Results 91 to 100 of about 35,308 (213)

Exploring potential associations between the human microbiota and reservoir of latent HIV

Retrovirology
Background The rapid establishment and persistence of latent HIV-1 reservoirs is one of the main obstacles towards an HIV cure. While antiretroviral therapy supresses viral replication, it does not eradicate the latent reservoir of HIV-1-infected cells ...
Nel Marín-Sánchez, Roger Paredes, Alessandra Borgognone   +2 more
doaj   +1 more source

First Reported Case of Fulminant Weil's Disease in South Khorasan, Eastern Iran: Diagnostic Challenges in a Non‐Endemic Region and Implications for Military Deployment

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Weil's disease should be considered even in non‐endemic regions when compatible clinical findings are accompanied by relevant exposure history. This case is epidemiologically notable as the first documented report from South Khorasan Province, highlighting the diagnostic challenges of leptospirosis in non‐endemic settings and the potential ...
Zohreh Azarkar, Anahita Arian, Motahareh Mahi‐Birjand, Parvin Askari   +3 more
wiley   +1 more source

Structural basis of ligand selectivity in FAD/NAD(P)H‐dependent dehydrogenases: insights from trypanothione reductase and type II NADH dehydrogenase

Protein Science, Volume 35, Issue 7, July 2026.
Abstract FAD/NAD(P)H‐dependent dehydrogenases form a structurally conserved family of redox enzymes that participate in essential metabolic processes across parasites and higher organisms. Among them, trypanothione reductase (TR) is a key component of the redox metabolism of Leishmania species and represents an attractive target for antileishmanial ...
Giulia Chiara Maria Perrone, Serena Spadone, Anna Lucia Francavilla, Sara Morselli, Sabino Todisco, Margherita Ortalli, Jairo Alfonso Mendoza‐Roldan, Valeria Scaglione, Maria Noemi Sgobba, Lorenzo Guerra, Federica Belluti, Stefania Varani, Domenico Otranto, Anna De Grassi, Mariateresa Volpicella, Ciro Leonardo Pierri   +15 more
wiley   +1 more source

Ruminants Epidemiology, Spatial Clustering and Multivariate Risk Modelling of Cutaneous Leishmaniasis in District Bajaur, Pakistan

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
This study investigated the epidemiology, risk factors and spatial distribution of cutaneous leishmaniasis in District Bajaur, Pakistan. Higher prevalence was observed among young males during summer, with lesions mainly on exposed body parts. Spatial analysis identified Khar, Loe Mamund and Salarzai as hotspots, highlighting the need for targeted ...
Murad Ali Khan, Jawad Ali, Zohaib Ali, Abdur Rehman, Muhammad Shoib, Sadaf Fayaz, Rifat Ullah Khan, Shabana Naz, Naseer Khan Momand, Antonella Perillo, Ibrahim A. Alhidary   +10 more
wiley   +1 more source

Duplex digital PCR assay on microfluidic chamber arrays for total HIV DNA reservoir quantification in persons with HIV

Scientific Reports
HIV reservoir latently persists in people with HIV (PWH) despite long-term antiretroviral therapy (ART). Total HIV DNA quantification is commonly employed as a surrogate marker to assess the size of the viral reservoir.
Lucía Gutiérrez-García, Andrés Esteban-Cantos, Javier Rodríguez-Centeno, Cristina Marcelo-Calvo, Jose R. Arribas, Berta Rodés   +5 more
doaj   +1 more source

Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion

Nature Communications, 2019
How HIV reservoirs are shaped over time on antiviral therapy is poorly understood. Here, the authors analyze the dynamics of the HIV reservoir by longitudinal proviral sequencing revealing that HIV reservoir expression can contribute to its clearance and
Marilia Rita Pinzone, D. Jake VanBelzen, Sam Weissman, Maria Paola Bertuccio, LaMont Cannon, Emmanuele Venanzi-Rullo, Stephen Migueles, R. Brad Jones, Talia Mota, Sarah B. Joseph, Kevin Groen, Alexander O. Pasternak, Wei-Ting Hwang, Brad Sherman, Anastasios Vourekas, Giuseppe Nunnari, Una O’Doherty   +16 more
doaj   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, Volume 16, Issue 6, Page 1132-1141, June 2026.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear‐induced Death During Hematogenous Dissemination

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang, Qianchun Wang, Keming Li, Guanshuo Hu, Ying Xin, Kai Tang, Bing Hu, Pengyu Du, Renwei Mao, Baohua Ji, Youhua Tan   +10 more
wiley   +1 more source

Development and validation of HIV SMRTcap for the characterization of HIV-1 reservoirs across tissues and subtypes.

PLoS Pathogens
Human Immunodeficiency Virus type 1 (HIV-1) is responsible for the global HIV/AIDS epidemic and the establishment of an integrated HIV-1 reservoir remains the primary obstacle to cure.
Ghazal Sadri, Steven T Nadakal, William Lauer, Justin Kos, Parmit K Singh, Erin Elliott, Catherine W Kaiser, Easton E Ford, Nadia Richardson, Kaitlyn M Shields, Elizabeth Hudson, Noemi L Linden, Ali Danesh, James Powell, Peter Warburton, Juan Soto, Matthew Emery, Gintaras Deikus, Guinevere Q Lee, Susanna L Lamers, Steven J Reynolds, Ronald Galiwango, Jessica L Prodger, Stephen Tomusange, Taddeo Kityamuweesi, Tina Han, R Brad Jones, Aaron A R Tobian, Alan N Engelman, Robert Sebra, Susan Morgello, Andrew D Redd, David Sachs, Eric Rouchka, Melissa L Smith   +34 more
doaj   +1 more source

New Insights Into the Role of Neutrophils in Lymphoma

Cancer Medicine, Volume 15, Issue 6, June 2026.
Tissue‐resident neutrophils challenge conventional paradigms by actively infiltrating normal lymphoid organs, predominantly localizing in interstitial compartments, a spatial distribution distinct from their classical vascular positioning. Neutrophils in lymphoid organs exhibit unique phenotypic and functional signatures, suggesting they play roles in ...
Ling Gu
wiley   +1 more source