HLA-G*0105N null allele encodes functional HLA-G isoforms. [PDF]
Biology of reproduction, 2005 Expression of the nonclassical HLA class I antigen, HLA-G, is associated with immune tolerance in view of its role in maintaining the fetus in utero, allowing tumor escape, and favoring graft acceptance.
Carosella, Edgardo D +4 more
core +8 more sources
Haplotypes of the HLA-G 3' Untranslated Region Respond to Endogenous Factors of HLA-G+ and HLA-G- Cell Lines Differentially. [PDF]
PLoS ONE, 2017 The immune checkpoint HLA-G prevents maternal rejection of the fetus and contributes in cancer invasion and acceptance of allografts. The 5' and 3' regulatory regions of the HLA-G gene are polymorphic and balancing selection probably maintains this ...
Isabelle Poras +10 more
doaj +6 more sources
The potential of HLA-G-bearing extracellular vesicles as a future element in HLA-G immune biology [PDF]
Frontiers in Immunology, 2016 The HLA-G molecule is a member of the non-classical HLA class I family. Its surface expression is physiologically restricted to the maternal-fetal interface and to immune privileged adult tissues.
Vera eRebmann
doaj +2 more sources
HLA-G expression and role in advanced-stage classical Hodgkin lymphoma [PDF]
European Journal of Histochemistry, 2016 Non-classical human leucocyte antigen (HLA)-G class I molecules have an important role in tumor immune escape mechanisms. We investigated HLA-G expression in lymphonode biopsies taken from 8 controls and 20 patients with advanced-stage classical Hodgkin ...
G. Caocci +9 more
doaj +3 more sources
HLA-G expression in peritumoral fundic gland mucous neck cells, but not in tumor lesions, related to poor survival in patients with gastric cancer [PDF]
Frontiers in ImmunologyIntroductionThe concept that human leukocyte antigen-G (HLA-G) expression is specifically in various malignant lesions but absent in adjacent normal tissues has been well documented, and HLA-G is acknowledged as a novel immune checkpoint.MethodsIn this ...
Xia Zhang +11 more
doaj +2 more sources
Harnessing the potential of HLA-G in cancer therapy: advances, challenges, and prospects. [PDF]
J Transl MedImmune checkpoint blockades have been prized in circumventing and ablating the impediments posed by immunosuppressive receptors, reaching an exciting juncture to be an innovator in anticancer therapy beyond traditional therapeutics.
Wang S +7 more
europepmc +2 more sources
Engineering HLA-G-targeted extracellular vesicles nanoplatform for enhanced cancer therapy through precise cancer drug delivery [PDF]
Nature CommunicationsExtracellular vesicles (EVs) hold great potential as a therapeutic delivery system for cancer treatment. Here, we develop an innovative targeted drug delivery platform, human leukocyte antigen-G-VHH antibody-modified EV (α-HLA-G-EV), to enhance ...
Ming-You Shie +12 more
doaj +2 more sources
HLA‐G: Function, polymorphisms and pathology [PDF]
International Journal of Immunogenetics, 2020 HLA‐G immune modulatory genes and molecules are presently being studied by a widespread number of research groups. In the present study, we do not aim to be exhaustive since the number of manuscripts published every year is overwhelming. Instead, our aim
A. Arnaiz-Villena +6 more
semanticscholar +4 more sources
OncoImmunology, 2017 Activated and in vitro expanded natural killer (NK) cells have substantial cytotoxicity against many tumor cells, but their in vivo efficacy to eliminate solid cancers is limited. Here, we used chimeric antigen receptors (CARs) to enhance the activity of
Sareetha Kailayangiri +2 more
exaly +2 more sources
Frontiers in Immunology, 2022 Despite major improvements in diagnostics and therapy in early as well as in locally advanced breast cancer (LABC), metastatic relapse occurs in about 20% of patients, often explained by early micro-metastatic spread into bone marrow by disseminated ...
Vera Rebmann +10 more
doaj +1 more source