The potential of HLA-G-bearing extracellular vesicles as a future element in HLA-G immune biology [PDF]
Frontiers in Immunology, 2016 The HLA-G molecule is a member of the non-classical HLA class I family. Its surface expression is physiologically restricted to the maternal-fetal interface and to immune privileged adult tissues.
Vera eRebmann
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HLA-G expression and role in advanced-stage classical Hodgkin lymphoma [PDF]
European Journal of Histochemistry, 2016 Non-classical human leucocyte antigen (HLA)-G class I molecules have an important role in tumor immune escape mechanisms. We investigated HLA-G expression in lymphonode biopsies taken from 8 controls and 20 patients with advanced-stage classical Hodgkin ...
G. Caocci +9 more
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HLA-G expression in peritumoral fundic gland mucous neck cells, but not in tumor lesions, related to poor survival in patients with gastric cancer [PDF]
Frontiers in ImmunologyIntroductionThe concept that human leukocyte antigen-G (HLA-G) expression is specifically in various malignant lesions but absent in adjacent normal tissues has been well documented, and HLA-G is acknowledged as a novel immune checkpoint.MethodsIn this ...
Xia Zhang +11 more
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The non-classical immune checkpoint HLA-G: a regulatory master switch governing tolerance, evasion, and translational frontiers [PDF]
Frontiers in OncologyHuman Leukocyte Antigen G (HLA-G), a non-classical MHC Class I molecule, plays a pivotal role in immune regulation, particularly in reproductive immunology.
Huan Liu +5 more
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Engineering HLA-G-targeted extracellular vesicles nanoplatform for enhanced cancer therapy through precise cancer drug delivery [PDF]
Nature CommunicationsExtracellular vesicles (EVs) hold great potential as a therapeutic delivery system for cancer treatment. Here, we develop an innovative targeted drug delivery platform, human leukocyte antigen-G-VHH antibody-modified EV (α-HLA-G-EV), to enhance ...
Ming-You Shie +12 more
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Frontiers in Immunology, 2022 Despite major improvements in diagnostics and therapy in early as well as in locally advanced breast cancer (LABC), metastatic relapse occurs in about 20% of patients, often explained by early micro-metastatic spread into bone marrow by disseminated ...
Vera Rebmann +10 more
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Frontiers in Immunology, 2022 IntroductionHLA-G plays a central role in immune tolerance at the maternal-fetal interface. The HLA-G gene is characterized by low allelic polymorphism and restricted tissue expression compared with classical HLA genes.
Lian Hu +3 more
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Human Leukocyte Antigens in Pregnancy and Preeclampsia
Frontiers in Genetics, 2022 Preeclampsia is a pregnancy-induced hypertensive disorder, the pathophysiology of which includes underlying maternal cardiovascular disease, deficient spiral artery remodeling during placenta development, and inflammatory immune responses at the maternal-
Omonigho Aisagbonhi, Gerald P. Morris
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HLA-G/ILTs Targeted Solid Cancer Immunotherapy: Opportunities and Challenges
Frontiers in Immunology, 2021 Immune checkpoint inhibitors (ICIs) have become a promising immunotherapy for cancers. Human leukocyte antigen-G (HLA-G), a neoantigen, its biological functions and clinical relevance have been extensively investigated in malignancies, and early clinical
Aifen Lin +3 more
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HLA-G: expression in human keratinocytes in vitro and in human skin in vivo [PDF]
, 1994 Classical, polymorphic major histocompatibility complex class I molecules are expressed on most nucleated cells.They present peptides at the cell surface and, thus, enable the immune system to scan peptides for their antigenicity.
Ulbrecht, M. +7 more
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