Results 11 to 20 of about 34,599 (210)

Blood Center Testing Allows the Detection and Rapid Treatment of Acute and Recent HIV Infection

Viruses, 2022
Blood donations in South Africa are tested for HIV RNA using individual donation NAT (ID-NAT), allowing detection and rapid antiretroviral therapy (ART) of acute HIV infections.
Karin van den Berg, Marion Vermeulen, Sonia Bakkour, Mars Stone, Genevieve Jacobs, Cynthia Nyoni, Coreen Barker, Christopher McClure, Darryl Creel, Eduard Grebe, Nareg Roubinian, Ute Jentsch, Brian Custer, Michael P. Busch, Edward L. Murphy, on behalf of the Recipient Epidemiology and Donor Evaluation Study (REDS)-III South Africa International Program   +15 more
doaj   +1 more source

Tissue reservoirs of HIV [PDF]

Current Opinion in HIV and AIDS, 2016
Tissue reservoirs of HIV may promote the persistent immunopathology responsible for non-AIDS morbidity and data support multifocal reactivation from tissues as the source of viral rebound during antiretroviral therapy (ART) interruption. The heterogeneity of tissue reservoirs and incomplete knowledge about their composition are obstacles to an HIV cure.
Wong, Joseph K, Yukl, Steven A
openaire   +4 more sources

CD32+CD4+ T Cells Are Highly Enriched for HIV DNA and Can Support Transcriptional Latency

Cell Reports, 2020
Summary: The HIV latent reservoir forms the major hurdle to an HIV cure. The discovery of CD32 as marker of this reservoir has aroused much interest, but subsequent reports have challenged this finding. Here, we observe a positive correlation between the
Gilles Darcis, Neeltje A. Kootstra, Berend Hooibrink, Thijs van Montfort, Irma Maurer, Kevin Groen, Suzanne Jurriaans, Margreet Bakker, Carine van Lint, Ben Berkhout, Alexander O. Pasternak   +10 more
doaj   +1 more source

The reservoir of latent HIV

Frontiers in Cellular and Infection Microbiology, 2022
The persistence of latent reservoir of the human immunodeficiency virus (HIV) is currently the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV is unable to be recognized by the body’s immune system. Currently, the widely adopted antiretroviral therapy (ART) is also unble to eliminate it, thus hindering the ...
Jing Chen, Tong Zhou, Yuan Zhang, Shumin Luo, Huan Chen, Dexi Chen, Chuanyun Li, Weihua Li   +7 more
openaire   +3 more sources

Identification of CD98 as a Novel Biomarker for HIV-1 Permissiveness and Latent Infection

mBio, 2022
Human immunodeficiency virus type 1 (HIV-1) can integrate viral DNA into host cell chromosomes to establish a long-term stable latent reservoir, which is a major obstacle to cure HIV-1 infection. The characteristics of the HIV-1 latent reservoir have not
Wanying Zhang, Mo Zhou, Cancan Chen, Shiyu Wu, Lilin Wang, Baijin Xia, Jun Liu, Xiancai Ma, Ting Pan, Hui Zhang, Linghua Li, Bingfeng Liu   +11 more
doaj   +1 more source

Advances in Pediatric HIV-1 Cure Therapies and Reservoir Assays

Viruses, 2022
Significant advances in the field of HIV-1 therapeutics to achieve antiretroviral treatment (ART)-free remission and cure for persons living with HIV-1 are being made with the advent of broadly neutralizing antibodies and very early ART in perinatal ...
Priya Khetan, Yufeng Liu, Adit Dhummakupt, Deborah Persaud   +3 more
doaj   +1 more source

Dynamics of HIV DNA reservoir seeding in a cohort of superinfected Kenyan women.

PLoS Pathogens, 2020
A reservoir of HIV-infected cells that persists despite suppressive antiretroviral therapy (ART) is the source of viral rebound upon ART cessation and the major barrier to a cure.
Mark D Pankau, Daniel B Reeves, Elias Harkins, Keshet Ronen, Walter Jaoko, Kishor Mandaliya, Susan M Graham, R Scott McClelland, Frederick A Matsen Iv, Joshua T Schiffer, Julie Overbaugh, Dara A Lehman   +11 more
doaj   +1 more source

HIV in the Brain: Identifying Viral Reservoirs and Addressing the Challenges of an HIV Cure

Vaccines, 2021
Advances in antiretroviral therapy have prolonged the life of people living with HIV and diminished the level of virus in these individuals. Yet, HIV quickly rebounds after disruption and/or cessation of treatment due to significant cellular and ...
Michelle K. Ash, Lena Al-Harthi, Jeffrey R. Schneider   +2 more
doaj   +1 more source

Biomarker reveals HIV's hidden reservoir [PDF]

eLife, 2014
Determining the total amount of HIV DNA in people undergoing antiretroviral therapy could accelerate the development of novel therapies and potential cures for HIV infection.
Leslie R Cockerham, Steven G Deeks
openaire   +4 more sources

Engineering CAR T Cells to Target the HIV Reservoir

Frontiers in Cellular and Infection Microbiology, 2020
The HIV reservoir remains to be a difficult barrier to overcome in order to achieve a therapeutic cure for HIV. Several strategies have been developed to purge the reservoir, including the “kick and kill” approach, which is based on the notion that ...
Wenli Mu, Mayra A. Carrillo, Scott G. Kitchen   +2 more
doaj   +1 more source