Results 71 to 80 of about 36,601 (210)
Heterogeneity of HIV-1 latent reservoirs
Chinese Medical Journal, 2020 Abstract Antiretroviral therapy (ART) can effectively inhibit human immunodeficiency virus-1 (HIV-1) replication, but is not curative due to the existence of a stable viral latent reservoir harboring replication-competent proviruses.
Jia-Cong Zhao +3 more
openaire +3 more sources
Small Methods, EarlyView.This comprehensive review delivers an engineering‐centric analysis of microfluidic molecular diagnostic chips, breaking them down into foundational modules from fluid manipulation to bio‐sensing. Beyond chip design, it evaluates sample‐to‐answer integration strategies and commercial readiness levels.
Donghoon Koo +7 more
wiley +1 more source
Nonthermal plasma approaches for combating implant‐associated infections: A compendious review
VIEW, EarlyView.Implant‐associated infections pose serious clinical challenges. Non‐thermal plasma (NTP) modifications overcome this bottleneck in distinct ways relative to traditional sterilization methods. Gas‐phase plasmas generate highly energetic species, UV radiation and reactive oxygen/nitrogen species (RONS), which alter the implant surface properties.
A. M. Trimukhe +8 more
wiley +1 more source
Naturally Occurring ZCCHC3 Variants Modulate Antiretroviral Activity in Cynomolgus Macaques
Microbiology and Immunology, EarlyView.ABSTRACT Many mammalian cells restrict viral replication by utilizing various host restriction factors. We recently demonstrated that CCHC‐type zinc‐finger‐containing protein 3 (ZCCHC3) suppresses human immunodeficiency virus type 1 (HIV‐1) replication through multiple mechanisms.
Jacob Fadipe +3 more
wiley +1 more source
Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase‐1
The FEBS Journal, EarlyView.Structural analysis of human tyrosylprotein sulfotransferase‐1 (hTPST1) bound to a CCR5 N‐terminal peptide reveals how hTPST1 recognizes the Tyr3 sulfation site. Structure‐guided models of additional CCR5 sulfation states and full‐length assemblies provide a framework for understanding CCR5 tyrosine sulfation, a post‐translational modification relevant
Shinnosuke Tanaka +10 more
wiley +1 more source
International Journal of Dermatology, EarlyView.Cross‐sectional study among 70 sexual health clinic attendees (70% MSM) in Bucharest combining multisite STI testing with knowledge, attitudes, and practices assessment. Key findings include 35.5% bacterial STI prevalence, essential extragenital testing, and cost barriers to screening uptake.
Andrei Tanasov, George‐Sorin Tiplica
wiley +1 more source
, 2019 Persistence of transcriptionally silent but replication-competent HIV reservoir in resting CD4+T cells constitutes the major barrier to viral eradication. Small latent reservoirs are associated to a better prognosis and predictive of less likelihood to undergo virological rebound during simplified therapy.
openaire +1 more source
A spatiotemporal analysis of Salmonella bacteraemia in Queensland, 2010–2019
Internal Medicine Journal, EarlyView.Abstract Background Salmonellosis contributes to a significant burden on global healthcare systems. The impact of this foodborne bacterium is more pronounced when the infection is invasive, leading to bacteraemia and sepsis. Studies on invasive salmonellosis are few, and there is an urgent need to understand the spatial distribution of bacteraemia and ...
Naveen Manchal +3 more
wiley +1 more source
Episodic memory rehabilitation for HIV‐associated neurocognitive disorders: A scoping review
Journal of Neuropsychology, EarlyView.Abstract Despite extensive research on HIV‐associated neurocognitive disorders (HAND), interest in cognitive rehabilitation has emerged only within the past 15 years. HAND are characterised by mild‐to‐moderate impairments in multiple cognitive domains: attention, episodic memory and executive functions.
Signe Andersen, Sylvane Faure
wiley +1 more source
Highlights from the HIV Cure and Reservoir Symposium, 11–12 September 2017, Ghent, Belgium
Journal of Virus Eradication, 2018 For the second time, the HIV Cure Research Center (HCRC) at Ghent University organised the HIV Cure and Reservoir Symposium, in Ghent, Belgium, where in this two-day conference, virologists, molecular biologists, immunologists and clinicians presented ...
Sam Kint +4 more
doaj +1 more source