Results 1 to 10 of about 12,878,485 (338)
HLA-G and Recurrent Pregnancy Loss. [PDF]
Int J Mol Sci, 2023 Placentation is an immunological compromise where maternal immune system cells and trophoblastic cells interact to reach an equilibrium condition. Although the cross talk between the two systems is complex and not completely understood, Human Leukocyte ...
Barbaro G +5 more
europepmc +5 more sources
HLA-G/ILTs Targeted Solid Cancer Immunotherapy: Opportunities and Challenges
Frontiers in Immunology, 2021 Immune checkpoint inhibitors (ICIs) have become a promising immunotherapy for cancers. Human leukocyte antigen-G (HLA-G), a neoantigen, its biological functions and clinical relevance have been extensively investigated in malignancies, and early clinical
Aifen Lin +3 more
doaj +2 more sources
First immunotherapeutic CAR-T cells against the immune checkpoint protein HLA-G
Journal for ImmunoTherapy of Cancer, 2021 Background CAR-T cells immunotherapy is a breakthrough in the treatment of hematological malignancies such as acute lymphoblastic leukemia (ALL) and B-cell malignancies.
Olivier Adotevi +11 more
doaj +2 more sources
Signal Transduction and Targeted Therapy, 2021 Despite the successful use of the humanized monoclonal antibody trastuzumab (Herceptin) in the clinical treatment of human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer, the frequently occurring drug resistance remains to be ...
Weimiao Li, An-Gang Yang, Lin-Tao Jia
exaly +2 more sources
HLA-G/sHLA-G and HLA-G-Bearing Extracellular Vesicles in Cancers: Potential Role as Biomarkers
Frontiers in Immunology, 2021 As a non-classic major histocompatibility complex (MHC) class I molecule, human leukocyte antigen G (HLA-G) is expressed in fetal-maternal interface and immunoprivileged site only in healthy condition, and in pathological conditions such as cancer, it ...
Peilong Li +10 more
doaj +2 more sources
HLA-G: An Important Mediator of Maternal-Fetal Immune-Tolerance
Frontiers in Immunology, 2021 Maternal-fetal immune-tolerance occurs throughout the whole gestational trimester, thus a mother can accept a genetically distinct fetus without immunological aggressive behavior.
Baimei Zhuang, Jin Shang, Yuanqing Yao
exaly +2 more sources
Roles of HLA-G in the Maternal-Fetal Immune Microenvironment
Frontiers in Immunology, 2020 During pregnancy, the maternal uterus and fetus form a special microenvironment at the maternal-fetal interface to support fetal development. Extravillous trophoblasts (EVTs), differentiated from the fetus, invade into the decidua and interact with ...
Xiuxiu Xu, Yonggang Zhou, Haiming Wei
exaly +2 more sources
Role of HLA-G in Viral Infections
Frontiers in Immunology, 2022 The human leukocyte antigen (HLA)-G is a non-classical HLA class I molecule, which has distinct features to classical HLA-A, -B, -C antigens, such as a low polymorphism, different splice variants, highly restricted, tightly regulated expression and ...
Simon Jasinski-Bergner +4 more
doaj +2 more sources
HLA-G genetic diversity and evolutive aspects in worldwide populations
Scientific Reports, 2021 HLA-G is a promiscuous immune checkpoint molecule. The HLA-G gene presents substantial nucleotide variability in its regulatory regions. However, it encodes a limited number of proteins compared to classical HLA class I genes.
Erick C. Castelli +19 more
doaj +2 more sources
HLA-G Genotype/Expression/Disease Association Studies: Success, Hurdles, and Perspectives
Frontiers in Immunology, 2020 The non-classical HLA-G is a well-known immune-modulatory molecule. In physiological condition, HLA-G surface expression is restricted to the maternal–fetal interface and to immune-privileged adult tissues, whereas soluble forms of HLA-G are detectable ...
Giada Amodio, Silvia Gregori
doaj +2 more sources