Results 21 to 30 of about 34,599 (210)
Predicting Post-treatment HIV Remission: Does Size of the Viral Reservoir Matter?
Frontiers in Microbiology, 2021 Combination antiretroviral therapy (ART) suppresses human immunodeficiency virus (HIV) replication and improves immune function. However, due to the persistence of long-lived HIV reservoirs, therapy interruption almost inevitably leads to a fast viral ...
Alexander O. Pasternak +2 more
doaj +1 more source
Peering into the HIV reservoir [PDF]
Reviews in Medical Virology, 2018 SummaryThe main obstacle to HIV eradication is the establishment of a long‐term persistent HIV reservoir. Although several therapeutic approaches have been developed to reduce and eventually eliminate the HIV reservoir, only a few have achieved promising results.
Marcial García +3 more
openaire +3 more sources
HIV-1 Latent Reservoir: Size Matters [PDF]
Future Virology, 2016 More than 35 million people remain infected with HIV-1. Upon antiretroviral therapy cessation, HIV-1-positive individuals systematically fail to achieve sustained virological remission, revealing the presence of a reservoir. This reservoir takes into account anatomical sanctuaries where HIV-1 continues to replicate, and latently infected cells also ...
Hodel, F. +3 more
openaire +3 more sources
Retrovirology, 2007 Background The presence of HIV-1 preintegration reservoir was assessed in an in vitro experimental model of latent HIV-1 infection, and in patients treated or not with highly active antiretroviral therapy (HAART).
Baillat Vincent +7 more
doaj +1 more source
Journal of Virus Eradication, 2022 The HIV reservoir is a population of 1–10 million anatomically dispersed, latently infected memory CD4+ T cells in which HIV DNA is quiescently integrated into human chromosomal DNA.
Florencia A. Tettamanti Boshier +6 more
doaj +1 more source
HIV-1 Reservoirs During Suppressive Therapy [PDF]
Trends in Microbiology, 2016 The introduction of antiretroviral therapy (ART) 20 years ago has dramatically reduced morbidity and mortality associated with HIV-1. Initially there was hope that ART would be curative, but it quickly became clear that even though ART was able to restore CD4(+) T cell counts and suppress viral loads below levels of detection, discontinuation of ...
Kirston, Barton +2 more
openaire +2 more sources
Inducible HIV-1 Reservoir Quantification: Clinical Relevance, Applications and Advancements of TILDA
Frontiers in Microbiology, 2021 The presence of a stable HIV-1 reservoir persisting over time despite effective antiretroviral suppression therapy precludes a cure for HIV-1. Characterizing and quantifying this residual reservoir is considered an essential prerequisite to develop and ...
Cynthia Lungu +3 more
doaj +1 more source
Anti-HIV Antibody Responses and the HIV Reservoir Size during Antiretroviral Therapy. [PDF]
PLoS ONE, 2016 A major challenge to HIV eradication strategies is the lack of an accurate measurement of the total burden of replication-competent HIV (the "reservoir").
Sulggi A Lee +11 more
doaj +1 more source
Nanotechnology approaches to eradicating HIV reservoirs [PDF]
European Journal of Pharmaceutics and Biopharmaceutics, 2019 The advent of combination antiretroviral therapy (cART) has transformed HIV-1 infection into a controllable chronic disease, but these therapies are incapable of eradicating the virus to bring about an HIV cure. Multiple strategies have been proposed and investigated to eradicate latent viral reservoirs from various biological sanctuaries. However, due
Shijie Cao, Kim A. Woodrow
openaire +2 more sources
HIV Persistence in Adipose Tissue Reservoirs [PDF]
Current HIV/AIDS Reports, 2018 The purpose of this review is to examine the evidence describing adipose tissue as a reservoir for HIV-1 and how this often expansive anatomic compartment contributes to HIV persistence.Memory CD4 T cells and macrophages, the major host cells for HIV, accumulate in adipose tissue during HIV/SIV infection of humans and rhesus macaques.
Jacob, Couturier, Dorothy E, Lewis
openaire +2 more sources