Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity
eLife, 2018 The highly polymorphic human leukocyte antigen (HLA) class I molecules present peptide antigens to CD8+ T cells, inducing immunity against infections and cancers.
Brogan Yarzabek +9 more
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Spondyloarthritis and the Human Leukocyte Antigen (HLA)-B*27 Connection [PDF]
Frontiers in Immunology, 2021 Heritability of Spondyloarthritis (SpA) is highlighted by several familial studies and a high association with the presence of human leukocyte antigen (HLA)-B*27. Though it has been over four decades since the association of HLA-B*27 with SpA was first determined, the pathophysiological roles played by specific HLA-B*27 allotypes are not fully ...
Chengappa G. Kavadichanda +4 more
openaire +3 more sources
A Molecular Basis for the Presentation of Phosphorylated Peptides by HLA-B Antigens. [PDF]
Mol Cell Proteomics, 2017 As aberrant protein phosphorylation is a hallmark of tumor cells, the display of tumor-specific phosphopeptides by Human Leukocyte Antigen (HLA) class I molecules can be exploited in the treatment of cancer by T-cell-based immunotherapy. Yet, the characterization and prediction of HLA-I phospholigands is challenging as the molecular determinants of the
Alpízar A +9 more
europepmc +4 more sources
Characteristics of graft-infiltrating lymphocytes after human heart transplantation: HLA mismatches and the cellular immune response within the transplanted heart [PDF]
, 1994 The influence of HLA mismatches between donor and recipient on the phenotypes, function, and specificity of T-lymphocyte cultures derived from endomyocardial biopsies was studied in 118 heart transplant recipients.
Baan, C.C. (Carla) +7 more
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High maternal-fetal HLA eplet compatibility is associated with severe manifestation of preeclampsia
Frontiers in Immunology, 2023 IntroductionPreeclampsia is responsible for more than 70 000 and 500 000 maternal and fetal deaths, respectively each year. Incomplete remodelling of the spiral arteries in placenta is the most accepted theory of preeclampsia pathogenesis.
Katarzyna Stefańska +19 more
doaj +1 more source
Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6 [PDF]
, 1989 Gene cloning and sequencing of the HLA-B locus split antigens B38 (B16.1) and B39 (B16.2) allowed localization of their subtypic as well as their public specificities HLA-Bw4 or -Bw6 to the c~-helical region of the c~ 1 domain flanked by the amino acid ...
Engler-Blum, G. +5 more
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Journal of Immunology Research, 2022 The human leukocyte antigen G (HLA-G) is an immune checkpoint molecule with a complex network of interactions with several inhibitory receptors. Although the effect of HLA-G on T cells and NK cells is well studied, the effect of HLA-G on B cells is still
Hana Rohn +8 more
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DR-bearing T lymphocytes in thoracic duct lymph [PDF]
, 1981 T cells having DR antigens were shown to be present in high numbers in the thoracic duct lymph of patients undergoing long-term drainage. As drainage progresses the proportion of T DR cells in the lymph increases to levels as high as 70% at 6 weeks ...
Abo +25 more
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PECULIARITIES OF HLA-PHENOTYPES IN PATIENTS WITH PYELONEPHRITIS [PDF]
Annals of Mechnikov's Institute, 2016 Introduction. Of great interest are the studies on the role of human leucocyte antigens (HLA) in pathogenesis of a disease. The kidneys is vulnerable to injury in the context of inflammatory responses, with the potential involvement of a number of ...
Haiseniuk F, Driyanska V, Kruglikov V
doaj +1 more source
Multiscreen serum analysis of highly sensitized renal dialysis patients for antibodies toward public and private class I HLA determinants: Implications for computer-predicted acceptable and unacceptable donor mismatches in kidney transplantation [PDF]
, 1990 A multiscreen serum analysis program has been developed that permits a determination of antibody specificity for the vast majority of highly sensitized patients awaiting transplantation.
Banner, BF +6 more
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