Results 181 to 190 of about 34,307 (290)

Nanobody-Based Bioconjugates as Potent and Broadly Active Inhibitors of HIV Entry. [PDF]

J Am Chem Soc
Saha SJ, Kumariya R, Davis PA, Tourtellott E, Doria-Rose N, Bewley CA, Cheloha RW.   +6 more
europepmc   +1 more source

TopCas: Topology‐Gated Cas12a via DNA‐RNA Chimeric Circular crRNA for Amplification‐Free Nucleic Acid Detection and Conditional Gene Editing

Advanced Science, Volume 13, Issue 33, 15 June 2026.
The TopCas platform utilizes an engineered DNA‐RNA chimeric circular crRNA to establish topology‐gated control over CRISPR‐Cas12a activity, enabling target‐triggered self‐catalytic amplification (preamplification‐free). This system seamlessly integrates highly sensitive molecular diagnostics with conditionally controlled gene editing, demonstrating ...
Shun Zhang, Wen Sun, Ting Xiao, Yali Wang, Xianlan Wu, Huiyou Chen, Ming Chen, Jun Zhang   +7 more
wiley   +1 more source

TMEM259/MEMBRALIN is a non-canonical ER-phagy receptor that associates with MAN1B1 and VCP to eliminate viral glycoproteins. [PDF]

Autophagy Rep
Camilleri JM, Zhang J, Wang T, Ahmad I, Li S, Zheng YH.   +5 more
europepmc   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1552-1566, June 2026.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

A Double-Edged Sword: Extracellular Serine Proteases as Facilitators of Infection and Mediators of Immunity. [PDF]

Molecules
Shagirova A, Allayarova M, Makhanova A, Bekturgan A, Burster T.   +4 more
europepmc   +1 more source

Case Report: Synchronous Manifestations of Kaposi Sarcoma Herpesvirus‐Associated Disorders

Cancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background Kaposi sarcoma herpes virus (KSHV) is associated with multiple clinical manifestations, including primary effusion lymphoma, an aggressive CD38+ B cell lymphoma with a plasmablastic phenotype. Case This case describes an antiretroviral therapy‐adherent person with HIV who presented with concurrent KSHV‐related disorders of Kaposi ...
Kandice Roberts, Paula Valiño Ramos, Saurabh Jindal, Vikas Prasad, Yi Shan Lee, Mariam Khanfar, Obi L. Griffith, Malachi Griffith, Jeanne Jiang, Ethel Cesarman, Daniel Rauch, Paul Simonson, Thomas Odeny, Lee Ratner   +13 more
wiley   +1 more source

Transcriptional and epigenetic regulation of autophagy: mechanisms, disease relevance and therapeutic opportunities. [PDF]

Signal Transduct Target Ther
Seo J, Park SY, Lee DC, Yoo W, Yang YR, Seo HW, Park JL, Joo JY, Park KC, Byun S.   +9 more
europepmc   +1 more source

CCR5 Utilization of Transmitted and Early Founder HIV-1 Envelopes and the Sensitivity to Small CCR5 Inhibitors

, 2008
Huang, X, Hu, Q, Shattock, RJ
core  

The Chemical Structures, Neuroprotective Effects, Structure–Activity Relationships, and Applications of Flavonoids, Phenolic Acids, Terpenoids, and Sterols in Dandelion: A Review

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
This review systematically summarizes the chemical structures and structure–activity relationships of key bioactive compounds in dandelion, including flavonoids, phenolic acids, terpenoids, and sterols. It highlights their neuroprotective mechanisms against neuroinflammation and oxidative stress, while outlining their promising dual applications in the
Hongye Li, Bingchan Qu, Jiasu Wu, Menghan Sun, Youlin Xue, Tiejing Li, Chang Tan, Shan Wang, Chong Ning, Chongting Guo   +9 more
wiley   +1 more source

From Envelope to Encephalopathy: How HIV-1 gp120 Drives Neurocognitive Decline. [PDF]

Viruses
Santerre M, Shrestha J, Allen CNS, Shcherbik N, Sawaya BE.   +4 more
europepmc   +1 more source