, Byun S.   +9 more
europepmc   +1 more source

In‐Vitro Evaluation of HIV/SARS‐CoV‐2 Co‐Infection Mediated Proteomic Changes in Astrocytes and Pericytes Reveals Altered Signaling Pathways Associated With Neurodegenerative Disorders

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT Coronavirus disease 2019 (COVID‐19) survivors frequently experience a wide range of symptoms known as post‐acute sequelae of SARS‐CoV‐2 (PASC) or long COVID. Importantly, complications arising from microvascular dysfunction, blood‐brain barrier (BBB) disruption, and chronic neuroinflammation have been implicated in driving PASC within the ...
Arpan Acharya, Michellie Thurman, Debapriya Sutar, Oluwatayo Israel Olasunkanmi, Johid R. Malik, Shetty Ravi Dyavar, Ákos Végvári, Siddappa N. Byrareddy   +7 more
wiley   +1 more source

Potent <i>in vitro</i> synergistic antiviral effects of the pan-coronavirus fusion inhibitor EK1 in combination with RBD-specific antibodies or M^pro inhibitors. [PDF]

J Virol
Xiu R, Wang Y, Cai W, Wang Q, Xie M, Wang Y, Li C, Wang Q, Huang J, Ying T, Song C, Lu L, Jiang S, Xu W.   +13 more
europepmc   +1 more source

Early‐Onset Prostate Cancer: Epidemiology, Risk Factors, Biology, Clinical Features, Management, and Early Detection

MedComm, Volume 7, Issue 8, August 2026.
EOPC is a distinct clinicopathological entity separable from SOPC, differing fundamentally in genetic susceptibility, TMPRSS2:ERG fusion frequency, and survival outcomes. Although research remains nascent, this review provides the first comprehensive synthesis of current evidence, offering a critical foundation to guide future investigations into this ...
Xingyu Xiong, Weizhen Zhu, Weichao Huang, Shiyu Zhang, Qi Deng, Jie Yang, Hang Xu, Qiang Wei, Lu Yang   +8 more
wiley   +1 more source