Results 211 to 220 of about 58,529 (279)

Navigating infection by pathogenic spirochetes: The host‐bacteria interface at the atomic level

Protein Science, Volume 34, Issue 7, July 2025.
Abstract Pathogenic spirochetes bind and interact with various host structures and molecules throughout the course of infection. By utilizing their outer surface molecules, spirochetes can effectively modulate their dissemination, interact with immune system regulators, and select specific destination niches within the host.
Libor Hejduk, Norbert Müller, Adriana Rathner, Ján Štěrba, Shang‐Cheng Hung, Chia‐Lin Chyan, Ryan O. M. Rego, Martin Strnad   +7 more
wiley   +1 more source

Integrative Computational Approaches for Understanding Drug Resistance in HIV-1 Protease Subtype C. [PDF]

Viruses
Venkatachalam S, Muralidharan N, Pandian R, Sayed Y, Gromiha MM.   +4 more
europepmc   +1 more source

HIV protease inhibitors block streptolysin S production. [PDF]

ACS Chem Biol, 2015
Maxson T, Deane CD, Molloy EM, Cox CL, Markley AL, Lee SW, Mitchell DA.   +6 more
europepmc   +1 more source

Protease sequences from HIV-1 group M subtypes A???H reveal distinct amino acid mutation patterns associated with protease resistance in protease inhibitor-naive individuals worldwide

, 2000
Danuta Pieniążek, Mark A. Rayfield, Dale J. Hu, John N. Nkengasong, Stefan Z. Wiktor, R. G. Downing, Benon Biryahwaho, Timothy D. Mastro, Amílcar Tanuri, Vincent Soriano, Renu B. Lal, Timothy J. Dondero   +11 more
openalex   +1 more source

Aminoisothiazolamides, a new class of potent inhibitors of lysyl‐tRNA synthetase

Pest Management Science, Volume 81, Issue 7, Page 3956-3983, July 2025.
The present work covers a series of novel herbicidal lead structures that possess an aminoisothiazolamide scaffold as a structural key feature. Lysyl‐tRNA synthetase 1 (KRS1) was identified as the biochemical mode‐of‐action. Based on optimized and tailored synthetic approaches, a broader SAR study was carried out delivering some lead structures that ...
David Bernier, David M Barber, Guido Bojack, Birgit Bollenbach‐Wahl, Luke Churchman, Uwe Döller, Tyler Fahrenhorst‐Jones, Jörg Freigang, Elmar Gatzweiler, Claudia Hartfiel, Caroline Hilmi, Yoann Huet, Bernd Laber, Gudrun Lange, Stephanie Lee, Virginie Lempereur, Marc Mosrin, Thomas Müller, China M Payne, Olaf Peters, Luka Posa, Shaun Rees, Anna M Reingruber, Jullien Rey, Jörg Tiebes, Karen Tilmant, Jens Frackenpohl   +26 more
wiley   +1 more source

Near‐Infrared Fluorescent Single‐Walled Carbon Nanotubes for Biosensing

Small, Volume 21, Issue 26, July 3, 2025.
Near‐infrared fluorescent single‐walled carbon nanotubes (SWCNTs) stand out as versatile biosensors due to their spectral overlap with the biological transparency window, surface‐sensitive fluorescence emission, and chemical modularity. This review offers a concise guide to understanding the photophysics of SWCNTs, various functionalization strategies,
Srestha Basu, Gili Bisker
wiley   +1 more source

Accurate Prediction of Drug Activity by Computational Methods: Importance of Thermal Capacity. [PDF]

Molecules
Palese LL.
europepmc   +1 more source

Efficacy and tolerability of pravastatin for the treatment of HIV-1 protease inhibitor-associated hyperlipidaemia: a pilot study

, 2000
Francesco Baldini, Simona Di Giambenedetto, Antonella Cingolani, Rita Murri, Adriana Ammassari, Andrea De Luca   +5 more
openalex   +1 more source

TLR7 Mediates HIV‐1 Tat‐Induced Cellular Senescence in Human Astrocytes

Aging Cell, Volume 24, Issue 7, July 2025.
Once internalized into endolysosomes, HIV‐1 Tat interacts and activates TLR7, causing endolysosome damage. Such interaction between HIV‐1 Tat and TLR7 also leads to a senescence‐like phenotype in astrocytes, including cell cycle arrest, elevated levels of p21 and p16 proteins, increased SA‐β‐gal activity, and enhanced secretion of SASP factors ...
Neda Rezagholizadeh, Gaurav Datta, Wendie A. Hasler, Erica C. Nguon, Elise V. Smokey, Xuesong Chen   +5 more
wiley   +1 more source

Targeting the AKT pathway: Repositioning HIV protease inhibitors as radiosensitizers.

Indian J Med Res, 2016
Goda JS, Pachpor T, Basu T, Chopra S, Gota V.   +4 more
europepmc   +1 more source