Results 201 to 210 of about 83,958 (230)

Structure of HLA-D/DR-BON Antigen

1989
The D-DR BON antigen was individualized among the DR blank specificities in 1986. Cells of this specificity were characterized by serologic unreactivity with all the allo-antisera of the 9th Histocompatibility Workshop and as being DQw1-positive. Studies in the French family BON by mixed lymphocyte culture allowed us to isolate a homozygous typing cell
J. Tkaczuk, M. Thomsen, M. Calot, A. Cambon-Thomsen, E. Ohayon   +4 more
openaire   +1 more source

Antigenic Products of the HLA-D Region

1981
A multitude of different cell-membrane alloantigens, complement factors, and components that may have important functions in the regulation of the immune response are controlled by the HLA genetic complex of chromosome 6 (W.F. Bodmer et al., 1978). In this chapter, the identification, structure, tissue distribution, and clinical importance of the HLA-D-
B. G. Solheim, D. Albrechtsen, E. Thorsby   +2 more
openaire   +1 more source

HLA‐D/DR Restriction of Macrophage‐dependent Antigen Activation of Immune T Lymphocytes: Cross‐reacting Allogeneic HLA‐D/DR May Partly Substitute for Self HLA‐D/DR

Scandinavian Journal of Immunology, 1980
Optimal proliferative response of T lymphocytes to purified protein derivative of tuberculin (PPD) III vitro requires that antigen be presented by autologous macrophages or allogeneic macrophages sharing HLA‐D/DR determinants with the T cell donor. In some cases, however, T cells may respond to a limited extent to PPD in association with macrophages ...
B O, Bergholtz, A B, Thoresen, E, Thorsby   +2 more
openaire   +2 more sources

HLA‐D restriction of antigen‐specific proliferative T cell responses

Tissue Antigens, 1983
The specificity of the inhibitory activity of anti HLA‐DR antisera on the proliferative response of human T cells to soluble antigens has been recently challenged. Furthermore, there are conflicting reports about the effect of antisera to the stimulatory antigen.
E. Thorsby, S. Ferrone, H. Nousiainen, H. Hirschberg   +3 more
openaire   +1 more source

HLA‐D‐Associated Ia‐Like’ Antigens on Human Macrophages

Scandinavian Journal of Immunology, 1977
Human macrophages procured by culture of adherent peripheral blood mononuclear cells were investigated for reactivity in complement‐dependent cytotoxicity tests with antisera having specificity for HLA‐D‐associated ‘Ia‐like’ B‐cell antigens. The antisera were found to be cytotoxic for 30%–70% of the macrophages from donors whose B cells were also ...
openaire   +2 more sources

Genes and Antigens of the HLA-D Region

1986
The role of the major histocompatibility complex (MHC) in rejections of transplanted organs was recognized early. The combined efforts of immunologists and immunogeneticists demonstrated that the human MHC represents one of the most genetically polymorphic loci hitherto identified.
P. A. Peterson, L. Rask
openaire   +1 more source

HLA–D and –DR antigens on human amniotic fluid cells

Tissue Antigens, 1983
Human amniotic fluid cells, known to express HLA–A, –B, and –C antigens, were tested for the presence of lymphocyte‐stimulating antigens (LD or HLA–D) using modifications of the mixed lymphocyte culture (MLC) and primed lymphocyte typing (PLT) tests. Peripheral blood lymphocytes were co‐cultured with various concentrations of allogeneic amniotic fluid ...
Elizabeth Valentine‐Thon, Gerlinde Kreeb, Hans Grosse‐Wilde, Eberhard Passarge   +3 more
openaire   +1 more source

HLA-D Related Antigens in Inflammatory Bowel Disease

1981
There is good evidence that genetic as well as environmental factors are important in the aetiology of inflammatory bowel disease (1). However, studies of HLA-A and -B specificities have not shown consistent differences between patients and controls. Nevertheless an investigation of the HLA-D related [DR] antigens in such patients would be of interest ...
W. R. Burnham, K. Gelsthorpe, M. J. S. Langman   +2 more
openaire   +1 more source

Generation of discriminatory PL against HLA-D antigens not detected by serology

Human Immunology, 1981
A family was studied in which the father and the mother were both homozygous for the HLA-DR antigens. All children responded to the parents in MLC, even though each had a copy of the parental DR antigen, implying that they recognized a difference. When the father or the mother was sensitized in PLT against any child, all siblings could restimulate ...
K S, Zier, B, Gansbacher
openaire   +2 more sources

Influence of HLA‐D/DR antigen disparity in CTL generation in vitro

Tissue Antigens, 1983
This report describes the influence of HLA‐D/‐DR antigen disparity upon the level of cytotoxicity in allogeneic in vitro cultures.Allogeneic cultures, between unrelated HLA‐D/‐DR full house donors, tested in CML gave three different levels of cytotoxicity, termed weak, intermediate and strong cytotoxicity.
H E, Johnsen, M, Madsen, J, Mossin, T, Kristensen   +3 more
openaire   +2 more sources