Results 161 to 170 of about 118,712 (218)

Geographical and temporal trends of HIV-1 subtypes and drug resistance in China: a nationwide study over two decades (2003-2024). [PDF]

J Gen Virol
Xie B, Wang Z, Song Q, Cui M, Deng Y, Zheng F, Krol E, Khouri R, De Clercq E, Mo J, Li G.   +10 more
europepmc   +1 more source

Resistance Analyses of Lenacapavir, Emtricitabine/Tenofovir Alafenamide and Emtricitabine/Tenofovir Disoproxil Fumarate in the PURPOSE 1 and 2 Studies. [PDF]

J Infect Dis
Cox S, Andreatta K, Hendricks MR, Li J, Kintu A, Brown LB, Carter CC, Callebaut C.   +7 more
europepmc   +1 more source

National representative survey of pretreatment HIV drug resistance in Colombia: analysis of antiretroviral resistance-associated mutations using next-generation sequencing. [PDF]

J Antimicrob Chemother
Martínez-Buitrago E, Zapata-Marín AF, Rubiano LC, Sañudo LM, Oñate JM, Lenis W, García-Góez JF, Álvarez JE, García-Morales C, Matías-Florentino M, Ávila-Ríos S.   +10 more
europepmc   +1 more source

Effectiveness and safety of two-drug regimens containing an integrase inhibitor and reverse transcriptase inhibitor in a cohort of virologically suppressed people with HIV: Data from the COMBINE-2 study. [PDF]

HIV Med
Mussini C, Henegar C, Assoumou L, de Wit S, Johnson M, Quiros-Roldan E, Kenyon C, Deschanvres C, Zucman D, Post F, Movahedi R, Comi L, Fox J, Liegeon G, Martin C, Edwards J, Tiecco G, Delforge M, Ragone L, Jones B, van Wyk J, Aboud M, Fletcher C, Pozniak A, Vannappagari V.   +24 more
europepmc   +1 more source

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HIV nucleoside reverse transcriptase inhibitors

European Journal of Medicinal Chemistry, 2022
More than 40 years into the pandemic, HIV remains a global burden and as of now, there is no cure in sight. Fortunately, highly active antiretroviral therapy (HAART) has been developed to manage and suppress HIV infection. Combinations of two to three drugs targeting key viral proteins, including compounds inhibiting HIV reverse transcriptase (RT ...
Franck, Amblard, Dharmeshkumar, Patel, Eleftherios, Michailidis, Steven J, Coats, Mahesh, Kasthuri, Nicolas, Biteau, Zahira, Tber, Maryam, Ehteshami, Raymond F, Schinazi   +8 more
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HIV-1 reverse transcriptase inhibitors

Applied Microbiology and Biotechnology, 2007
Reverse transcriptase (RT) is one of the three enzymes encoded by the human immunodeficiency virus type 1 (HIV-1), the etiological agent of AIDS. Together with protease inhibitors, drugs inhibiting the RNA- and DNA-dependant DNA polymerase activity of RT are the major components of highly active antiretroviral therapy (HAART), which has dramatically ...
El Safadi, Yazan, Vivet-Boudou, Valérie, Marquet, Roland   +2 more
openaire   +3 more sources

HIV reverse transcriptase structure-function relationships

Biochemistry, 1991
HIV reverse transcriptase (RT) is the target of the most widely used treatments for AIDS. Biochemical and mutagenesis studies performed on HIV-1 RT are reviewed in light of the enzyme's structure and functions. Features described include domain arrangement, dimerization, proteolytic processing, and specific recognition of the priming tRNA.
A, Jacobo-Molina, E, Arnold
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Fidelity of HIV-1 Reverse Transcriptase

Science, 1988
The human immunodeficiency virus type 1 (HIV-1) shows extensive genetic variation and undergoes rapid evolution. The fidelity of purified HIV-1 reverse transcriptase was measured during DNA polymerization in vitro by means of three different assays.
B D, Preston, B J, Poiesz, L A, Loeb
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Inhibitors of HIV‐1 Reverse Transcriptase

2008
Publisher Summary With the identification of human immunodeficiency virus (HIV)‐1 as the infectious agent leading to acquired immune deficiency syndrome (AIDS), the viral reverse transcriptase (RT) has been a primary focus for drug discovery and development. Currently, two classes of RT inhibitors are used clinically. Nucleoside reverse transcriptase
Tatiana, Ilina, Michael A, Parniak
openaire   +2 more sources