Results 41 to 50 of about 28,737 (162)

Position effects influence HIV latency reversal [PDF]

Nature Structural & Molecular Biology, 2016
The main obstacle to curing HIV is the presence of latent proviruses in the bodies of infected patients. The partial success of reactivation therapies suggests that the genomic context of integrated proviruses can interfere with treatment. Here we developed a method called Barcoded HIV ensembles (B-HIVE) to map the chromosomal locations of thousands of
Heng-Chang Chen, Javier P Martinez, Eduard Zorita, Andreas Meyerhans, Guillaume J Filion   +4 more
openaire   +3 more sources

Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation.

PLoS Pathogens, 2016
Identifying host immune determinants governing HIV transcription, latency and infectivity in vivo is critical to developing an HIV cure. Based on our recent finding that the host factor p21 regulates HIV transcription during antiretroviral therapy (ART),
Mohamed Abdel-Mohsen, Leonard Chavez, Ravi Tandon, Glen M Chew, Xutao Deng, Ali Danesh, Sheila Keating, Marion Lanteri, Michael L Samuels, Rebecca Hoh, Jonah B Sacha, Philip J Norris, Toshiro Niki, Cecilia M Shikuma, Mitsuomi Hirashima, Steven G Deeks, Lishomwa C Ndhlovu, Satish K Pillai   +17 more
doaj   +1 more source

Understanding HIV Latency: The Road to an HIV Cure [PDF]

Annual Review of Medicine, 2015
Treatment with antiretroviral therapy dramatically increases the survival of HIV-infected individuals. However, treatment has to be continued for life because it does not lead to the full eradication of infection. HIV persists in resting CD4+ T cells, and possibly other cell types, and can reemerge from these cells when therapy is interrupted.
Matthew S, Dahabieh, Emilie, Battivelli, Eric, Verdin   +2 more
openaire   +2 more sources

Mathematical Models of HIV Latency [PDF]

, 2017
Viral latency is a major barrier to curing HIV infection with antiretroviral therapy, and consequently, for eliminating the disease globally. The establishment, maintenance, and potential clearance of latent infection are complex dynamic processes and can be best understood and described with the help of mathematical models.
openaire   +2 more sources

Natural products against HIV latency

Acupuncture and Herbal Medicine, 2021
Abstract Antiretroviral therapy has achieved great success in suppressing human immunodeficiency virus (HIV) replication and transforming HIV infection from a fatal disease to a manageable chronic disease. However, the latent HIV reservoir persists in the body of HIV-infected individuals and is prone to reactivation. Therefore,
Kouharu Otsuki, Mi Zhang, Wei Li
openaire   +2 more sources

HIV Latency: Present Knowledge and Future Directions [PDF]

Future Virology, 2006
Current therapies do not eradicate HIV from infected patients. Indeed, HIV hides in a latent form insensitive to these therapies. Thus, one priority is to purge these latent reservoirs. But what mechanisms are responsible for latency and what are the reservoirs of latently infected cells?
Xavier, Contreras, Tina, Lenasi, B Matija, Peterlin   +2 more
openaire   +2 more sources

Combined noncanonical NF-κB agonism and targeted BET bromodomain inhibition reverse HIV latency ex vivo

The Journal of Clinical Investigation, 2022
Latency reversal strategies for HIV cure using inhibitor of apoptosis protein (IAP) antagonists (IAPi) induce unprecedented levels of latent reservoir expression without immunotoxicity during suppressive antiretroviral therapy (ART).
Shane D. Falcinelli, Jackson J. Peterson, Anne-Marie W. Turner, David Irlbeck, Jenna Read, Samuel L.M. Raines, Katherine S. James, Cameron Sutton, Anthony Sanchez, Ann Emery, Gavin Sampey, Robert Ferris, Brigitte Allard, Simon Ghofrani, Jennifer L. Kirchherr, Caroline Baker, JoAnn D. Kuruc, Cynthia L. Gay, Lindsey I. James, Guoxin Wu, Paul Zuck, Inmaculada Rioja, Rebecca C. Furze, Rab K. Prinjha, Bonnie J. Howell, Ronald Swanstrom, Edward P. Browne, Brian D. Strahl, Richard M. Dunham, Nancie M. Archin, David M. Margolis   +30 more
doaj   +1 more source

HIV Latency Is Established Directly and Early in Both Resting and Activated Primary CD4 T Cells. [PDF]

PLoS Pathogens, 2015
Highly active antiretroviral therapy (HAART) suppresses human immunodeficiency virus (HIV) replication to undetectable levels but cannot fully eradicate the virus because a small reservoir of CD4+ T cells remains latently infected.
Leonard Chavez, Vincenzo Calvanese, Eric Verdin   +2 more
doaj   +1 more source

[Molecular basis of HIV-1 latency - part I: physiology of HIV-1 latency].

Medecine sciences : M/S, 2010
L’introduction de la multithérapie active en 1996 s’est avérée très efficace et avait entretenu l’espoir d’éradiquer le virus du Sida. Malheureusement, des obstacles à son éradication sont rapidement apparus, notamment la mise en évidence du phénomène de latence virale dans les principales cellules cibles du virus, dont les lymphocytes T CD4+ et les ...
Schwartz, Christian, Le Douce, Valentin, Cherrier, Thomas, Redel, Laetitia, Marban-Doran, Celine, Aunis, Dominique, Rohr, Olivier   +6 more
openaire   +2 more sources

HIV-1 Latency and Latency Reversal: Does Subtype Matter? [PDF]

Viruses, 2019
Cells that are latently infected with HIV-1 preclude an HIV-1 cure, as antiretroviral therapy does not target this latent population. HIV-1 is highly genetically diverse, with over 10 subtypes and numerous recombinant forms circulating worldwide. In spite of this vast diversity, much of our understanding of latency and latency reversal is largely based
Indra Sarabia, Alberto Bosque
openaire   +2 more sources