HLA-G Expression Pattern: Reliable Assessment for Pregnancy Outcome Prediction [PDF]
Advanced Pharmaceutical Bulletin, 2013 Because mothers and fathers are more or less dissimilar at multiple HLA loci, mother considers her fetus as a semi-allograft. Mother's immune system may recognize paternal HLA as foreign antigen and may develop anti-paternal HLA antibodies and cytotoxic ...
Elnaz Mosaferi +5 more
doaj +1 more source
Immunological Compatibility Status of Placenta-Derived Stem Cells is Mediated by Scaffold 3D Structure [PDF]
, 2018 Placenta-derived amniotic epithelial cells (AECs), a great cell source for tissue engineering and stem cell therapy, are immunologically inert in their native state; however, immunological changes in these cells after culture and differentiation have ...
Azizian, Sara +8 more
core +2 more sources
HLA-G Genotype/Expression/Disease Association Studies: Success, Hurdles, and Perspectives
Frontiers in Immunology, 2020 The non-classical HLA-G is a well-known immune-modulatory molecule. In physiological condition, HLA-G surface expression is restricted to the maternal–fetal interface and to immune-privileged adult tissues, whereas soluble forms of HLA-G are detectable ...
Giada Amodio, Silvia Gregori
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Tolerogenic function of dimeric forms of HLA-G recombinant proteins: a comparative study in vivo. [PDF]
PLoS ONE, 2011 HLA-G is a natural tolerogenic molecule involved in the best example of tolerance to foreign tissues there is: the maternal-fetal tolerance. The further involvement of HLA-G in the tolerance of allogeneic transplants has also been demonstrated and some ...
Benoit Favier +7 more
doaj +1 more source
Linking Two Immuno-Suppressive Molecules: Indoleamine 2,3 Dioxygenase Can Modify HLA-G Cell-Surface Expression1 [PDF]
, 2005 Nonclassical human leukocyte antigen (HLA) class I molecule HLA-G and indoleamine 2,3 dioxygenase (INDO) in humans and mice, respectively, have been shown to play crucial immunosuppressive roles in fetal-maternal tolerance.
Alegre-Martinez, E. (Estibaliz) +8 more
core +1 more source
HLA-G and Recurrent Pregnancy Loss. [PDF]
Int J Mol Sci, 2023 Placentation is an immunological compromise where maternal immune system cells and trophoblastic cells interact to reach an equilibrium condition. Although the cross talk between the two systems is complex and not completely understood, Human Leukocyte Antigen G (HLA-G), expressed on trophoblastic cell surfaces, seems to be one of the main molecules ...
Barbaro G +5 more
europepmc +4 more sources
Expression of HLA-G in patients with B-cell chronic lymphocytic leukemia (B-CLL).
Folia Histochemica et Cytobiologica, 2009 The expression of HLA-G was reported in certain malignancies and its role in escaping from immunosurveillance in cancers was proposed since HLA-G is a nonconventional HLA class I molecule that protects fetus from immunorecognition during pregnancy ...
M Schmitt +4 more
doaj +1 more source
Functional Characterization of HLA-G+ Regulatory T Cells in HIV-1 Infection [PDF]
, 2013 Regulatory T cells represent a specialized subpopulation of T lymphocytes that may modulate spontaneous HIV-1 disease progression by suppressing immune activation or inhibiting antiviral T cell immune responses.
Li, Chun +8 more
core +4 more sources
Role of HLA-G in Viral Infections
Frontiers in Immunology, 2022 The human leukocyte antigen (HLA)-G is a non-classical HLA class I molecule, which has distinct features to classical HLA-A, -B, -C antigens, such as a low polymorphism, different splice variants, highly restricted, tightly regulated expression and ...
Simon Jasinski-Bergner +4 more
doaj +1 more source
Expression of HLA-G in inflammatory bowel disease provides a potential way to distinguish between ulcerative colitis and Crohn's disease. [PDF]
, 2004 In addition to being involved in nutrient uptake, the epithelial mucosa constitute the first line of defense against microbial pathogens. A direct consequence of this physiological function is a very complex network of immunological interactions that ...
Carosella, E. D. +8 more
core +4 more sources