Results 231 to 240 of about 260,498 (362)

Ions and Inhibitors in the Binding Site of HIV Protease: Comparison of Monte Carlo Simulations and the Linearized Poisson-Boltzmann Theory [PDF]

, 2009
Dezső Boda, Mónika Valiskó, Douglas Henderson, Dirk Gillespie, Bob Eisenberg, Michael K. Gilson   +5 more
openalex   +1 more source

Site‐Specific Mitochondrial RNA N1‐Methyladenosine Demethylation via an Engineered MTS‐PUF‐ALKBH3 Fusion Protein

Advanced Science, Volume 13, Issue 1, 5 January 2026.
A CRISPR‐free mitochondrial RNA m1A demethylation (MRD) editor combining MTS, PUF proteins, and ALKBH3 enables precise m1A removal from mitochondrial mRNA and tRNA, which influences mitochondrial protein levels, cellular proliferation, ATP production, and mitochondrial respiration. Subsequently, in vivo demethylation of the m1A modification is achieved
Xiangrui Li, Deqiang Kong, Hongmei Liu, Jie Yang, Jiale Zhou, Yuqiang Qian, Ding Zhao, Jinze Li, Xinyu Wu, Tao Zhang, Xiaodi Sun, Yang Han, Liangxue Lai, Zhanjun Li   +13 more
wiley   +1 more source

Coupling of an Acyl Migration Prodrug Strategy with Bio-activation To Improve Oral Delivery of the HIV-1 Protease Inhibitor Atazanavir

, 2018
Murugaiah A. M. Subbaiah, Nicholas A. Meanwell, John F. Kadow, Lakshumanan Subramani, Mathiazhagan Annadurai, Thangeswaran Ramar, Salil D. Desai, Sarmistha Halder Sinha, Murali Subramanian, Sandhya Mandlekar, Srikanth Sridhar, Shweta Padmanabhan, Priyadeep Bhutani, Rambabu Arla, Susan M. Jenkins, Mark Krystal, Chunfu Wang, Ramakanth Sarabu   +17 more
openalex   +1 more source

Quantitative Structure-Activity Relationship Studies on Cyclic Urea-Based HIV Protease Inhibitors [PDF]

, 1998
Satya P. Gupta, Surendra Babu Manabolu Surya, Rajni Garg, S. Sowmya Kamath   +3 more
openalex   +1 more source

Insect I‐Type Lysozymes Function as Antiviral Proteases by Forming Biomolecular Condensates

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Upon rice viral infection, the insect vector activates the Toll–MyD88–Dorsal signaling cascade, inducing i‐type lysozyme (Lyz‐I1) expression. Lyz‐I1 functions as an antiviral protease through its conserved catalytic dyad Glu/Asp (E/D), mediating cleavage of viral proteins at specific Lys (K) residues.
Yu Du, Yuqing Xiao, Manman Hu, Jinhua Yang, You Li, Taiyun Wei   +5 more
wiley   +1 more source

Pharmacokinetic Interactions between the Hepatitis C Virus Inhibitors Elbasvir and Grazoprevir and HIV Protease Inhibitors Ritonavir, Atazanavir, Lopinavir, and Darunavir in Healthy Volunteers. [PDF]

Antimicrob Agents Chemother, 2019
Feng HP, Caro L, Fandozzi C, Chu X, Guo Z, Talaty J, Panebianco D, Dunnington K, Du L, Hanley WD, Fraser IP, Mitselos A, Denef JF, De Lepeleire I, de Hoon JN, Vandermeulen C, Marshall WL, Jumes P, Huang X, Martinho M, Valesky R, Butterton JR, Iwamoto M, Yeh WW.   +23 more
europepmc   +1 more source

Blood‐based Alzheimer's disease biomarkers and cognitive trajectories in older people with HIV with undetectable viral loads

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Cognitive impairment among people with HIV (PWH) remains common, yet underlying mechanisms remain unclear. Alzheimer's disease (AD) is the leading cause of dementia, and blood‐based biomarkers offer a promising diagnostic alternative.
Akarin Hiransuthikul, Poosanu Thanapornsangsuth, Watayuth Luechaipanit, Thanaporn Haethaisong, Sasiwimol Ubolyam, Tanakorn Apornpong, Win Min Han, Stephen Kerr, Anchalee Avihingsanon, HIV‐NAT 006 and 207 study team   +9 more
wiley   +1 more source

Molecular Modeling of Anti HIV Drugs of Protease Inhibitor Group by CoMFA

, 2019
M B Kalhans, A. K. Singh, Nidhi Singh
openalex   +1 more source

HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells

Proceedings of the National Academy of Sciences of the United States of America, 2007
C. Coffinier, Sarah E Hudon, Emily A. Farber, Sandy Chang, C. Hrycyna, S. Young, L. Fong   +6 more
semanticscholar   +1 more source

Discovery of Oxyacanthine Dihydrochloride Monohydrate Polymorphs from Obfuscated Samples by Microcrystal Electron Diffraction

ChemMedChem, Volume 21, Issue 1, January 2026.
The practical application of microcrystal electron diffraction is demonstrated to identify two polymorphic crystal structures of oxyacanthine dihydrochloride monohydrate from obfuscated samples that had been mislabeled as "berbamine dihydrochloride".
Jieye Lin, Orel Paz, Johan Unge, Tamir Gonen   +3 more
wiley   +1 more source