Results 161 to 170 of about 33,240 (248)

HIV-1 signalling remodels nuclear pores to licence infection. [PDF]

Nature
Mesner D, Whelan MVX, Shivkumar M, Reuschl AK, Chiozzi RZ, Thalassinos K, de Bruin RAM, Jolly C.   +7 more
europepmc   +1 more source

Recent Advances in the Molecular Mechanisms of Bacterial Anti‐Phage Defence Systems

Microbial Biotechnology, Volume 19, Issue 8, August 2026.
Panoptes as an example for an antiphage system consists of OptS producing a cyclic dinucleotide that prevents activation of OptE, a transmembrane protein. Phage T4 infection introduces the sponge protein Acb2 that adsorbs the cyclic dinucleotide thus activating OptE which disrupts the cell membrane aborting phage infection.
Harald Brüssow
wiley   +1 more source

The evolving role of structural biology in pharma: integration of X-ray crystallography, cryo-electron microscopy and beyond. [PDF]

Acta Crystallogr D Struct Biol
Chrencik JE, Su HP, Gomez Llorente Y, Palte RL, Klein DJ, Hayes RP, Antine SP, Asmar-Rovira GA, Bertoletti N, Byrne NJ, Carroll BL, Cordeiro CD, Curfman K, Dutko J, Eddins MJ, Fischmann T, Govindarajan B, Hecksel CW, Ho T, Hollenstein K, Hong MR, Hruza A, Ishchenko A, Jaime-Garza M, Jaremko MJ, Knox HL, Kostas J, Krishnamurthy H, Manolaridis I, Noland CL, Partridge AT, Patel SB, Reichert P, Reid JC, Felisberto-Rodrigues C, Shintre CA, Shipman JM, Tamilselvan E, Walker ME, Walker SN, Wang R, Wright KM, Yen TJ, Yoo BK, Gabelli SB.   +44 more
europepmc   +1 more source

Chemokines in Alzheimer's Disease: Early Defence, Late Damage and the Impact of Sex and Infection

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.
ABSTRACT Chemokines constitute a versatile signalling network maintaining homeostasis and glia–neuron communication in the healthy brain but become progressively dysregulated during aging and Alzheimer's disease (AD). This review examines how chemokine systems transition from tightly regulated homeostatic signals to drivers of chronic neuroinflammation
Blanca I. Aldana, Kristine Freude
wiley   +1 more source

Surface Plasmon Resonance as a Tool in Antiviral Drug Discovery Research. [PDF]

Biosensors (Basel)
Wegrzyn KE, Matsoukas JM.
europepmc   +1 more source

A Proposed Clinical Diagnostic Framework for Short Telomere Syndrome

Clinical Genetics, Volume 110, Issue 2, Page 139-149, August 2026.
We propose a phenotype‐based diagnostic framework for short telomere syndrome that integrates age‐adjusted telomere length, phenotypic manifestations, and genetic findings, where available. The framework is intended to guide clinical evaluation, longitudinal surveillance, and individualized management while acknowledging limitations in current telomere
Andrew Courtwright, Richard A. King, Jennie Vagher, Cate T. Levy, Juan Gallegos F. Orozco, Luis FZ Batista, Afaf Osman, Srinivas Tantavahi, Mary Beth Scholand   +8 more
wiley   +1 more source

Interferon-induced transmembrane proteins: membrane gatekeepers of fusion and infection. [PDF]

Front Cell Infect Microbiol
Amoueian M, Liu Q, Tritten L.
europepmc   +1 more source

The Evolving Landscape of Pulmonary Hypertension Treatment: From Vasodilation to Disease Modification

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Pulmonary hypertension (PH) is a complex disorder associated with significant morbidity and mortality. PH is characterized by an elevated pulmonary vascular load, leading to right ventricular dysfunction and remodeling, with right heart failure and premature death if left untreated.
Surya Ayalasomayajula, Ednan K. Bajwa, Alexandra G. Cornell, Maria Jose Loureiro, Samuel S. Kim, Julia Richmond DiBello, Eric Sterner, Richard Chen, Islam R. Younis   +8 more
wiley   +1 more source

Classic Kaposi Sarcoma: Current Treatment Strategies and Emerging Therapeutic Approaches. [PDF]

Cancers (Basel)
Revenko D, Shirron N, Shainer R, Avitan-Hersh E, Zer A.   +4 more
europepmc   +1 more source

Resistance‐exercise‐induced stress intervenes in TGF‐β signaling by cooperatively downregulating nuclear αB‐crystallin and SMAD4 in human skeletal muscle fibers

The FEBS Journal, Volume 293, Issue 15, Page 4624-4644, August 2026.
Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf, Cassandra Duda, Tihomir Kostov, Patrick Diel, Käthe Bersiner, Wilhelm Bloch, Sebastian Gehlert, Daniel Jacko   +7 more
wiley   +1 more source