Recent Developments in HIV Antivirals: The Prospect of Prophylactic Drugs to Change the Pandemic. [PDF]
Brüssow H.
europepmc +1 more source
Pellagra in Contemporary Clinical Practice (2000–2023): A Systematic Review
This systematic review (2000–2023) of 1212 cases highlights pellagra's evolving etiology. While primary dietary deficiency (85%) persists in humanitarian crises, secondary forms from alcohol misuse (9.6%), isoniazid (14.3% of drug‐related cases), and malabsorption are rising.
Noureddine Litaiem +2 more
wiley +1 more source
A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV. [PDF]
Leite DI +11 more
europepmc +1 more source
Machine Learning of Personal Repertoires From Public T Cell Receptors
ABSTRACT The T‐cell receptor (TCR) repertoire records an individual's immunological history, but most unique CDR3 sequences in any one person are private and uninformative about anyone else. A small subset, however, recurs predictably across unrelated donors.
Or Malca, Alona Zilberberg, Sol Efroni
wiley +1 more source
The Emerging Promise of Pentacyclic Triterpenoid Derivatives as Novel Antiviral Agents Against SARS-CoV-2 Variants. [PDF]
Wan X +6 more
europepmc +1 more source
Counteracting Influenza Virus Evolution Through the Full Spectrum of Broadly Protective Antibodies
ABSTRACT Despite the presence of licensed vaccines and therapeutics, influenza viruses remain a major public health concern, as they cause seasonal respiratory infections and pose a pandemic threat through the emergence of zoonotic strains. Although neutralizing antibodies elicited by seasonal vaccination constitute a primary defense against infection,
Yu Adachi, Yoshimasa Takahashi
wiley +1 more source
Furin as a Novel Pan-Viral Therapeutic Target: Implications for Dengue and SARS-CoV-2. [PDF]
Shalaby L +4 more
europepmc +1 more source
Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity
ABSTRACT Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk.
Cynthiya Shrestha +2 more
wiley +1 more source
Advancements in development of novel class of HIV protease inhibitors. [PDF]
Gu WG, Yin GZ, Zhang YP.
europepmc +1 more source
GC B Cells, Tfh Cells, and Influenza bnAbs: Insights for Improving Universal Vaccine Design
ABSTRACT Antibodies are crucial for providing protection against influenza virus infection; however, protective humoral immunity is limited by antigenic drift and shift. Hence, the discovery of broadly neutralizing antibodies (bnAbs) targeting conserved epitopes on hemagglutinin protein evokes the hope of developing a universal influenza vaccine ...
Takeshi Inoue +2 more
wiley +1 more source

