Туберкулез и болезни лёгких, 2019 An HIV reservoir is a collection of HIV DNA in target cells in an HIV-infected person. HIV reservoir in patients with HIV infection prevents eradication of the pathogen and cure of the disease.
E. I. Veselova +3 more
doaj +3 more sources
A cohort-based study of host gene expression: tumor suppressor and innate immune/inflammatory pathways associated with the HIV reservoir size. [PDF]
PLoS Pathogens, 2023 The major barrier to an HIV cure is the HIV reservoir: latently-infected cells that persist despite effective antiretroviral therapy (ART). There have been few cohort-based studies evaluating host genomic or transcriptomic predictors of the HIV reservoir.
Ashok K Dwivedi +24 more
doaj +2 more sources
Inhibition of TIGIT on NK cells improves their cytotoxicity and HIV reservoir eradication potential [PDF]
mBioThe latent human immunodeficiency virus (HIV) reservoir presents the biggest obstacle to curing HIV chronic infection. Consequently, finding novel strategies to control the HIV reservoir is critical.
Yue Wang +11 more
doaj +2 more sources
CCL2: a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir [PDF]
mBio, 2022 HIV infects long-lived CD4 memory T cells, establishing a latent viral reservoir that necessitates lifelong antiretroviral therapy (ART). How this reservoir is formed so quickly after infection remains unclear.
Thomas A. Packard +16 more
doaj +2 more sources
Applications and limitations of the passenger hypothesis for HIV reservoir persistence and cure [PDF]
Journal of VirologyAntiretroviral therapy (ART) suppresses HIV replication in people living with HIV (PWH), but a persistent population of reservoir cells prevents cure. Reservoir cells are mostly anatomically dispersed, latently infected CD4+ T cells harboring one copy of
Joshua T. Schiffer +4 more
doaj +2 more sources
HIV Reservoir Characterization Symposium
Journal of Virus Eradication, 2017 The HIV Cure Research Center (HCRC) in Ghent organised the first HIV Reservoir Characterization Symposium, and brought together virologists, molecular biologists, immunologists and clinicians to discuss the most recent developments in HIV reservoir ...
Eva Malatinkova +3 more
doaj +2 more sources
Analysis of the effect of HDAC inhibitors on the formation of the HIV reservoir [PDF]
mBioThe HIV reservoir is more dynamic than previously thought with around 70% of the latent reservoir originating from viruses circulating within 1 year of the initiation of antiretroviral therapy (ART).
Lijun Ling +13 more
doaj +2 more sources
Impact of the initial administration of an antiretroviral drug with latency reversal properties on the HIV reservoir size [PDF]
Scientific ReportsThe elimination of the latent viral reservoir remains the main barrier in the quest for a cure for people with HIV (PWH). The administration of latency reversal agents (LRA) at antiretroviral treatment (ART) initiation could improve the effectiveness of ...
Erick De La Torre Tarazona +17 more
doaj +2 more sources
Neutralizing the HIV Reservoir [PDF]
Cell, 2014 Halper-Stromberg et al. use a humanized mouse model to demonstrate that broadly neutralizing antibodies, when administered with a combination of HIV latency activators, can reduce persistent HIV reservoirs, as measured by plasma virus rebound. Their results support the use of broadly neutralizing antibodies in HIV-reservoir-purging strategies.
Marsden, Matthew D, Zack, Jerome A
openaire +4 more sources
The HIV-1 latent reservoir is largely sensitive to circulating T cells
eLife, 2020 HIV-1-specific CD8+ T cells are an important component of HIV-1 curative strategies. Viral variants in the HIV-1 reservoir may limit the capacity of T cells to detect and clear virus-infected cells.
Joanna A Warren +17 more
doaj +1 more source