Results 21 to 30 of about 12,878,485 (338)
The Molecular Mechanisms of HLA-G Regulatory Function on Immune Cells during Early Pregnancy
Biomolecules, 2023 Human leukocyte antigen-G (HLA-G) is a non-classical human major histocompatibility complex (MHC-I) molecule with the membrane-bound and soluble types.
Jia Mao +3 more
semanticscholar +1 more source
Frontiers in Immunology, 2022 IntroductionHLA-G plays a central role in immune tolerance at the maternal-fetal interface. The HLA-G gene is characterized by low allelic polymorphism and restricted tissue expression compared with classical HLA genes.
Lian Hu +3 more
doaj +1 more source
Human Leukocyte Antigens in Pregnancy and Preeclampsia
Frontiers in Genetics, 2022 Preeclampsia is a pregnancy-induced hypertensive disorder, the pathophysiology of which includes underlying maternal cardiovascular disease, deficient spiral artery remodeling during placenta development, and inflammatory immune responses at the maternal-
Omonigho Aisagbonhi, Gerald P. Morris
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HLA-G: Too Much or Too Little? Role in Cancer and Autoimmune Disease
Frontiers in Immunology, 2022 HLA-G is a non-classical HLA class I molecule with immunomodulatory properties. It was initially described at the maternal-fetal interface, and it was later found that this molecule was constitutively expressed on certain immuneprivileged tissues, such ...
J. Martín-Villa +10 more
semanticscholar +1 more source
Association of HLA-A and Non-Classical HLA Class I Alleles. [PDF]
PLoS ONE, 2016 The HLA-A locus is surrounded by HLA class Ib genes: HLA-E, HLA-H, HLA-G and HLA-F. HLA class Ib molecules are involved in immuno-modulation with a central role for HLA-G and HLA-E, an emerging role for HLA-F and a yet unknown function for HLA-H.
Federico Carlini +8 more
doaj +1 more source
HLA-G and Other Immune Checkpoint Molecules as Targets for Novel Combined Immunotherapies
International Journal of Molecular Sciences, 2022 HLA-G is an HLA-class Ib molecule that is involved in the establishment of tolerance at the maternal/fetal interface during pregnancy. The expression of HLA-G is highly restricted in adults, but the de novo expression of this molecule may be observed in ...
F. Morandi, I. Airoldi
semanticscholar +1 more source
HLA-G: expression in human keratinocytes in vitro and in human skin in vivo [PDF]
, 1994 Classical, polymorphic major histocompatibility complex class I molecules are expressed on most nucleated cells.They present peptides at the cell surface and, thus, enable the immune system to scan peptides for their antigenicity.
Ulbrecht, M. +7 more
core +5 more sources
Roles of HLA-G/KIR2DL4 in Breast Cancer Immune Microenvironment
Frontiers in Immunology, 2022 Human leukocyte antigen (HLA)-G is a nonclassical MHC Class I molecule, which was initially reported as a mediator of immune tolerance when expressed in extravillous trophoblast cells at the maternal-fetal interface.
Guoxu Zheng, L. Jia, Anderson Yang
semanticscholar +1 more source
Therapeutic Applications of Adeno-Associated Virus (AAV) Gene Transfer of HLA-G in the Eye
International Journal of Molecular Sciences, 2022 The purpose of this paper is to review human leukocyte antigen G (HLA-G) in the eye, its role in immune tolerance, and the potential therapeutic use of AAV gene transfer and expression of HLA-G in various ocular tissues. Several studies are reviewed that
B. Gilger, M. Hirsch
semanticscholar +1 more source
Prognostic Significance of Immune Checkpoints HLA-G/ILT-2/4 and PD-L1 in Colorectal Cancer
Frontiers in Immunology, 2021 Immune checkpoint inhibitors (ICIs) have become a promising area of research for cancer treatment. In addition to the well-known ICIs targeting PD-1/PD-L1, HLA-G/ILT-2/-4 is relatively new immune checkpoint that has been evaluated in early clinical ...
Qiong-Yuan Chen +8 more
semanticscholar +1 more source