HLA-G*0105N null allele encodes functional HLA-G isoforms. [PDF]
Biology of reproduction, 2005 Expression of the nonclassical HLA class I antigen, HLA-G, is associated with immune tolerance in view of its role in maintaining the fetus in utero, allowing tumor escape, and favoring graft acceptance.
Carosella, Edgardo D +4 more
core +8 more sources
Haplotypes of the HLA-G 3' Untranslated Region Respond to Endogenous Factors of HLA-G+ and HLA-G- Cell Lines Differentially. [PDF]
PLoS ONE, 2017 The immune checkpoint HLA-G prevents maternal rejection of the fetus and contributes in cancer invasion and acceptance of allografts. The 5' and 3' regulatory regions of the HLA-G gene are polymorphic and balancing selection probably maintains this ...
Isabelle Poras +10 more
doaj +6 more sources
First immunotherapeutic CAR-T cells against the immune checkpoint protein HLA-G
Journal for ImmunoTherapy of Cancer, 2021 Background CAR-T cells immunotherapy is a breakthrough in the treatment of hematological malignancies such as acute lymphoblastic leukemia (ALL) and B-cell malignancies.
Olivier Adotevi +11 more
doaj +1 more source
HLA-G/sHLA-G and HLA-G-Bearing Extracellular Vesicles in Cancers: Potential Role as Biomarkers
Frontiers in Immunology, 2021 As a non-classic major histocompatibility complex (MHC) class I molecule, human leukocyte antigen G (HLA-G) is expressed in fetal-maternal interface and immunoprivileged site only in healthy condition, and in pathological conditions such as cancer, it ...
Peilong Li +10 more
doaj +1 more source
The Impact of HLA-G and HLA-E Polymorphisms on CMV Reinfection in Liver Transplant Recipients [PDF]
Iranian Journal of Immunology, 2022 Background: Cytomegalovirus (CMV) reinfection in transplant patients has been associated with graft loss and decreased patient survival. In this regard, the HLA-G molecule has the immunomodulatory characteristic and its soluble isoforms have important ...
Masumeh Darai +5 more
doaj +1 more source
Intratumor Heterogeneity of HLA-G Expression in Cancer Lesions
Frontiers in Immunology, 2020 Signaling pathway between human leukocyte antigen (HLA)-G and immune inhibitory receptors immunoglobulin-like transcript (ILT)-2/4 has been acknowledged as one of immune checkpoints, and as a potential target for cancer immunotherapy.
Xia Zhang +9 more
doaj +1 more source
MiRNA-mediated control of HLA-G expression and function. [PDF]
PLoS ONE, 2012 HLA-G is a non-classical HLA class-Ib molecule expressed mainly by the extravillous cytotrophoblasts (EVT) of the placenta. The expression of HLA-G on these fetal cells protects the EVT cells from immune rejection and is therefore important for a healthy
Irit Manaster +7 more
doaj +1 more source
A distant trophoblast-specific enhancer controls HLA-G expression at the maternal–fetal interface [PDF]
, 2016 HLA-G, a nonclassical HLA molecule uniquely expressed in the placenta, is a central component of fetus-induced immune tolerance during pregnancy. The tissue-specific expression of HLA-G, however, remains poorly understood.
Camahort, Raymond +12 more
core +1 more source
Association of HLA-A and Non-Classical HLA Class I Alleles.
PLoS ONE, 2016 The HLA-A locus is surrounded by HLA class Ib genes: HLA-E, HLA-H, HLA-G and HLA-F. HLA class Ib molecules are involved in immuno-modulation with a central role for HLA-G and HLA-E, an emerging role for HLA-F and a yet unknown function for HLA-H.
Federico Carlini +8 more
doaj +1 more source
HLA-G Expression in Lung Adenocarcinoma Tissues and Its Relationship with Prognosis
Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the expression of HLA-G and determine the prognostic value of HLA-G for lung adenocarcinoma. Methods The genomic alternation of HLA-G was analyzed using cBioPortal analytic tool.
ZHANG Wenlong +4 more
doaj +1 more source