Results 51 to 60 of about 28,737 (162)
Biomolecules, 2023 The “block and lock” strategy is one approach that might elicit a sterilizing cure for HIV-1 infection. The “block” refers to a compound’s ability to inhibit latent HIV-1 proviral transcription, while the “lock” refers to its capacity to induce permanent
Benni Vargas +3 more
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The BAF complex and HIV latency [PDF]
Transcription, 2012 The persistence of a reservoir of transcriptionally competent but latent virus in the presence of antiviral regimens presents the main impediment to a curative therapy against HIV. Therefore it is critical to understand the molecular mechanisms, which lead to the establishment and maintenance of HIV latency, and which contribute to the reversal of this
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Identification of unrecognized host factors promoting HIV-1 latency.
PLoS Pathogens, 2020 To counter HIV latency, it is important to develop a better understanding of the full range of host factors promoting latency. Their identification could suggest new strategies to reactivate latent proviruses and subsequently kill the host cells ("shock ...
Zichong Li +2 more
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Histone deacetylase inhibitors and HIV latency [PDF]
Current Opinion in HIV and AIDS, 2011 Interest has re-emerged in approaches to eradicate HIV infection. A series of modifications of nucleosomal histones within chromatin are a key mechanism of HIV gene regulation that alters the recruitment of transcription factors to viral DNA. The balance of these histone modifications in the vicinity of the HIV LTR plays an important role in the ...
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Epigenetic Heterogeneity in HIV-1 Latency Establishment [PDF]
Scientific Reports, 2015 Despite prolonged antiretroviral therapy, HIV-1 persists as transcriptionally inactive proviruses. The HIV-1 latency remains a principal obstacle in curing AIDS. It is important to understand mechanisms by which HIV-1 latency is established to make the latent reservoir smaller. We present a molecular characterization of distinct populations at an early
Matsuda, Yuka +5 more
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Long non-coding RNAs and latent HIV - A search for novel targets for latency reversal.
PLoS ONE, 2019 The latent cellular reservoir of HIV is recognized as the major barrier to cure from HIV infection. Long non-coding RNAs (lncRNAs) are more tissue and cell type-specific than protein coding genes, and may represent targets of choice for HIV latency ...
Wim Trypsteen +10 more
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Latency: the hidden HIV-1 challenge [PDF]
Retrovirology, 2006 AbstractEradication of HIV-1 from an infected individual cannot be achieved by current regimens. Viral reservoirs established early during the infection remain unaffected by anti-retroviral therapy for a long time and are able to replenish systemic infection upon interruption of the treatment.
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Epitranscriptomic m6A modifications during reactivation of HIV-1 latency in CD4+ T cells
mBioDespite effective antiretroviral therapy reducing HIV-1 viral loads to undetectable levels, the presence of latently infected CD4+ T cells poses a major barrier to HIV-1 cure.
Tarun Mishra +5 more
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HIV latency: experimental systems and molecular models [PDF]
FEMS Microbiology Reviews, 2012 Highly active antiretroviral therapy (HAART) has shown great efficacy in increasing the survival of HIV infected individuals. However, HAART does not lead to the full eradication of infection and therefore has to be continued for life. HIV persists in a transcriptionally inactive form in resting T cells in HAART-treated patients and can be reactivated ...
Shweta, Hakre +3 more
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Targeting HIV latency: pharmacologic strategies toward eradication [PDF]
Drug Discovery Today, 2013 The latent reservoir for HIV-1 in resting CD4(+) T cells remains a major barrier to HIV-1 eradication, even though highly active antiretroviral therapy (HAART) can successfully reduce plasma HIV-1 levels to below the detection limit of clinical assays and reverse disease progression.
Sifei, Xing, Robert F, Siliciano
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