Results 61 to 70 of about 125,944 (285)

CD8+ T cells from patients with cirrhosis display a phenotype that may contribute to cirrhosis-associated immune dysfunctionResearch in context

EBioMedicine, 2019
: Background: Cirrhosis-associated immune dysfunction (CAID) contributes to high sepsis risk in patients with chronic liver disease. Various innate and; to a lesser extent; adaptive immune dysfunctions have been described as contributors to CAID leading
Fanny Lebossé, Cathrin Gudd, Enes Tunc, Arjuna Singanayagam, Rooshi Nathwani, Evangelos Triantafyllou, Oltin Pop, Naveenta Kumar, Sujit Mukherjee, Tie Zheng Hou, Alberto Quaglia, Fabien Zoulim, Julia Wendon, Ameet Dhar, Mark Thursz, Charalambos G. Antoniades, Wafa Khamri   +16 more
doaj   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes

Advanced Science, EarlyView.
This study identifies that pregnancy imprints a durable, pregnancy‐specific form of trained immune memory in uterine macrophages, marked by the emergence of LILRB3+/PIR‐B+ cells that expand across gestations, acquire a tolerogenic and metabolically rewired phenotype, and actively protect against inflammatory pregnancy loss in mice.
Jing Wang, Ning Lu, Xin‐Xiu Lin, Xu‐Hui Fang, Yi‐Hui Li, Qing‐Peng Luo, Yu‐Ting Peng, Gil Mor, Ai‐Hua Liao   +8 more
wiley   +1 more source

Bioinspired Morphology‐Decoupled Soft Gripper with Enhanced Bidirectional Grasping Capability

Advanced Science, EarlyView.
Inspired by biological predation, a novel gripper decouples cross‐modal grasping via dual morphological configurations. Synergistically integrating hybrid rigid and soft coupled fingers with a metamaterial palm, the system performs active compliant grasping for static objects and passive cage capture for dynamic targets.
Yedong Huang, Dazhong Yu, Baijin Mao, Fangming Li, Juntian Qu   +4 more
wiley   +1 more source

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source

Increased Numbers of CD4+ T‐Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1

Annals of Neurology, EarlyView.
Narcolepsy type 1 (NT1) is presumed to be an autoimmune disorder caused by hypothalamic loss of hypocretin (Hcrt; orexin). In postmortem NT1 brains, we observed an 11‐fold increase of CD4+ T‐cells in the Hcrt region compared with control hypothalami, without a corresponding rise in CD8+ T‐cells.
Ling Shan, Milo Fonville, Mabel Hoekstra, Rolf Fronczek, Joost Smolders, Dick F. Swaab   +5 more
wiley   +1 more source

HLA-DR regulation and the influence of GM-CSF on transcription, surface expression and shedding

International Journal of Medical Sciences, 2004
Low surface HLA-DR expression is a feature in sepsis. However, the mechanisms that regulate HLA-DR expression have not been elucidated. The current study investigates regulation of HLA-DR gene transcription, post transcriptional events and shedding of ...
doaj  

Nanostructured Lipid Carriers Overcome the Low Immunogenicity of M2e Peptide via Surface Click Chemistry Conjugation, Improving the Anti‐M2e Antibody Response

Advanced NanoBiomed Research, EarlyView.
1) Nanostructured lipid carriers efficiently vectorize low‐immunogenic M2e peptide. 2) M2e peptide conjugation via click chemistry preserves the peptide key epitopes. 3) Forty M2e peptides per nanoparticle are sufficient to induce robust immune responses.
Louis Bourlon, Carole Fournier, Antoine Hoang, Christine Charrat, Alban Lepetitcolin, Jessica Morlieras, Fabrice Navarro, Patrice N. Marche   +7 more
wiley   +1 more source

Antinuclear antibodies produced in HLA-DR transgenic humanized mice developed chronic graft-versus-host disease [PDF]

, 2021
Hiroshi Tsuzuki, Yasuko Nagatsuka, Mitsuhiro Iwata, Noboru Kitamura, Yosuke Nagasawa, Tarô Matsumoto, Ryoji Ito, Takeshi Takahashi, Mamoru Ito, Hideki Nakamura, Masami Takei   +10 more
openalex   +1 more source

Monocyte human leukocyte antigen-DR-mediated diabetic nephropathy progression is a promising therapeutic target

Frontiers in Endocrinology
ObjectiveIncreasing evidence has suggested that immune cells are known to play a pivotal role in the progression of diabetic nephropathy (DN). However, the specific causal role of monocyte surface markers, particularly human leukocyte antigen-DR (HLA-DR),
Yue Wang, Shaojie Fu, Sensen Su, Zhonggao Xu   +3 more
doaj   +1 more source