Results 91 to 100 of about 34,599 (210)
International Journal of Cancer, Volume 158, Issue 6, Page 1528-1540, 15 March 2026.What's new? Adult T‐cell leukemia/lymphoma (ATL) is a rare and aggressive malignancy caused by human T‐cell leukemia virus type 1 (HTLV‐1). The authors comprehensively analyzed the epidemiological and clinical features of ATL over a 30‐year period in French Guiana, a region with high HTLV‐1 endemicity and a multiethnic population.
Jill‐Léa Ramassamy +16 more
wiley +1 more source
Persistence of an intact HIV reservoir in phenotypically naive T cells
JCI Insight, 2020 Despite the efficacy of antiretroviral therapy (ART), HIV persists in a latent form and remains a hurdle to eradication. CD4+ T lymphocytes harbor the majority of the HIV reservoir, but the role of individual subsets remains unclear.
Emmanuele Venanzi Rullo +7 more
doaj +1 more source
Advanced Science, Volume 13, Issue 16, 18 March 2026.This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu +8 more
wiley +1 more source
Scientific ReportsHIV reservoir latently persists in people with HIV (PWH) despite long-term antiretroviral therapy (ART). Total HIV DNA quantification is commonly employed as a surrogate marker to assess the size of the viral reservoir.
Lucía Gutiérrez-García +5 more
doaj +1 more source
Nature Communications, 2019 How HIV reservoirs are shaped over time on antiviral therapy is poorly understood. Here, the authors analyze the dynamics of the HIV reservoir by longitudinal proviral sequencing revealing that HIV reservoir expression can contribute to its clearance and
Marilia Rita Pinzone +16 more
doaj +1 more source
Journal of Medical Virology, Volume 98, Issue 3, March 2026.ABSTRACT The current highly active antiretroviral therapy (HAART or ART) effectively suppresses de novo HIV‐1 infection but fails to eliminate HIV reservoir cells, which leads to rapid viral rebound upon ART cessation. Chimeric antigen receptor (CAR) T cells engineered to target HIV‐1 Env⁺ cells offer a promising strategy to eliminate or control these ...
Yaoxian Lou +9 more
wiley +1 more source
Immune Exhaustion in Chronic Infection and Cancer: Signaling Pathways and Therapeutic Interventions
MedComm, Volume 7, Issue 3, March 2026.Immune exhaustion is a well‐established hallmark of both cancer and chronic infection. This review proposes a novel “infection–exhaustion–tumor axis” framework, wherein chronic pathogens (e.g., oncogenic viruses) evade immune surveillance by hijacking inflammatory signaling to drive immune cell exhaustion, thereby creating immunosuppressive niches ...
Yali Song +10 more
wiley +1 more source
PLoS PathogensHuman Immunodeficiency Virus type 1 (HIV-1) is responsible for the global HIV/AIDS epidemic and the establishment of an integrated HIV-1 reservoir remains the primary obstacle to cure.
Ghazal Sadri +34 more
doaj +1 more source
HIV Reservoirs and Treatment Strategies toward Curing HIV Infection
International Journal of Molecular SciencesCombination antiretroviral therapy (cART) has significantly improved the prognosis of individuals living with human immunodeficiency virus (HIV). Acquired immunodeficiency syndrome has transformed from a fatal disease to a treatable chronic infection. Currently, effective and safe anti-HIV drugs are available.
Matsuda, Kouki, Maeda, Kenji
openaire +2 more sources
MedComm, Volume 7, Issue 3, March 2026.This review focuses on the clinical features, molecular mechanisms, treatment methods, and preventive measures of the VZV, with the aim of providing a theoretical basis for the development of new treatment and prevention methods for HZ. ABSTRACT Varicella zoster virus (VZV) is a ubiquitous human herpesvirus that establishes lifelong latency and causes ...
Lei Peng +8 more
wiley +1 more source