Results 31 to 40 of about 34,599 (210)

New Frontiers in Measuring and Characterizing the HIV Reservoir

Frontiers in Microbiology, 2019
A cure for HIV infection remains elusive due to the persistence of replication-competent HIV proviral DNA during suppressive antiretroviral therapy (ART).
Shane D. Falcinelli, Shane D. Falcinelli, Cristina Ceriani, Cristina Ceriani, David M. Margolis, David M. Margolis, David M. Margolis, Nancie M. Archin, Nancie M. Archin   +8 more
doaj   +1 more source

Are HIV-1-Specific Antibody Levels Potentially Useful Laboratory Markers to Estimate HIV Reservoir Size? A Review

Frontiers in Immunology, 2021
Despite the benefits achieved by the widespread availability of modern antiretroviral therapy (ART), HIV RNA integration into the host cell genome is responsible for the creation of latent HIV reservoirs, and represents a significant impediment to ...
Silvere D. Zaongo, Feng Sun, Yaokai Chen
doaj   +1 more source

Measuring the HIV-1 reservoir [PDF]

Nature Reviews Microbiology, 2019
The description of a method to measure the HIV-1 reservoir that quantifies intact and defective proviruses.
openaire   +2 more sources

Machine learning approaches identify immunologic signatures of total and intact HIV DNA during long-term antiretroviral therapy

eLife
Understanding the interplay between the HIV reservoir and the host immune system may yield insights into HIV persistence during antiretroviral therapy (ART) and inform strategies for a cure.
Lesia Semenova, Yingfan Wang, Shane Falcinelli, Nancie Archin, Alicia D Cooper-Volkheimer, David M Margolis, Nilu Goonetilleke, David M Murdoch, Cynthia D Rudin, Edward P Browne   +9 more
doaj   +1 more source

Retinoids: novel potential therapeutics in the pursuit of HIV-1 cure

Frontiers in Virology, 2022
Human immunodeficiency virus (HIV) infection remains a global epidemic. While antiretroviral therapy (ART) suppresses viral replication, cessation of ART results in viral rebound necessitating lifelong treatment.
Andrew Purssell, Michaeline McGuinty, Michaeline McGuinty, Branka Vulesevic, Jonathan B. Angel, Jonathan B. Angel   +5 more
doaj   +1 more source

HIV reservoirs and latency models

Virology, 2011
The main impediment to a cure for HIV is the existence of long-lasting treatment resistant viral reservoirs. In this review, we discuss what is currently known about reservoirs, including their formation and maintenance, while focusing on latently infected CD4+ T cells.
Pace, Matthew J., Agosto, Luis, Graf, Erin H., O'Doherty, Una   +3 more
openaire   +2 more sources

Inducible HIV-1 Reservoir Reduction Assay (HIVRRA), a Fast and Sensitive Assay to Test Cytotoxicity and Potency of Cure Strategies to Reduce the Replication-Competent HIV-1 Reservoir in Ex Vivo PBMCs

Bio-Protocol
The HIV-1 reservoir, consisting of transcriptionally silent integrated HIV-1 proviruses, is a major barrier to a cure, as it persists during effective antiretroviral therapy (ART) and is the source of viral rebound upon treatment interruption.
Jade Jansen, Teunis Geijtenbeek, Neeltje Kootstra   +2 more
doaj   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Advances in the mechanism of regulatory T cells in human immunodeficiency virus infection

Guangxi Yike Daxue xuebao
Regulatory T cells (Tregs) are not only the target cells of human immunodeficiency virus (HIV) infection, but also critical mediators of immunosuppression and immune regulation.
YU Minrui, JIAO Yanmei, WANG Fusheng
doaj   +1 more source