Results 71 to 80 of about 34,599 (210)

The impact of COVID‐19 on public perceptions of wild meat in Central Africa

People and Nature, EarlyView.
Abstract Wild meat is a significant source of food and income generation in Central Africa. However, there is little knowledge of how the assumed link between COVID‐19 and wild meat consumption has been discussed by the media and received by the public. In this study, we conducted media content analysis of 264 articles published in 2019–2020 related to
Yuhan Li, Lude Kinzonzi, Paul Loundou, Divin Malekani, Krossy Mavakala, Christian Mikolo Yobo, Katharine Abernethy, Matilda Eve Dunn, Donald Midoko Iponga, Robert Mwinyihali, Joss Wright, Eleanor Jane Milner‐Gulland, Lauren Coad, Juliet H. Wright, Daniel W. S. Challender   +14 more
wiley   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

Prioritization of the Sustainable Development Goals: Developing and Testing a Novel Framework Under Varying Geographic Scales

Sustainable Development, EarlyView.
ABSTRACT This study develops and tests a novel prioritization framework for the Sustainable Development Goals (SDGs) under varying geographic scales (regional, sub‐regional, national), focusing on the Middle East and North Africa (MENA) region as a pilot case.
Lea Issa, Mutasem El Fadel
wiley   +1 more source

Hepatitis B Virus RNA Predicts Hepatocellular Carcinoma Despite Viral Suppression

Alimentary Pharmacology &Therapeutics, EarlyView.
Serum HBV RNA levels at viral suppression predict HCC development in nucleos(t)ide analogue‐treated patients with chronic hepatitis B, outperforming Hepatitis B core‐related antigen alone. ABSTRACT Background Despite achieving undetectable hepatitis B virus (HBV) DNA levels with nucleos(t)ide analogue (NA) therapy, patients with chronic hepatitis B ...
Takashi Kumada, Hidenori Toyoda, Satoshi Yasuda, Yuichi Koshiyama, Takanori Ito, Tomoyuki Akita, Junko Tanaka   +6 more
wiley   +1 more source

HIV e reservoir

, 2019
Persistence of transcriptionally silent but replication-competent HIV reservoir in resting CD4+T cells constitutes the major barrier to viral eradication. Small latent reservoirs are associated to a better prognosis and predictive of less likelihood to undergo virological rebound during simplified therapy.
openaire   +2 more sources

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

Immune non‐response despite effective antiretroviral therapy in people living with HIV: A review of potential mechanisms, biomarkers and therapeutic approaches

HIV Medicine, EarlyView.
Abstract Introduction A proportion of people living with HIV (PLWH) fail to restore their CD4 count or their CD4/CD8 ratio despite effective antiretroviral therapy (ART). PLWH with immune non‐response (INR) are at a higher risk of both AIDS and non‐AIDS events. The underlying mechanisms of INR remain unclear.
Charlotte Silvestre, Antoine Gross, Alain Makinson   +2 more
wiley   +1 more source

Highlights from the HIV Cure and Reservoir Symposium, 11–12 September 2017, Ghent, Belgium

Journal of Virus Eradication, 2018
For the second time, the HIV Cure Research Center (HCRC) at Ghent University organised the HIV Cure and Reservoir Symposium, in Ghent, Belgium, where in this two-day conference, virologists, molecular biologists, immunologists and clinicians presented ...
Sam Kint, Clarissa Van Hecke, Basiel Cole, Linos Vandekerckhove, Magdalena Sips   +4 more
doaj   +1 more source

The impact of accumulating immune adaptation in circulating strains of HIV‐1

HIV Medicine, EarlyView.
Abstract Background Mutations in human immunodeficiency virus type 1 (HIV‐1) enable the virus to evade recognition and killing by human leucocyte antigen (HLA)‐restricted T cells. These viral adaptations are specific to the HLA type of individuals and are therefore evident as HLA allele‐HIV sequence associations at the population level. Most studies of
Marwah Al‐kaabi, Alison Castley, Pooja Deshpande, Abha Chopra, David Nolan, Simon Mallal, Mina John, Silvana Gaudieri   +7 more
wiley   +1 more source